Implication of ultraviolet B radiation exposure for non-melanoma skin cancer in Korea

Lee, Sang Geun; Yoon, Hong Seok; Bae, Hyun-joo; Ha, Jongsik; Pak, Haeyong; Shin, Yongseung; Son, Sang Wook

doi:10.1007/s13273-014-0011-1

Cited by 13 publications

(7 citation statements)

References 15 publications

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“…First, the NMSC cases were not divided into SCC and BCC because of the heterogeneity of C44 (other malignant neoplasm of skin), so the association between the use of HCTZ and BCC and SCC could not be examined. Second, UV exposure have been reported to increase the risk of skin cancer also in Korean, but as our study was register-based, we did not have access to individual-level data on history of UV exposure and skin phenotype [38]. However, this study was conducted in a homogeneous study population with similar race/ethnicity, and thus we presume that UV exposure and skin phenotypes can be regarded as not markedly different between HCTZ-users and non-HCTZ-users.…”

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confidence: 99%

Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea

Park

Lee

Jue

2020

Korean J Intern Med

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Background/Aims: Recent studies have shown a cumulative dose-dependent association between the use of hydrochlorothiazide (HCTZ) and skin cancer, including melanoma and non-melanoma skin cancer (NMSC) in Western Europe. However, whether this pattern is present in East Asia countries is unknown. The aim of this study was to examine the association between HCTZ use and the risk of skin cancer among a cohort of hypertensive patients in South Korea. Methods: This was a retrospective, population-based cohort study using the database from the Health Insurance Review and Assessment Service between January 1, 2007 and June 30, 2017 in South Korea. We identified patients diagnosed with melanoma and NMSC in the cohorts of essential hypertensive patients who were treated with HCTZ or antihypertensive agents other than HCTZ. Using Cox proportional hazards regression models, the hazard ratios (HR) for skin cancer associated with HCTZ users were calculated. Results: The risk of melanoma was significantly lower in HCTZ-users compared with non-HCTZ users (HR, 0.85; 95% confidence interval [CI], 0.75 to 0.97; p = 0.016), and the risk of NMSC was lower in the HCTZ users but no statistically significant association was seen (HR, 0.96; 95% CI, 0.91 to 1.02; p = 0.236). High cumulative doses (≥ 50,000 mg) of HCTZ were associated with decreased risk of both NMSC (HR, 0.20; 95% CI, 0.10 to 0.38; p < 0.001) and melanoma (HR, 0.18; 95% CI, 0.04 to 0.70; p = 0.001), respectively. Conclusions: High cumulative use of HCTZ may have a chemopreventive effect against the development of melanoma and NMSC with clear cumulative dose-response and duration-response relationships in South Korea.

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confidence: 99%

Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea

Park

Lee

Jue

2020

Korean J Intern Med

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“…Nine studies were retrospective cohort studies, 2 were case-control studies, and one was ecological (Table). Most studies were in East Asian populations, including 6 conducted in Korea, 4 in Taiwan, and 1 in Japan.…”

Section: Resultsmentioning

confidence: 99%

“…There were 4 studies that showed an association between UV exposure and KC . One Korean study by Lee et al found that the KC incidence rates in South Korea were higher with increasing annual UV-B index (based on geographic latitude) in people who were 60 years and older .…”

Section: Resultsmentioning

confidence: 99%

UV Exposure and the Risk of Keratinocyte Carcinoma in Skin of Color

et al. 2022

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eratinocyte carcinoma (KC), also known as nonmelanoma skin cancer, refers to basal cell carcinoma and squamous cell carcinoma. The incidence rates of KC are much lower among people with skin of color compared with people who identify as non-Hispanic White. 1 However, KCs in individuals with skin of color can be associated with worse outcomes owing to a higher risk for tumor invasion, metastasis, atypical clinical presentations, and delays in diagnosis compared with non-Hispanic White populations. 2 Ultraviolet exposure is the strongest modifiable risk factor associated with KC, but studies establishing this association have been primarily in non-Hispanic White populations. To date, and to our knowledge, there has been no comprehensive systematic review examining the association between UV exposure and KC among individuals with skin of color. Methods Personnel, Protocol, and RegistrationThe systematic review team included 5 reviewers (E.K., F.C.P.S.L., M.A., J.P., and A.S.A.) and 1 health sciences librarian (R.B.) from the University of Texas Libraries. The systematic review was registered on March 8, 2021, in the PROSPERO database (CRD42021234735). We used the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines. This research project was considered by The University of Texas at Austin Institutional Review Board as non-human participant research, and approval was not required.IMPORTANCE Ultraviolet radiation exposure is an important modifiable risk factor for keratinocyte carcinoma (KC) in fair-skinned non-Hispanic White populations; however, the evidence for this relationship in darker-skinned populations is less certain.OBJECTIVE To assess and synthesize the published data concerning the association between UV exposure and the risk of KC in individuals with skin of color.EVIDENCE REVIEW PubMed, Cochrane, and Web of Science databases were searched from database origin through January 2022. Studies deemed eligible included UV exposure as a risk factor for KC in individuals with skin of color, defined as any race other than non-Hispanic White, Fitzpatrick skin types IV to VI, or tanning ability of rarely or never burns. The UV index, irradiance, latitude, history of phototherapy, history of sunburn, or occupational exposure were used as measures of exposure. The Oxford Centre for Evidence-Based Medicine guidelines were used to assess evidence quality.FINDINGS A total of 72 716 articles appeared in the search. After duplicate removal, 29 393 database records were screened, 454 full-text articles were assessed, a forward and reverse citation search was performed, and 12 articles, with clinical data spanning the years 1990 to 2019, met inclusion criteria. More than 32 970 KCs in individuals with skin of color were included. Eight studies found no association between UV exposure and KC, while 4 studies showed a positive association. Study types included 1 ecological study, 9 cohort studies, and 2 case-control studies. The quality of the studies was rated from moderate to low...

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“…Species in the genus Deinococcus are characterized by their resistance to UVC, gamma radiation, and desiccation [1][2][3][4][5][6][7]. Ionizing radiation creates reactive oxygen species, which can damage DNA, in both prokaryotic and eukaryotic cells.…”

Section: Introductionmentioning

confidence: 99%

Deinococcus rubrus sp. nov., a Bacterium Isolated from Antarctic Coastal Sea Water

Srinivasan

Lim

et al. 2017

Journal of Microbiology and Biotechnology

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Two Gram-staining-negative, red-pinkish, coccus-shaped, non-motile, and aerobic bacterial strains, designated Ant21 and Ant22, were isolated from the Antarctic coastal sea water. Strains Ant21 and Ant22 showed UVC and gamma radiation resistance. Phylogenetic analyses based on 16 rRNA gene sequences determined that these strains belong to the genus . Through the analyses of the 16 rRNA gene sequences, strains Ant21 and Ant22 were found to have 97.7% and 97.8% similarity to DSM 12784 and 97.0% and 97.2% similarity to AA-1444, respectively. The sequence similarity with the type strains of other species was less than 96.9% for both strains. Strains Ant21 and Ant22 shared relatively high 16 rRNA gene sequence similarity (99.3%) and had a closely related DNA reassociation value of 84 ± 0.5%. Meanwhile, they showed a low level of DNA-DNA hybridization (<30%) with other closely related species of the genus . The two strains also showed typical chemotaxonomic features for the genus, in terms of the major polar lipid (phosphoglycolipid) and the major fatty acids (C, C6/7, iso-C , and iso-C). They grew at temperatures between 4°C and 30°C and at pH values of 6.0-8.0. Based on the physiological characteristics, the 16S rRNA gene sequence analysis results, and the low DNA-DNA reassociation level with , strains Ant21 (= KEMB 9004-167 =JCM 31436) and Ant22 (KEMB 9004-168 =JCM 31437) represent novel species belonging to the genus , for which the name is proposed.

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Implication of ultraviolet B radiation exposure for non-melanoma skin cancer in Korea

Cited by 13 publications

References 15 publications

Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea

Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea

UV Exposure and the Risk of Keratinocyte Carcinoma in Skin of Color

Deinococcus rubrus sp. nov., a Bacterium Isolated from Antarctic Coastal Sea Water

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