Implications of cancer-associated systemic inflammation for biomarker studies

Kowalewska, Magdalena; Nowak, Radosława; Chechlińska, Magdalena

doi:10.1016/j.bbcan.2010.06.002

Cited by 19 publications

(19 citation statements)

References 118 publications

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“…Met-DNA is believed to represent circulating tumor genomes, but not necessarily total DNA levels, as it can not only originate from tumor cells, but also from inflammatory cells, endothelial cells and fibroblasts in tumor tissues (19–21). Although the reason why total DNA levels in the serum is associated with prognosis remains unclear, it is possible that high total DNA levels in the serum may reflect specific tumor biology that is associated with tumor metastasis and tumor-induced inflammation.…”

Section: Discussionmentioning

confidence: 99%

Methylated DNA and high total DNA levels in the serum of patients with breast cancer following neoadjuvant chemotherapy are predictive of a poor prognosis

et al. 2014

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In a previous study, we established a one-step methylation-specific polymerase chain reaction (OS-MSP) assay for the detection of methylated DNA (met-DNA) and total DNA levels in serum. For the present study, this OS-MSP assay was used for patients with breast cancer treated with neoadjuvant chemotherapy (NAC) in order to investigate the prognostic significance of met-DNA and total DNA levels. Following treatment with NAC and prior to surgery, serum samples obtained from 120 patients with stage II/III breast cancer were subjected to the OS-MSP assay for analysis of the glutathione S-transferase pi 1, Ras association (RalGDS/AF-6) domain family member 1 and retinoic acid receptor β2 genes. The detection of methylation in a minimum of one of these genes indicated a positive outcome of the assay. The total DNA content of the serum was also determined. Of the 120 stage II/III patients, seven (6%) were positive for met-DNA in serum and showed a significantly worse overall survival (OS) time compared with patients negative for met-DNA (n=113) (5-year OS, 43 vs. 85%; P=0.002). The patients with high total DNA levels in serum (n=40) also showed a significantly worse OS compared with those with low total DNA levels (n=80) (65 vs. 91%; P<0.001). The presence of met-DNA and high total DNA levels in the serum were found to be significant prognostic factors that are independent of a pathological complete response by multivariate analysis. Following NAC, met-DNA and high total DNA levels in the serum detected with the OS-MSP assay constitute novel prognostic factors for patients with breast cancer; this may be clinically useful for the prognosis prediction for patients who do not achieve a pathological complete response following NAC.

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Section: Discussionmentioning

confidence: 99%

Methylated DNA and high total DNA levels in the serum of patients with breast cancer following neoadjuvant chemotherapy are predictive of a poor prognosis

et al. 2014

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“…It is now becoming clear that the stroma, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival, and migration [7,8,[49][50][51][52][53][54][55][56]. Fig.…”

Section: Inflammationmentioning

confidence: 99%

The Interplay Between Inflammation and Oxidative Stress in Carcinogenesis

Nowsheen

Aziz²,

Kryston³

et al. 2012

CMM

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Emerging data suggest that primary dysfunction in the tumor microenvironment is crucial for carcinogenesis. These recent findings make a compelling case for targeting the milieu for cancer chemoprevention as well as therapy. The stroma is an integral part of its physiology, and functionally, one cannot totally dissociate the tumor surrounding from the tumor cells. A thorough understanding of the tumor and stroma will aid us in developing new treatment targets. In this review, we shed light at the key aspects of the carcinogenic process and how oxidative stress and inflammation contribute to this process. We dissect the connection between metastasis and oxidative stress and focus on the key players in the tumor microenvironment that leads to inflammation, oxidative stress and DNA damage. Moreover, we consider the role of inflammation in disease, specifically cancer and metastasis. Finally, we discuss the potential applications in prognosis and cancer treatment.

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“…Inflammation is commonly generated as a host response to tumor development. Cancer biomarker studies should include a validation of markers against their expression in inflammatory conditions [158]. To select antigens applicable for cancer vaccination purposes from a spectrum of "true" cancer biomarkers, it is necessary to combine tools of proteomics in a complex approach that involves functional genomics, informatics and immunology.…”

Section: Proteomics For the Development Of Cancer Vaccinesmentioning

confidence: 99%