Abstract:Idiopathic preterm birth is associated with emergency cesarean delivery at term in previous pregnancies and infants with lower birth weight in previous and subsequent pregnancies.
“…Epidemiological studies have clearly demonstrated that a prior history of PTD is a major risk factor for its recurrence in a subsequent pregnancy 66,67 . It has been suggested that several candidate genes for polymorphisms associated with labor exist 68 .…”
Section: Genetic Factors and Preterm Deliverymentioning
“…Epidemiological studies have clearly demonstrated that a prior history of PTD is a major risk factor for its recurrence in a subsequent pregnancy 66,67 . It has been suggested that several candidate genes for polymorphisms associated with labor exist 68 .…”
Section: Genetic Factors and Preterm Deliverymentioning
“…Although many risk scoring systems have been devised, predicting a preterm birth is difficult. Prior preterm birth is a strong predictor of preterm delivery [2]. Although the pathogenesis of preterm labor is not well understood, progesterone withdrawal is theorized to play a part [3].…”
Objective To evaluate the role of 17 a hydroxyprogesterone caproate (17OHPC) in the prevention of preterm labor in high risk asymptomatic patients with a history of preterm delivery. Methods The study included 96 patients with a singleton pregnancy and having a prior preterm birth. They were divided in 2 groups, group I (treatment group) included 46 asymptomatic patients who were given 17OHPC injections starting from 16-20 weeks till 36 weeks and group II (control group) included 50 patients who did not receive any treatment. Results The incidence of preterm delivery was found to be 6.9 %. The median gestational age at delivery was 36 weeks in group I and 33 W5D in controls. 50 % cases in group I and 80 % of controls delivered prematurely in the group with a prior preterm birth between 20-28 weeks. Conclusion In patients who had a prior history of a preterm delivery the recurrence of a preterm birth was less in the treated group as compared to controls. The median gestational age at delivery was significantly higher in 17OHPC treated patients with history of earliest prior preterm delivery at 20-28 weeks.
“…Risk factors for preterm delivery were: a history of preterm delivery, smoking during pregnancy, and a history of abortion. Kristensen et al [9] found that a previous spontaneous preterm delivery gives a fivefold risk increase in preterm birth in the next pregnancy compared with women with first term delivery. Adams et al [10] found in a population-based cohort among almost 123,000 white and 56,000 black women that there is a high association between a preterm delivery in the first pregnancy and recurrence in the next one.…”
Section: Risk Factors For Recurrent Preterm Birthmentioning
confidence: 98%
“…Several studies have shown that there is an increased risk of preterm delivery when the first delivery was preterm [9][10][11]. An early prior spontaneous preterm birth is more predictive of recurrence and is highly associated with subsequent early spontaneous preterm birth [12].…”
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