This chapter reviews key concepts and terminologies needed for understanding the complexity of the vendor lock-in problem being investigated in this book. Firstly, we present aspects of cloud computing that contribute to vendor lock-in and briefly introduce existing results from cloud-related areas of computer science that contributes to understanding and tackling vendor lock-in. Secondly, we explore the literature on proprietary lock-in risks in cloud computing environments to identify its causes (i.e., restrictions), consequences, mitigations strategies, and related challenges faced by enterprise consumers migrating to cloudbased services. Then, we propose taxonomy of cloud lock-in perspectives based on reports of real experiences on migration to understand the overall cloud SaaS migration challenges. Finally, we narrow down to our perspective on cloud lock-in to three main perspectives which takes the use of sound techniques from IS research discipline and cloud-related literature into consideration, to improve the portability, security and interoperability of cloud (and on-premise) applications in hybrid environments. Collectively, the discussions presented herein, accordingly enables both academia and IT practitioners in the cloud computing community to get an overarching view of the process of combating application and data lock-in challenges, and security risks in the cloud.