Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland

Nisa, Lluís; Salmina, Cinzia; Dettmer, Matthias S.; Arnold, A.; Aebersold, Daniel M.; Borner, Urs; Giger, Roland

doi:10.1002/lary.25342

Cited by 23 publications

(31 citation statements)

References 26 publications

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“…Previous authors had reported the IPN metastasis rate ranged from 15 to 38%, and the IPN metastasis was significantly related to TNM stage and disease grade [8–11, 13–18], the finding was consistent with ours.…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, total parotidectomy was suggested for all parotid cancer patients by previous authors [15]. The high 10-year RFS rate in current study came into our attention, it was better than previous researches [8, 11], the favorable outcome might be partially explained by our routine total parotidectomy. Another potential explanation was that high grade disease only accounted for less than 15% in our sample, and previous authors had described the disease grade was an important prognostic factor in parotid cancers [17].…”

Section: Discussionmentioning

confidence: 51%

“…Klussmann et al [8] presented there was additional risk associated with the IPN involvement for tumor recurrence. Nisa et al [11] described patients with IPN metastasis had poorer disease control. However, the three studies were limited to small sample size, and also a considerable number of patients had not undergone total parotidectomy, there might be undiagnosed IPNs.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the exceptional growth process, there are intraparotid nodes (IPNs) in the parotid gland [7], its prognostic value remains unclear [8–11]. The IPNs are classified into superficial and deep lobe nodes [12], therefore the IPNs are significantly affected by different surgical procedures, compared to total parotidectomy, lateral or superficial parotidectomy has a lower probability to find all relevant IPNs, but in the above-mentioned researches [8–11], a certain number of procedures of lateral or superficial parotidectomy are included, therefore the exact IPN metastasis rate as well as its survival impact in patients with MEC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

2019

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s Background Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. But the role of intraparotid nodes (IPNs) remains unclear, therefore, the study aimed to analyze the significance of IPNs in predicting recurrence in parotid MEC. Methods One hundred and ninety patients were included for analysis finally. Data regarding demography, pathological characteristics, IPN metastasis, TNM stage, follow up was collected and evaluated. The recurrence-free survival (RFS) was the main study endpoint. Results A total of 47 (24.7%) patients had IPN metastasis, and the IPN metastasis was significantly related to tumor stage, pathologic N stage, lymph-vascular invasion, perineural invasion, and disease grade. Recurrence occurred in 34 (17.9%) patients. For patients without IPN metastasis, the 10-year RFS rate was 88%, for patients with IPN metastasis, the 10-year RFS rate was 54%, the difference was significant ( p < 0.001). Further Cox model analysis confirmed the independence of IPN metastasis in predicting the prognosis. Conclusion The IPN metastasis is relatively common in parotid MEC, it is significantly related to tumor stage and disease grade, IPN metastasis means worse recurrence-free survival.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

2019

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“…We first describe that IPN metastasis predicts worse RFS and DSS. There were similar findings in adults (29)(30)(31)(32). Lim et al (29) might have been the first to identify patients with cN0 neck disease, but their patients with IPN metastasis were more likely to develop locoregional recurrence than their patients who did not have IPN metastasis.…”

Section: Discussionmentioning

confidence: 52%

Significance of Pretreatment Neutrophil-to-Lymphocyte Ratio in Mucoepidermoid Carcinoma of Pediatrics: A Multicenter Study

Gao

Sun

2020

Front. Pediatr.

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Background: Our goal was to analyze the value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the prognosis of pediatrics with parotid mucoepidermoid carcinoma (MEC).Methods: Patients (≤18 years old) undergoing surgical treatment for primary parotid MEC were enrolled from multiple clinical centers retrospectively. The χ 2 -test was used to analyze the associations between clinicopathological variables and the NLR. The main study endpoints were recurrence-free survival (RFS) and disease-specific survival (DSS). The prognostic value of NLR was assessed by Kaplan-Meier method and Cox model analysis.Results: There were 88 patients included in total, with mean NLR of 2.32 (range, 1.8-6.0). Histologic tumor grade and tumor stage were associated with the NLR significantly. The 10-year RFS rates were 98 and 81% for patients with an NLR < 2.32 and patients with an NLR ≥ 2.32, respectively, the difference was significant (p = 0.010). The 10-year DSS rate was 97 and 81% for patients with an NLR < 2.32 and patients with an NLR ≥ 2.32, respectively; the difference was not significant (p = 0.072). The independence of NLR in predicting the RFS was further confirmed in Cox model analysis. Conclusion:The NLR significantly affects the prognosis in pediatrics with primary parotid MEC.

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Competing‐risks nomograms for predicting cause‐specific mortality in parotid‐gland carcinoma: A population‐based analysis

Xue

Zhao

et al. 2021

Cancer Medicine

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Introduction Parotid‐gland carcinoma (PGC) is a relatively rare tumor that comprises a group of heterogeneous histologic subtypes. We used the Surveillance, Epidemiology, and End Results (SEER) program database to apply a competing‐risks analysis to PGC patients, and then established and validated predictive nomograms for PGC. Methods Specific screening criteria were applied to identify PGC patients and extract their clinical and other characteristics from the SEER database. We used the cumulative incidence function to estimate the cumulative incidence rates of PGC‐specific death (GCD) and other cause‐specific death (OCD), and tested for differences between groups using Gray's test. We then identified independent prognostic factors by applying the Fine–Gray proportional subdistribution hazard approach, and constructed predictive nomograms based on the results. Calibration curves and the concordance index (C‐index) were employed to validate the nomograms. Results We finally identified 4,075 eligible PGC patients who had been added to the SEER database from 2004 to 2015. Their 1‐, 3‐, and 5‐year cumulative incidence rates of GCD were 10.1%, 21.6%, and 25.7%, respectively, while those of OCD were 2.9%, 6.6%, and 9.0%. Age, race, World Health Organization histologic risk classification, differentiation grade, American Joint Committee on Cancer (AJCC) T stage, AJCC N stage, AJCC M stage, and RS (radiotherapy and surgery status) were independent predictors of GCD, while those of OCD were age, sex, marital status, AJCC T stage, AJCC M stage, and RS. These factors were integrated for constructing predictive nomograms. The results for calibration curves and the C‐index suggested that the nomograms were well calibrated and had good discrimination ability. Conclusion We have used the SEER database to establish—to the best of our knowledge—the first competing‐risks nomograms for predicting the 1‐, 3‐, and 5‐year cause‐specific mortality in PGC. The nomograms showed relatively good performance and can be used in clinical practice to assist clinicians in individualized treatment decision‐making.

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Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland

Abstract: 4.

Cited by 23 publications

References 26 publications

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

Significance of Pretreatment Neutrophil-to-Lymphocyte Ratio in Mucoepidermoid Carcinoma of Pediatrics: A Multicenter Study

Competing‐risks nomograms for predicting cause‐specific mortality in parotid‐gland carcinoma: A population‐based analysis

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