Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

Abstract

s Background Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. But the role of intraparotid nodes (IPNs) remains unclear, therefore, the study aimed to analyze the significance of IPNs in predicting recurrence in parotid MEC. Methods One hundred and ninety patients were included for analysis finally. Data regarding demography, pathological characteristics, IPN metastasis, TNM stage, follow up was collected and evaluated. The recurrence-free survival (RFS) was the main study endpoint. Results A total of 47 (24.7%) patients had IPN metastasis, and the IPN metastasis was significantly related to tumor stage, pathologic N stage, lymph-vascular invasion, perineural invasion, and disease grade. Recurrence occurred in 34 (17.9%) patients. For patients without IPN metastasis, the 10-year RFS rate was 88%, for patients with IPN metastasis, the 10-year RFS rate was 54%, the difference was significant ( p < 0.001). Further Cox model analysis confirmed the independence of IPN metastasis in predicting the prognosis. Conclusion The IPN metastasis is relatively common in parotid MEC, it is significantly related to tumor stage and disease grade, IPN metastasis means worse recurrence-free survival.

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

“…The prognostic factors for parotid cancer have been widely analysed. Accepted survival predictors include high tumour stage, neck lymph node metastasis, perineural invasion, lymphovascular invasion, pathological tumour grade, neutrophil-to-lymphocyte ratio, resection margin, and intraparotid node metastasis [1, 3, 22–24]. Niu et al [23] retrospectively enrolled 35 patients with sarcomatoid carcinoma in the parotid gland, concluding that perineural invasion was the most important predictive factor.…”

“…From January 2005 to December 2016, medical records of patients with surgically treated parotid SCC were reviewed. Enrolled patients had to meet the following criteria: no previous history of SCC of the head and neck; pathological sections were re-reviewed to exclude the possibility of high grade mucoepidermoid carcinoma with the help of mucin stains [3–9]; and patients had undergone a PET-CT examination to exclude the possibility of metastatic disease. Data regarding age, sex, TNM stage based on the AJCC 7th system, pathological reports, and follow-up were extracted by JF-W and analysed by QG-F, JF-W and FL.…”

“…Parotid cancers account for 70% of all salivary gland malignancies, and there are 24 different types of malignancies [1–3], of which squamous cell carcinoma (SCC) is one of the least common histologic subtypes. SCC usually conveys a poor 5-year survival rate of less than 50% with an incidence varying from 0.1 to 10% in salivary malignancies [4–10].…”

Predictors of distant metastasis in parotid acinic cell carcinoma

“…However, whether IPN metastasis increases the risk of DM remained unknown; we are the first to find that IPN metastasis carries a risk of nearly 2-fold for decreasing survival with DMC. The underlying mechanism might be as follows: first, the N parameter in the TNM classification refers to regional and cervical lymph nodes, and while IPNs appear to play a sentinel role in predicting neck disease, they are not included in any of the neck lymph node groups; second, IPNs include superficial and deep parotid nodes, and unresected positive IPNs might remain after partial or superficial parotidectomy [18].…”

“…Data regarding age, sex, TNM stage, pathologic characteristics, surgical treatment, and follow-up examinations were collected. Intraparotid nodes (IPNs) are nodes located within the parotid tissue [18]. Postoperative radiotherapy is usually advised in our cancer centre when there are high-risk factors, including a high tumour stage, neck node metastasis, high-grade transformation, perineural invasion, lymphovascular invasion and IPN metastasis.…”