Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury

Sakamoto, Mineshi; Murata, Katsuyuki; Domingo, José L.; Yamamoto, Megumi; Oliveira, Rodrigo Santos de; Kawakami, Shoichi; Nakamura, Masaaki

doi:10.1016/j.envres.2016.04.023

Cited by 21 publications

(4 citation statements)

References 33 publications

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“…The median and geometric mean Hg level in the 17,997 samples were both 3.83 µg l −1 (3.65 ng g −1 ). Compared with other studies, these Hg levels are comparable with the blood Hg levels in pregnant Japanese women in 2006–2007 (median, 3.79 ng g −1 ; n = 54) [23] and another group of Japanese pregnant women (geometric mean, 5.18 ng g −1 ; n = 115, survey years not specified in the reference) [24]. The blood Hg levels in our study were also similar to those in pregnant Taiwanese women in 2010–2011 (median, 2.24 µg l −1 ; n = 145) [25].…”

Section: Discussionsupporting

confidence: 72%

Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS)

Nakayama

Iwai-Shimada

Oguri

et al. 2019

J Expo Sci Environ Epidemiol

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The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51–0.78) µg dl−1, 3.83 (2.70–5.43) µg l−1, 0.70 (0.52–0.95) µg l−1, 16.1 (13.2–19.6) µg l−1 and 178 (165–192) µg l−1, respectively. Hg and Se correlated positively with each other (Spearman’s ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5–10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.

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Section: Discussionsupporting

confidence: 72%

Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS)

Nakayama

Iwai-Shimada

Oguri

et al. 2019

J Expo Sci Environ Epidemiol

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“…A comparison of each heavy metal concentration with previous reports is described. Mercury concentrations were comparable to those in the blood of pregnant women in Japan in 2006–2007 and Taiwan in 2010–11 10 , 11 . The ratio is almost ten times higher than that of pregnant women in the US 12 , which may be attributed to a high seafood intake.…”

Section: Discussionmentioning

confidence: 66%

Association between maternal heavy metal exposure and Kawasaki Disease, the Japan Environment and Children’s Study (JECS)

Yanai,

Yoshida,

Takeuchi

et al. 2024

Sci Rep

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Kawasaki disease (KD) is an acute systemic vasculitis primarily affecting young children, with an unclear etiology. We investigated the link between maternal heavy metal exposure and KD incidence in children using the Japan Environment and Children’s Study, a large-scale nationwide prospective cohort with approximately 100,000 mother–child pairs. Maternal blood samples collected during the second/third trimester were analyzed for heavy metals [mercury (Hg), cadmium (Cd), lead (Pb), selenium (Se), manganese (Mn)], divided into four quartiles based on concentration levels. KD incidence within the first year of life was tracked via questionnaire. Among 85,378 mother–child pairs, 316 children (0.37%) under one year were diagnosed with KD. Compared with the lowest concentration group (Q1), the highest (Q4) showed odds ratios (95% confidence interval) for Hg, 1.29 (0.82–2.03); Cd, 0.99 (0.63–1.58); Pb, 0.84 (0.52–1.34); Se, 1.17 (0.70–1.94); Mn, 0.70 (0.44–1.11), indicating no concentration-dependent increase. Sensitivity analyses with logarithmic transformation and extended outcomes up to age 3 yielded similar results. No significant association was found between maternal heavy metal levels and KD incidence, suggesting that heavy metal exposure does not increase KD risk.

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“…There is limited human-based research on the effects of gestational or in-utero exposure on neurodegeneration to understand what pregnancy trimester could expose such disorder and the degree of impact on the fetus. Radioactive studies demonstrated that high levels of mercury and lead in umbilical cord blood due to prenatal exposures impair visual processing [144][145][146].…”

Section: In Utero Conditionsmentioning

confidence: 99%

Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

Ayeni

Aldossary

Ayejoto

et al. 2022

IJERPH

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Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions. The implications of environmental and climatic changes emerged recently as influence factors on numerous diseases. However, the complex interaction of neurotransmitters and neuronal hormones and their depletion under environmental and climatic influences on NDDs are not well established in the literature. In this review, we aim to explore the connection between the environmental and climatic factors to NDDs and to highlight the available and potential therapeutic interventions that could use to improve the quality of life and reduce susceptibility to NDDs.

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Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury

Cited by 21 publications

References 33 publications

Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS)

Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS)

Association between maternal heavy metal exposure and Kawasaki Disease, the Japan Environment and Children’s Study (JECS)

Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

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