Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever

Abstract

In a study comparing the virus load and immune reaction between patients with primary and secondary dengue-2 (DEN-2) infections in a hospital-based analysis, we found that 40.7% (55/135) of the 135 patients had secondary DEN-2 infection following a DEN-2 outbreak in southern Taiwan. Most of the secondary infections had subclinical primary dengue infections (78.2%; 43/55). Patients with secondary DEN-2 infections had lower platelet counts, and blood interferon-a and virus load, but significantly higher interleukin-10 (P = 0.030) and anti-DEN-1 neutralization titers (P = 0.013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load.

Determination of Viremia and Concentration of Circulating Nonstructural Protein 1 in Patients Infected with Dengue Virus in Mexico

“…14,29 Our results, consistent with previous results, indicate that viremia levels decay fast after fever onset 13,14 and that primary infections have higher viremias than secondary infections. 18,29 The reasons for these discrepant results are unknown, but indicate that viremia levels seem to be the results of a complex interplay between viral and host factors. [4][5][6][7][8]15 The observation that infections Figure 5.…”

Diagnosis of dengue: an update

“…This observation could be due to the interference of crossreactive Review antibodies with virus isolation or a faster rate of viral clearance in patients with secondary DENV infection [39]. Either explanation, however, suggests that the prevalence of primary or secondary DENV infection may influence the overall virus isolation [40,45].…”

Analysis of TLR4 (Asp299Gly and Thr399Ile) gene polymorphisms and mRNA level in patients with dengue infection: A case-control study

“…Patients coming to emergency department and general hospital of SGPGIMS were enrolled in the study. Patients were diagnosed to have dengue infection as per WHO guidelines (Pinheiro and Corber, 1997;WHO, 1997;Yeh et al, 2006). Written information consent was taken through a questionnaire from the patient or from the patient parent (in the case of minors) regarding the clinical information and their residing areas.…”