Implications of the gut microbiota in vulnerability to the social avoidance effects of chronic social defeat in male mice

Szyszkowicz, Joanna Kasia; Wong, Alex; Anisman, Hymie; Merali, Zul; Audet, Marie‐Claude

doi:10.1016/j.bbi.2017.06.009

Cited by 89 publications

(65 citation statements)

References 65 publications

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“…promoted depressive states among alcoholics and Turicibacter spp . were less abundant in mice susceptible to anxiety‐like effects . However, in this study, we have not observed significant correlations of these species with alcohol‐induced neurobehavioral changes.…”

Section: Discussioncontrasting

confidence: 86%

Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice

Wang

Dong³

et al. 2018

BioFactors

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Alcohol addiction can cause brain dysfunction and many other diseases. Recently, increasing evidences have suggested that gut microbiota plays a vital role in regulating alcohol addiction. However, the exact mechanism has not yet been elucidated. Here, our study focused on the intestinal bacteria alternations and their correlations with alcohol‐induced neuropsychic behaviors. When consuming alcohol over 3‐week period, animals gradually displayed anxiety/depression‐like behaviors. Moreover, 16S rRNA sequencing showed significant intestinal microflora dysbiosis and distinct community composition. Actinobacteria and Cyanobacteria were both increased at the phylum level. At the genus level, Adlercreutzia spp., Allobaculum spp., and Turicibacter spp. were increased whereas Helicobacter spp. was decreased. We also found that the distances in inner zone measured by open field test and 4% (v/v) alcohol preference percentages were significantly correlated with Adlercreutzia spp. The possible mechanisms were explored and we found the expression of brain‐derived neurotrophic factor (BDNF) and α1 subunit of γ‐aminobutyric acid A receptor (Gabra1) were both decreased in prefrontal cortex (PFC). Especially, further correlation analyses demonstrated that decreased Adlercreutzia spp. was positively correlated with alcohol preference and negatively correlated with anxiety‐like behavior and BDNF/Gabra1 changes in PFC. Similar relationships were observed between Allobaculum spp. and alcohol preference and BDNF changes. Helicobacter spp. and Turicibacter spp. were also correlated with PFC BDNF and hippocampus Gabra1 level. Taken together, our study showed that gut microbiota dysbiosis during chronic alcohol exposure was closely correlated with alcohol‐induced neuropsychic behaviors and BDNF/Gabra1 expression, which provides a new perspective for understanding underlying mechanisms in alcohol addiction. © 2018 BioFactors, 45(2):187–199, 2019

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Section: Discussioncontrasting

confidence: 86%

Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice

Wang

Dong³

et al. 2018

BioFactors

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“…Recent years has seen a growing interest in the potential contribution of microbiota-gut-brain axis signalling in both the aetiology and treatment of stress-related disorders (Foster et al 2017;Rea et al 2017). For instance, preclinical studies have revealed that chronic stress results in an altered gut microbial composition (Bailey et al 2011;Bharwani et al 2017;Burokas et al 2017;Galley et al 2017;Marin et al 2017;Szyszkowicz et al 2017;Dunphy-Doherty et al 2018). In addition, various microbiota-targeted interventions are able to ameliorate chronic stress-induced deficits in mice, which include the administration of live bacterial strains (probiotics) (Bharwani et al 2017;Marin et al 2017), as well as the supplementation of host-indigestible dietary fibres that are fermented by the gut microbiota (prebiotics) .…”

Section: Introductionmentioning

confidence: 99%

Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations

Wouw

Boehme

Lyte

et al. 2018

The Journal of Physiology

552

309

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There is a growing recognition of the involvement of the gastrointestinal microbiota in the regulation of physiology and behaviour. Microbiota-derived metabolites play a central role in the communication between microbes and their host, with short-chain fatty acids (SCFAs) being perhaps the most studied. SCFAs are primarily derived from fermentation of dietary fibres and play a pivotal role in host gut, metabolic and immune function. All these factors have previously been demonstrated to be adversely affected by stress. Therefore, we sought to assess whether SCFA supplementation could counteract the enduring effects of chronic psychosocial stress. C57BL/6J male mice received oral supplementation of a mixture of the three principle SCFAs (acetate, propionate and butyrate). One week later, mice underwent 3 weeks of repeated psychosocial stress, followed by a comprehensive behavioural analysis. Finally, plasma corticosterone, faecal SCFAs and caecal microbiota composition were assessed. SCFA treatment alleviated psychosocial stress-induced alterations in reward-seeking behaviour, and increased responsiveness to an acute stressor and in vivo intestinal permeability. In addition, SCFAs exhibited behavioural test-specific antidepressant and anxiolytic effects, which were not present when mice had also undergone psychosocial stress. Stress-induced increases in body weight gain, faecal SCFAs and the colonic gene expression of the SCFA receptors free fatty acid receptors 2 and 3 remained unaffected by SCFA supplementation. Moreover, there were no collateral effects on caecal microbiota composition. Taken together, these data show that SCFA supplementation alleviates selective and enduring alterations induced by repeated psychosocial stress and these data may inform future research into microbiota-targeted therapies for stress-related disorders.

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“…Psychological stress is involved in the initiation, maintenance, and aggravation of IBS. Several lines of evidence have demonstrated the impact of stress on the gut microbiota, but the precise mechanisms remain incompletely understood. Interestingly, mice exposed to chronic social defeat stress exhibited reduced representation of pathways involved in the synthesis and metabolism of short‐chain fatty acids (SCFAs) .…”

Section: Introductionmentioning

confidence: 99%

Beneficial effect of butyrate‐producing Lachnospiraceae on stress‐induced visceral hypersensitivity in rats

Zhang

Song

Wang

et al. 2018

J of Gastro and Hepatol

207

157

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Background and Aim Emerging evidence indicates that psychological stress is involved in the pathogenesis of irritable bowel syndrome, which is characterized by visceral hypersensitivity and may be accompanied by gut dysbiosis. However, how such stress contributes to the development of visceral hypersensitivity is incompletely understood. Here, we aimed to investigate the influence that stress‐induced microbial changes exert on visceral sensitivity, as well as the possible underlying mechanisms associated with this effect. Methods Male Sprague–Dawley rats underwent chronic water avoidance stress (WAS) to induce visceral hypersensitivity. Visceral sensitivity, colonic tight junction protein expression, and short‐chain fatty acids of cecal contents were measured. Fecal samples were collected to characterize microbiota profiles. In a separate study, oral gavage of Roseburia in WAS rats was conducted to verify its potential role in the effectiveness on visceral hypersensitivity. Results Repeated WAS caused visceral hypersensitivity, altered fecal microbiota composition and function, and decreased occludin expression in the colon. Stressed rats exhibited reduced representation of pathways involved in the metabolism of butyrate and reduced abundance of several operational taxonomic units associated with butyrate‐producing bacteria, such as Lachnospiraceae. Consistently, supplementation with Roseburia hominis, a species belonging to Lachnospiraceae, significantly increased cecal butyrate content. Moreover, Roseburia supplementation alleviated visceral hypersensitivity and prevented the decreased expression of occludin. Conclusions Reduction in the abundance of butyrate‐producing Lachnospiraceae, which is beneficial for the intestinal barrier, was involved in the formation of visceral hypersensitivity. R. hominis is a potential probiotic for treating stress‐induced visceral hypersensitivity.

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Implications of the gut microbiota in vulnerability to the social avoidance effects of chronic social defeat in male mice

Cited by 89 publications

References 65 publications

Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice

Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice

Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations

Beneficial effect of butyrate‐producing Lachnospiraceae on stress‐induced visceral hypersensitivity in rats

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