“…Sometimes, the family of the patient must make a big effort to understand the criticality of the clinical picture and the nurse plays a fundamental role which is recognized by the international literature, to help family members to understand the situation, through continuous reports and talks. 1,22,23 Generally, for treatment of hospitalized patients with sepsis, it is fundamental: 6 i) to disseminate information on the new guidelines to the team members; ii) to include discussion of the guidelines during unit clinical care meetings and clinical rounds; iii) to constitute a multidisciplinary team and outline a timeline for implementing the guidelines; iv) to use the new guidelines as a performance improvement initiative for the Intensive Care Unit as well as noncritical care areas to improve recognition and treatment of patients with sepsis. Specific areas include: i) aid in the early identification of sepsis including recognizing patients at risk for developing sepsis (patients who are elderly, immunocompromised, patients with surgical/invasive procedures, indwelling catheters, mechanically ventilated patients) and monitoring physical assessment parameters including vital signs and perfusion status (urine output, mental status changes, skin color); ii) to provide comprehensive sepsis treatment (circulatory support with fluids, inotropes, and vasopressors; supportive treatment with oxygenation and ventilation; antibiotic administration; sepsis guideline recommendation measures; monitor and report patient response to treatment); iii) to promote patient and family centered care (patient and family teaching, addressing the needs of families of critically ill patients, setting goals of care, and holding family care conferences to discuss goals of care).…”