Implications of triclosan for female fertility: results from the National Health and Nutrition Examination Survey, 2013–2016

Beroukhim, Gabriela; Kayani, Jehanzeb; Taylor, Hugh S.; Pal, Lubna

doi:10.1016/j.xfre.2022.06.002

Cited by 6 publications

(20 citation statements)

References 46 publications

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“…Urinary TCS levels in NHANES were measured using solid phase extraction coupled with high-phase liquid chromatography and tandem mass spectrometry, with the lower limit of assay detection being 2.27 ng/mL. 18 Triclosan measurements were adjusted for urinary creatinine to account for urine concentration, using the ratio of TCS to urinary creatinine. 33 For this article, urinary TCS measures refer to creatinine-adjusted values (expressed in ng/mg creatinine), as previously reported.…”

Section: Study Populationmentioning

confidence: 99%

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Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016

Beroukhim,

Kayani,

Taylor

et al. 2023

Menopause

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Objective To examine the association between urinary levels of triclosan (TCS), a ubiquitous endocrine disrupter, and menopausal status using the National Health and Nutrition Examination Survey. Methods A retrospective cross-sectional study from 2003 to 2016 was conducted among US female participants who completed the reproductive health questionnaire and provided TCS-level measurements. Exposure was assessed by urinary TCS levels adjusted for urinary creatinine; levels were log-transformed to achieve normal distribution for parametric analyses. Menopausal status was based on participants' responses to: “What is the reason that you have not had a period in the past 12 months?” Multivariable linear regression analyses examined the association between creatinine-adjusted urinary TCS levels and menopausal status after adjusting for age at survey completion, body mass index, race, ethnicity, and smoking exposure. Results Of the final sample of female participants (n = 6,958), 40% identified as postmenopausal, of whom 60% had experienced natural menopause, and of these, 11% had become menopausal at under 40 years of age. Triclosan levels correlated positively with advancing age (r = 0.09, P < 0.001) and inversely with body mass index (r = −0.09, P < 0.001). Smoking exposure was associated with significantly lower TCS levels (P < 0.001). Compared with premenopausal women, postmenopausal women had significantly higher log-transformed, creatinine-adjusted TCS levels (mean, −1.22 ± 1.79 vs −1.51 ± 1.79 ng/mg creatinine; P < 0.001). Triclosan levels were unrelated to the duration of menopause and did not differ between women who underwent natural versus surgical menopause, and premature menopause versus menopause at 40 years or older. In unweighted multivariate linear regression analyses, menopausal status was independently associated with higher urinary TCS levels after adjusting for covariates (β coefficient, 0.17; 95% CI, 0.020-0.323; P = 0.026). Conclusions In a nationally representative sample, postmenopausal status was associated with higher urinary TCS levels, observations that merit further investigation into potential exposures and health consequences.

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Section: Study Populationmentioning

confidence: 99%

“…10 Despite stricter regulations on TCS usage, more than 70% of the female NHANES participants from 2013 to 2016 had detectable levels of urine TCS. 18 Generally, females tend to exhibit higher TCS levels than males 6 ; however, whether TCS levels differ by stage of reproductive aging has not been previously examined.…”

mentioning

confidence: 99%

Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016

Beroukhim,

Kayani,

Taylor

et al. 2023

Menopause

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“…Elsewhere in this issue, Beroukhim et al. ( 3 ) present the results of a retrospective, cross-sectional study in which the investigators analyzed data from the National Health and Nutrition Examination Survey along with urine triclosan (5-chloro-2-2,4-dichloro phenoxy phenol [TCS]) measurements from 2013–2016. The investigators report a 35% lesser likelihood of meeting criteria for infertility if levels of TCS were undetectable compared with those with detectable levels with a magnitude of association between TCS and presumed infertility increasing with the TCS concentration quartile ( 3 ).…”

mentioning

confidence: 99%

“…The half-life of TCS is only 21 hours; therefore, the use of urinary levels as a surrogate measure of long-term exposure may be limited. Additionally, when the analysis was restricted to only those of reproductive age (aged 18–45 years), the significance of this association did not persist ( 3 ).…”

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confidence: 99%

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Everyday endocrine disruptors: challenges in investigation and interpretation

Lee¹,

Kawwass²

2022

F&S Reports

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Dietary and lifestyle‐related factors behind delayed conception in females

Rizvi,

Rabail,

Munir

et al. 2024

Food Science & Nutrition

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Delayed conceiving is a failure of a female to attain clinical pregnancy within a year without the use of contraception or any precautionary measure. The females of reproductive age (20–49 years) are the sufferers, that is, about 1.5 million or 10% of couples globally are facing this issue. Delayed conception can be caused by several reasons including diet, lifestyle, and genetic and clinical problems. Deficiencies or overconsumption of any nutrient may also cause delayed conception in females. Dietary deficits such as iron, iodine, zinc, folate, and vitamin D reduce the ovarian reserve. Heavy metals such as copper, manganese, lead, and cadmium also have an impact on fertility. Overconsumption of fast foods and nonhome‐made foods increases the likelihood of infertility by 2–3. Smoking, physical activity, age, polycystic ovary syndrome (PCOS), obesity, and depression have all been considered lifestyle and clinical factors. If women have a sedentary lifestyle, too much exercise or obesity both contribute to infertility. In clinical factors, type 1 diabetes, insulin resistance, and hypertension mainly cause infertility. Our focus in this review is on the studies probe that how these variables contributed to delayed conception and how it can be controlled to help combat infertility. Prevention from delayed conception involves consuming a healthy and balanced diet that contains essential nutrients engaging in physical activity and abstaining from smoking, PCOS, and medical issues.

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Implications of triclosan for female fertility: results from the National Health and Nutrition Examination Survey, 2013–2016

Cited by 6 publications

References 46 publications

Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016

Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016

Everyday endocrine disruptors: challenges in investigation and interpretation

Dietary and lifestyle‐related factors behind delayed conception in females

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