Importance of collateral circulation in coronary heart disease

Berry, Colin; Balachandran, Kanarath; L’Allier, Philippe L.; Lespérance, Jacques; Bonan, Raoul; Oldroyd, Keith G.

doi:10.1093/eurheartj/ehl446

Cited by 126 publications

(87 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the exact mechanisms underlying the protective effects of the presence of collaterals are unclear, several factors might play a role. The collateral circulation has demonstrated clinical benefit regarding smaller infarct size, preservation of cardiac function after acute (re-) infarctions, and reduction in post-infarct ventricular dilatation [14][15][16][17][18][19][20][21][22]. Following a total coronary occlusion, residual perfusion to the myocardium persists through native coronary collaterals that open when an intercoronary pressure gradient between the source and recipient vessel develops.…”

Section: Discussionmentioning

confidence: 99%

Effect of collaterals on deaths and re-infarctions in patients with coronary artery disease: a meta-analysis

et al. 2012

View full text Add to dashboard Cite

Background It is generally believed that there is a beneficial effect of collaterals on death and re-infarction statistics in patients with coronary artery disease (CAD) but studies to date are small and inconsistent. Objective To meta-analyse the studies published in this field in order to obtain more powerful information. Methods We searched Medline and major journals (2000 to 2011) for studies evaluating the effect of coronary collaterals on mortality. Publication bias, lack of heterogeneity, and lack of robustness were assessed using the standard procedures for such purposes. Results A total of 10 studies describing mortality, enrolling 6791 participants, were included in this analysis. In patients with collateralisation a significant relation with reduced mortality was seen compared with those without collateralisation, at an odds ratio of 0.47, p<0.0001, and a reduction in deaths and re-infarctions at 0.54, p<0.0001. Some publication bias, some heterogeneity and some lack of robustness were demonstrated. A meta-regression with the odds ratios of the presence of traditional atherosclerotic risk factors as predictors and the odds ratios of mortality and the composite deaths and re-infarctions as outcome showed no relationships.Conclusions In CAD patients from the post-percutaneous coronary intervention era the presence of collaterals reduced mortality by 0.47 (p<0.0001) and deaths and re-infarctions by 0.54 (p<0.0001). Furthermore, in the present meta-data, the atherosclerotic risk factors were no more present in patients with collaterals than they were in those without.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of collaterals on deaths and re-infarctions in patients with coronary artery disease: a meta-analysis

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In obstructive coronary artery disease (CAD), coronary collateral arteries serve as alternative conduits for blood flow to the myocardial tissue supplied by the obstructed vessel(s) [2]. Therefore, they are a "natural coronary arterial bypass" to the region supplied by the obstructed vessels [6,11,21].…”

Section: Introductionmentioning

confidence: 99%

Coronary artery dominance dependent collateral development in the human heart

Ajayi

Vanker²,

Satyapal

2017

Folia Morphol

View full text Add to dashboard Cite

show abstract

“…Recent advances in the modernization of coronary intensive care units, the use of beta blockers, coronary bypass surgery, fibrinolytic therapy and primary coronary angioplasty and similar treatment methods has resulted in important declines in mortality rates due to coronary heart disease (1,2). A well-developed collateral artery also restricts the infarction area during acute myocardial infarction (MI) and prevents the occurrence of Q wave MI, left ventricular aneurysm and coronary failure.…”

Section: Introductionmentioning

confidence: 99%

“…As is known, inflammation has a significant role in the progression of atherosclerosis. For this reason, an examination of inflammatory markers that can affect the development of collateral arteries is important (2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

The relationship between coronary collateral artery development and inflammatory markers

Oğuz¹,

Atmaca²,

Ozdol³

et al. 2014

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: This study aims to show the effect of myeloperoxidase (MPO), hsCRP, TNF-alpha values and leukocyte count on the development of coronary collateral arteries in patients with severely diseased coronary arteries. Methods: Current study is an observational cross-sectional study. In the study, 295 patients who had functional obstruction or total coronary occlusion at least 1 month on their angiograms were included. We divided the study population into two groups according to their collateral grade as good collateral (Group 1) (169 patients) and poor collateral (Group 2) (126 patients). Multiple logistic regression analysis was used for independent variables associated with the coronary collateral grade. Results: History of stable angina pectoris was statistically more prevalent in good collateral group (61.5% and 48.4%, p=0.025). Furthermore, MPO activation was higher in good collateral group and the difference was statistically significant (3.7 U/mL and 3.0 U/mL p=0.001). In multiple logistic regression analysis, stable angina pectoris [OR 1.7, 95% CI (1.05-2.8), p=0.03] and high MPO levels [OR 2.7,3), p<0.001] were found to be independent predictors of good collateral development. Conclusion: We think that proinflammatory enzymes and cytokines released from these cells rather than inflammatory cells themselves may play an important role on the collateral development. (Anadolu Kardiyol Derg 2014; 14: 336-41)

show abstract

Importance of collateral circulation in coronary heart disease

Abstract: Coronary collateral anastomoses represent a prognostically important adaptive response in patients with CHD. Therapeutic augmentation of collaterals with emerging biological therapies represents a desirable goal for treating CHD patients.

Cited by 126 publications

References 101 publications

Effect of collaterals on deaths and re-infarctions in patients with coronary artery disease: a meta-analysis

Effect of collaterals on deaths and re-infarctions in patients with coronary artery disease: a meta-analysis

Coronary artery dominance dependent collateral development in the human heart

The relationship between coronary collateral artery development and inflammatory markers

Contact Info

Product

Resources

About