Importance of Gardnerella vaginalis as an aetiological agent in bacterial vaginosis.

Abstract

Correspondence tics without improvement. We treated her successfully with local applications of piperazine solution for only eight days, and more than 18 months elapsed since without any recurrence. In chronic cases of sterile pyuria, therefore, urine should be examined for parasites. If the ova or larvae of E vermicularis are found treatment should be by local irrigation ofthe urethra and bladder and vaginal application of piperazine salts.The most probable source of repeated urinary tract infections in our patient was the vagina and not the intestinal tract. This explanation is based on three observations: (1) stools and parianal swabs from her and her husband were repeatedly negative for E vermicularis, (2)

Vaginal microflora in healthy women with Gardnerella vaginalis

“…29 Further, in 93% to 100% of women diagnosed with bacterial vaginosis, G. vaginalis is colonized, and the colony count is high. 4,[9][10][11] Therefore, a finding of negative G. vaginalis culture will preclude the presence of bacterial vaginosis.…”

“…1 With the development of selective media for G. vaginalis, this bacteria has been isolated with detection rates of 14% to 69% in normal controls [2][3][4][5][6][7][8] and at rates of 93% to 100% in subjects with bacterial vaginosis. 4,[9][10][11][12][13][14] The bacterial concentration of G. vaginalis in these two populations has been reported to be approximately 5 log 10 and 7 log 10 colony-forming units (CFU) per g of vaginal secretion, respectively.…”

Gardnerella vaginalis triggers NLRP3 inflammasome recruitment in THP-1 monocytes

“…and overgrowth of anaerobic and facultative bacteria including Gardnerella vaginalis (Holst et al, 1987). Although the bacterium is observed in asymptomatic women, it occurs in up to 96% of BV cases (Borchardt et al, 1989). G. vaginalis has also consistently been observed in conjunction with gynecological and obstetric disease states including pelvic inflammatory disease, endometritis, intra-amniotic infection, miscarriage, premature labor, preterm delivery, fetal brain injury, and acquisition of HIV and other sexually transmitted infections (Turovskiy et al, 2011).…”

Gardnerella vaginalis: characteristics, clinical considerations, and controversies

“…G. vaginalis occurred in numbers exceeding 106 CFU/ml in 77 of 78 clue cell-positive vaginal discharges (17). Further, between 93 and 100% of women suffering from bacterial vaginosis were heavily colonized by G. vaginalis (8,18,65,89,92,94,167,170,226), and the numbers of CFU in samples from diseased vaginas were much higher than in healthy vaginas according to most (5,182,213,219,233), but not all (25,137), authors. As expected, the finding of a negative G. vaginalis culture had a 97% predictive value for exclusion of bacterial vaginosis (5,46).…”

“…Its role in adherence of G. vaginalis to epithelial cells of the vagina has been demonstrated (203,214,236). I suggest that this microcapsular material may also be responsible in part for the clustering of cells that occurs in broth cultures (18,37,59).…”