Importance of intensive blood pressure control in type 2 diabetes: Mechanisms, treatments and current guidelines

Marre, Michel

doi:10.1111/dom.13975

Cited by 8 publications

(11 citation statements)

References 107 publications

(130 reference statements)

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“…There is substantial overlap between T2D and hypertension in etiology and illness mechanisms. Hypertension and diabetes substantially share common pathways, such as obesity, inflammation, oxidative stress, insulin resistance, and mental stress [ 43 , 44 ]. Patients with diabetes experience increased peripheral artery resistance caused by vascular remodeling and increased body fluid volume associated with insulin resistance–induced hyperinsulinemia and hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

“…This approach may provide information suitable for the user’s clinical condition and may improve self-management efficiency and the clinical course through personalized intervention [ 48 ]. Lifestyle changes, such as dietary habits and following exercise recommendations, are crucial for persons with diabetes and hypertension, even when pharmacological treatment is required [ 43 , 49 ]. Further, guidance on lifestyle changes must be provided for people with diabetes and hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…BP management presents a possible course to control BG and improve the patient’s well-being. Reducing BP is more helpful for people with than without diabetes in terms of absolute cardiovascular risk [ 43 ]. Previous studies have revealed the beneficial effect of BP treatment in people with high-risk diabetes: attaining standard glycemic control resulted in a decreased risk of cardiovascular events, including heart failure [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

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Blood Pressure Monitoring as a Digital Health Tool for Improving Diabetes Clinical Outcomes: Retrospective Real-world Study

Fundoiano-Hershcovitz¹,

Bacher²,

Ritholz³

et al. 2022

J Med Internet Res

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Background Remote data capture for blood glucose (BG) or blood pressure (BP) monitoring and the use of a supportive digital app are becoming the model in diabetes and hypertension chronic care. One of the goals in chronic condition management is to increase awareness and generate behavioral change in order to improve outcomes in diabetes and related comorbidities, such as hypertension. In addition, there is a lack of understanding of the association between BG and BP levels when using digital health tools. Objective By applying a rigorous study framework to digital health data, this study investigated the relationship between BP monitoring and BG and BP levels, as well as a lagged association between BP and BG. We hypothesized that during the first 6 months of BP monitoring, BG and BP levels would decrease. Finally, we suggested a positive association between BP levels and the following month’s BG levels. Methods In this retrospective, real-world case-control study, we extracted the data of 269 people with type 2 diabetes (T2D) who tracked their BG levels using the Dario digital platform for a chronic condition. We analyzed the digital data of the users who, in addition to BG, monitored their BP using the same app (BP-monitoring [BPM] group, n=137) 6 months before and after starting their BP monitoring. Propensity score matching established a control group, no blood pressure monitoring (NBPM, n=132), matched on demographic and baseline clinical measures to the BPM group. A piecewise mixed model was used for analyzing the time trajectories of BG, BP, and their lagged association. Results Analysis revealed a significant difference in BG time trajectories associated with BP monitoring in BPM and NBPM groups (t=–2.12, P=.03). The BPM group demonstrated BG reduction improvement in the monthly average BG levels during the first 6 months (t=–3.57, P<.001), while BG did not change for the NBPM group (t=0.39, P=.70). Both groups showed similarly stable BG time trajectories (B=0.98, t=1.16, P=.25) before starting the use of the BP-monitoring system. In addition, the BPM group showed a significant reduction in systolic (t=–6.42, P<.001) and diastolic (t=–4.80, P<.001) BP during the first 6 months of BP monitoring. Finally, BG levels were positively associated with systolic (B=0.24, t=2.77, P=.001) and diastolic (B=0.30, t=2.41, P=.02) BP. Conclusions The results of this study shed light on the association between BG and BP levels and on the role of BP self-monitoring in diabetes management. Our findings also underscore the need and provide a basis for a comprehensive approach to understanding the mechanism of BP regulation associated with BG.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Blood Pressure Monitoring as a Digital Health Tool for Improving Diabetes Clinical Outcomes: Retrospective Real-world Study

Fundoiano-Hershcovitz¹,

Bacher²,

Ritholz³

et al. 2022

J Med Internet Res

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show abstract

“…Marre [ 10 ] fasste den aktuellen Wissenstand zur Hypertoniediagnostik und -therapie insbesondere für Diabetespatienten zusammen (u. a. Tab. 2 ).…”

Section: Qualität Der Blutdruckeinstellungunclassified

Neues zu Hypertonie und Diabetes

Lindner

2021

Diabetologe

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“…In this series of articles in this supplement, Zoungas, Knudsen & Cooper, Chalmers & Woodward, and Marre outline the history and the findings on the ADVANCE trial in some detail, covering explicitly the lessons learned about glycaemic control, renal disease, observational studies, and blood pressure (BP) control …”

mentioning

confidence: 99%

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Matthews

2020

Diabetes Obesity Metabolism

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Importance of intensive blood pressure control in type 2 diabetes: Mechanisms, treatments and current guidelines

Cited by 8 publications

References 107 publications

Blood Pressure Monitoring as a Digital Health Tool for Improving Diabetes Clinical Outcomes: Retrospective Real-world Study

Blood Pressure Monitoring as a Digital Health Tool for Improving Diabetes Clinical Outcomes: Retrospective Real-world Study

Neues zu Hypertonie und Diabetes

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