2011
DOI: 10.1128/aem.02492-10
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Importance of Porins for Biocide Efficacy against Mycobacterium smegmatis

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Cited by 26 publications
(20 citation statements)
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“…A lower level of the porin OmpF in the E. coli membrane decreased the strain susceptibility to BACs (64). A causal relationship between a disinfectant product containing BACs and the downregulation of porins was demonstrated for Mycobacterium smegmatis; knockout mutants for Msp porins were less susceptible to the biocide than was the wild type (68). The use of a disinfectant formulation by the authors, however, limits the extent to which the observed effect can be attributed to BACs, other components of the formula, or the mixture.…”
Section: Microbial Mechanisms Of Tolerance and Resistancementioning
confidence: 97%
“…A lower level of the porin OmpF in the E. coli membrane decreased the strain susceptibility to BACs (64). A causal relationship between a disinfectant product containing BACs and the downregulation of porins was demonstrated for Mycobacterium smegmatis; knockout mutants for Msp porins were less susceptible to the biocide than was the wild type (68). The use of a disinfectant formulation by the authors, however, limits the extent to which the observed effect can be attributed to BACs, other components of the formula, or the mixture.…”
Section: Microbial Mechanisms Of Tolerance and Resistancementioning
confidence: 97%
“…Selection of an appropriate biocide depends on the presence of other chemical compounds in liquids, such as anti-corrosion formulations and, above all, on their antimicrobial activity at high inoculum density. Periodical microbiological examination resistance (even eight fold in the porin triple mutant of Mycobacterium smegmatis) to biocides and enhance their survival in the hostile environment [49]. The biocide resistance of biofilm-grown M. immunogenum has appeared to be 3-to 100-fold higher than that of the planktonic mycobacteria [5].…”
Section: Control Of the Microbial Load In Mwfsmentioning
confidence: 99%
“…Concerns over the emergence of globally-circulating virulent clones of M. abscessus complex species 25 coupled to reports of rapidly growing mycobacteria presenting resistance to aldehyde-based products, including recently, during the largest outbreak ever reported of M. abscessus complex infections in Brazil, 34,6 and the finding that some of the mechanisms of resistance to aldehydes evolved by NTM may confer cross-resistance to other disinfectants and antibiotics, 17,19 led us to systematically investigate the susceptibility profile of a collection of GTA-resistant M. chelonae and M. abscessus subsp. massiliense isolates to various disinfectant chemistries using two different testing methods.…”
Section: Discussionmentioning
confidence: 99%
“…17 Reduced porin expression in the rapidly-growing Mycobacterium species, Mycobacterium smegmatis , has indeed been associated with increased resistance not only to aldehyde-based products but also quaternary ammonium compounds, isothiazolinones, methylenbisoxazolidine and lipophilic biocides such as polyhexamethylene biguanine and octenidine dihydrochloride, in addition to multiple antibiotics. 1719 Furthermore, five studies reported that GTA-resistant M. chelonae and M. abscessus strains isolated either experimentally or from endoscope washer disinfectors presented an increased resistance to peracetic acid, peroxygen, sodium dichloroisocyanurate or quaternary ammonium compounds. 1314,2022 …”
Section: Introductionmentioning
confidence: 99%