Important Roles of Oligo- and Polysaccharides against SARS-CoV-2: Recent Advances

Iravani, Siavash; Varma, Rajender S.

doi:10.3390/app11083512

Cited by 26 publications

(25 citation statements)

References 91 publications

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“…Oligosaccharides can fight against pathogenic viruses by the direct interaction with the virus (negative charge on the surface of viruses), inhibiting the invasion and adsorption of viruses, and also hindering the obstruction of the viral transcription and replication via direct interference ( Iravani and Varma, 2021 ). A recent study investigated the antiviral effects of resveratrol oligosaccharides for SARS-CoV-2.…”

Section: Potential Application Of Prebiotics For the Prevention Of Co...mentioning

confidence: 99%

Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis

Yang

Liu

et al. 2022

Front. Pharmacol.

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Coronavirus disease 2019 (COVID-19) can disrupt the gut microbiota balance, and patients usually have intestinal disorders. The intestine is the largest immune organ of the human body, and gut microbes can affect the immune function of the lungs through the gut-lung axis. Many lines of evidence support the role of beneficial bacteria in enhancing human immunity, preventing pathogen colonization, and thereby reducing the incidence and severity of infection. In this article, we review the possible approach of modulating microbiota to help prevent and treat respiratory tract infections, including COVID-19, and discuss the possibility of using probiotics and prebiotics for this purpose. We also discuss the mechanism by which intestinal micro-flora regulate immunity and the effects of probiotics on the intestinal micro-ecological balance. Based on this understanding, we propose the use of probiotics and prebiotics to modulate gut microbiota for the prevention or alleviation of COVID-19 through the gut-lung axis.

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Section: Potential Application Of Prebiotics For the Prevention Of Co...mentioning

confidence: 99%

Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis

Yang

Liu

et al. 2022

Front. Pharmacol.

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“…Pectin polysaccharides from natural plants cell walls may modulate immunity against SARS-CoV-2 through the release of cytokines such as TNF-α and IL-6, anti-inflammatory activity, and the increased phagocytosis of macrophages. Additionally, they may achieve this through the production of nitrous oxide, reactive oxygen species formation, and activation of signaling pathways including Toll-like 4, type A hijacker receptor, NF-κB, and glucan receptor [119,120].…”

Section: Modified Pectin and Galectin-3 Response To The Cytokine Storm Effectmentioning

confidence: 99%

Potential Roles of Modified Pectin Targeting Galectin-3 against Severe Acute Respiratory Syndrome Coronavirus-2

Odun-Ayo

Reddy

2021

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Modified pectin (MP) is a bioactive complex polysaccharide that is broken down into smaller fragments of units and used as an oral dietary supplement for cell proliferation. MP is safe and non-toxic with promising therapeutic properties with regard to targeting galectin-3 (GAL-3) toward the prevention and inhibition of viral infections through the modulation of the immune response and anti-inflammatory cytokine effects. This effect of MP as a GAL-3 antagonism, which has shown benefits in preclinical and clinical models, may be of relevance to the progression of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in coronavirus disease 2019 patients. The outbreak of emerging infectious diseases continues to pose a threat to human health. Further to the circulation of multiple variants of SARS-CoV-2, an effective and alternative therapeutic approach to combat it has become pertinent. The use of MP as a GAL-3 inhibitor could serve as an antiviral agent blocking against the SARS-CoV-2-binding spike protein. This review highlights the potential effects of MP in viral infections, its proposed role as a GAL-3 inhibitor, and the associated function concerning a SARS-CoV-2 infection.

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“…Various therapeutic strategies and interventions are being advanced to identify an effective drug for COVID‐19 (coronavirus disease 2019) therapy, this disease being instigated by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). 1 , 2 , 3 , 4 Nanotechnology‐based strategies can be deployed for designing and developing innovative antivirals delivery systems, nanovaccines and (nano)biosensors. 5 , 6 Indeed, nanomaterials and nanoarchitectures with unique physicochemical properties can assist in the development of diagnostic tools with sensitivity/selectivity, simplicity and scalability for expeditious and economical detection of SARS‐CoV‐2.…”

Section: Introductionmentioning

confidence: 99%

Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

Rabiee

Ahmadi

Soufi

et al. 2022

J of Chemical Tech & Biotech

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The application of quantum dots (QDs) for detecting and treating various types of coronaviruses is very promising, as their low toxicity and high surface performance make them superior among other nanomaterials; in conjugation with fluorescent probes they are promising semiconductor nanomaterials for the detection of various cellular processes and viral infections. In view of the successful results for inhibiting SARS‐CoV‐2, functional QDs could serve eminent role in the growth of safe nanotherapy for the cure of viral infections in the near future; their large surface areas help bind numerous molecules post‐synthetically. Functionalized QDs with high functionality, targeted selectivity, stability and less cytotoxicity can be employed for highly sensitive co‐delivery and imaging/diagnosis. Besides, due to the importance of safety and toxicity issues, QDs prepared from plant sources (e.g. curcumin) are much more attractive, as they provide good biocompatibility and low toxicity. In this review, the recent developments pertaining to the diagnostic and inhibitory potentials of QDs against SARS‐CoV‐2 are deliberated including important challenges and future outlooks. © 2022 Society of Chemical Industry (SCI).

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Important Roles of Oligo- and Polysaccharides against SARS-CoV-2: Recent Advances

Cited by 26 publications

References 91 publications

Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis

Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis

Potential Roles of Modified Pectin Targeting Galectin-3 against Severe Acute Respiratory Syndrome Coronavirus-2

Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

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