Important Targets and Inhibitors of Mycobacterium tuberculosis

TargetingMycobacterium tuberculosisiron-scavenging tools: a recent update on siderophores inhibitors

“…Type I NADH dehydrogenase is homologous to the complex I in mitochondria and is unnecessary for bacterial growth. 37,38 Electrons derived from NADH are released into the electron transport chain by NADH dehydrogenase, which reduces the menaquinone pool (MK/MKH 2 ). Also, the menaquinone pool can be reduced by electron donors via succinate dehydrogenase (SDH).…”

“…DNA inside the cell is in supercoiled form, which has to be relaxed before initiating new DNA strand synthesis. 38,107 In eukaryotic and prokaryotic organisms, type II DNA topoisomerases play a critical role in maintaining DNA function. M.tb DNA gyrase is a heterotetramer (A 2 B 2 ), which consists of two subunits domains, i.e., gyrase A (encoded by gyrA gene) and gyrase B (encoded by gyrB gene), and are involved in the maintenance of the DNA topology.…”

“…DNA gyrase carries out several cellular reactions, including the restoration of the removal of negative supercoiling of closed circular double-stranded DNA, fork movement, and resolution of catenated DNA. 38,109 Fluoroquinolones (FQs) showed antimycobacterial activity by interacting with the GyrA subunit of DNA gyrase and topoisomerase IV. Further, FQs block DNA replication, which leads to the accumulation of double-stranded DNA fragments.…”

“…DNA gyrase carries out several cellular reactions, including the restoration of the removal of negative supercoiling of closed circular double-stranded DNA, fork movement, and resolution of catenated DNA. 38,109…”