Imported schistosomiasis in Paris region of France: A multicenter study of prevalence and diagnostic methods

LeBlanc, Claire; Brun, Sophie; Bouchaud, Olivier; Izri, Arezki; Ok, Vichita; Caseris, Marion; Sorge, F.; Pham, Luu-Ly; Paugam, A.; Paris, Luc; Jauréguiberry, Stéphane; Bloch-Queyrat, Coralie; Boubaya, Marouane; Faye, Albert; Mariani, Patricia; Pontual, Loïc de

doi:10.1016/j.tmaid.2021.102041

Cited by 7 publications

(6 citation statements)

References 34 publications

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“…In relation to IHA, although the number of patients studied was small, we found a low sensitivity (44.4%) for the detection of Schistosoma spp. infection, which coincides with other studies such as that of Leblanc et al that showed a sensitivity of 48% in a study conducted in children coming from an endemic area in the previous 12 months or in autochthones after a stay of at least 3 months in an endemic area and skin contact with fresh water during the journey [ 10 ]. Additionally, Yameny, in a cross-sectional study in Egypt designed to evaluate the efficacy of this technique compared to microscopy, obtained a 42% sensitivity using 50 S. haematobium positive samples and 50 negative ones [ 29 ].…”

Section: Discussionsupporting

confidence: 90%

“…Beltrame et al in a study in Italy with African migrants, using microscopy as the gold standard, reported a sensitivity of 94% [ 16 ]. Leblanc et al found a sensitivity of 100% for Schistosoma ICT IgG-IgM ® in their study [ 10 ]. In a recent publication by Hoermann et al, ICT showed a sensitivity of 100% in patients with confirmed schistosomiasis, irrespective of species as S. mekongi and S. japonicum infections were included in addition to S. mansoni and S. haematobium [ 25 ].…”

Section: Discussionmentioning

confidence: 98%

“…These diagnoses may be delayed by language barriers, bureaucracy, access to health care, lack of knowledge of the disease amid health care personnel, poor symptomatology or diagnostic difficulties, among other causes [ 7 ]. Regarding schistosomiasis, an increasing number of publications present series of cases diagnosed in non-endemic areas [ 8 , 9 , 10 , 11 , 12 , 13 ], generally in migrants or people visiting these areas. On the other hand, outbreaks of autochthonous transmission of S. haematobium have recently been described in Corsica (France) and Almería (Spain) [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Accuracy of Three Serological Techniques for the Diagnosis of Imported Schistosomiasis in Real Clinical Practice: Not All in the Same Boat

et al. 2023

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Schistosomiasis is a neglected tropical disease despite of being a major public health problem affecting nearly 240 million people in the world. Due to the migratory flow from endemic countries to Western countries, an increasing number of cases is being diagnosed in non-endemic areas, generally in migrants or people visiting these areas. Serology is the recommended method for screening and diagnosis of schistosomiasis in migrants from endemic regions. However, serological techniques have a highly variable sensitivity. The aim of this study was to evaluate retrospectively the sensitivity of three different serological tests used in real clinical practice for the screening and diagnosis of imported schistosomiasis in sub-Saharan migrant patients, using the detection of schistosome eggs in urine, faeces or tissues as the gold standard. We evaluated three different serological techniques in 405 sub-Saharan patients with confirmed schistosomiasis treated between 2004 and 2022: an enzyme-linked immunosorbent assay (ELISA), an indirect haemagglutination assay (IHA) and an immunochromatographic test (ICT). The overall sensitivity values obtained with the different techniques were: 44.4% for IHA, 71.2% for ELISA and 94.7% for ICT, respectively. According to species, ICT showed the highest sensitivity (S. haematobium: 94%, S. mansoni: 93.3%; and S. intercalatum/guineensis: 100%). In conclusion, our study shows that Schistosoma ICT has the best performance in real clinical practice, when compared to ELISA and IHA, in both S. mansoni and S. haematobium infections.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Accuracy of Three Serological Techniques for the Diagnosis of Imported Schistosomiasis in Real Clinical Practice: Not All in the Same Boat

et al. 2023

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“…The authors' conclusion underlines the higher risk of induced malaria or schistosomiasis when travelling to Africa [4]. Among migrant children from Africa in Paris, the prevalence of schistosomiasis estimates to be 24.3%, whereas half of those cases are asymptomatic [5].…”

Section: Discussionmentioning

confidence: 91%

Imported parasitosis as a diagnostic challenge in Primary Healthcare Clinic in the non-endemic region — a case study of schistosomiasis in English Division student

Gałązka

Starownik

Kasztelan-Szczerbińska

et al. 2022

Medical Research Journal

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Schistosomiasis is a parasitosis, most commonly caused by Schistosoma mansoni or Schistosoma haematobium, eventually by other species from the genus Schistosoma (blood flukes). This study presents a case of schistosomiasis in an African-origin student cured in the Primary Healthcare Clinic (PHC) in Lublin, Poland.The young adult male patient from Zimbabwe, studying in Poland, presented to the PHC, due to pain in the left down quadrant of the abdomen, bloody stools, and a single episode of drooling with a blood-stained jelly-like mass, without fever. In blood tests, there was neutropenia, lymphocytosis and eosinophilia. In a colonoscopy, numerous lymphoid nodules were observed with small regions of mucosal erythema, faded vascular drawing, and delayed small contact bleeding.The patient had an elevated level of IgE (329,5 IU/mL; N < 158) and minor abnormalities in the proteinogram. Abdominal CT showed calcification of intestinal walls, suggesting infection of flukes from the Schistosoma genus. The result of histopathological examination confirmed the presence of structures interpreted as parasite eggs in intestinal crypts, lamina propria and the lumen of mesenteric vessels.It is of great importance, that general medicine physicians working in schistosomiasis non-endemic regions are aware and pay attention to various risks as well as provide referrals to advanced imaging and endoscopic procedures in patients with unusual health problems. Keeping in mind, that early signs and symptoms of schistosomiasis, and results of blood tests may remain unspecific in contrast to a more complex gastrointestinal diagnostic approach, a chance of early diagnosis and successful therapeutic intervention may be facilitated.

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“…In Paris, France, a survey conducted among both symptomatic and asymptomatic recently immigrated children estimated the prevalence of schistosomiasis at 24.3%, by using multiple tests [57].…”

Section: Importation Of Cases Of Human Schistosomiasis Into Europementioning

confidence: 99%

Schistosomiasis in Europe

Gabrielli

Djirmay

2023

Curr Trop Med Rep

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Purposeof Review The purpose of this review is to provide an overview of the burden of schistosomiasis in the European continent. It discusses three subjects: the endemic forms of non-human schistosomiasis in Europe; the introduction of transmission of human schistosomiasis into Europe; and the occurrence of imported cases of human schistosomiasis. Recent Findings Europe is not endemic for human schistosomiasis; nevertheless, it is affected by the disease in multiple ways, although the magnitude of the burden remains elusive because of gaps in surveillance and reporting. Summary Schistosomiasis is a global neglected disease prevalent in tropical and subtropical areas. As of 2022, it is estimated that 251 million people require preventive chemotherapy for schistosomiasis, 90% of whom live in Africa. In Europe, human schistosomiasis is frequently detected in migrants from endemic countries who reach the continent. Additionally, outbreaks due to local transmission can sporadically occur following the introduction of schistosomes in one of the many freshwater bodies in southern Europe where competent snail hosts are found. Finally, human cercarial dermatitis is frequently occurring in Europe, because of the presence of avian schistosomiasis in several countries across the continent. A stronger epidemiological surveillance and reporting system, coupled with more surveys on humans and snails, can contribute to better assess and characterize the burden of schistosomiasis in Europe.

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Imported schistosomiasis in Paris region of France: A multicenter study of prevalence and diagnostic methods

Cited by 7 publications

References 34 publications

Accuracy of Three Serological Techniques for the Diagnosis of Imported Schistosomiasis in Real Clinical Practice: Not All in the Same Boat

Accuracy of Three Serological Techniques for the Diagnosis of Imported Schistosomiasis in Real Clinical Practice: Not All in the Same Boat

Imported parasitosis as a diagnostic challenge in Primary Healthcare Clinic in the non-endemic region — a case study of schistosomiasis in English Division student

Schistosomiasis in Europe

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