2005
DOI: 10.1128/mcb.25.8.3019-3026.2005
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Imprinted Nesp55 Influences Behavioral Reactivity to Novel Environments

Abstract: Genomic imprinting results in parent-of-origin-dependent monoallelic expression of selected genes. Although their importance in development and physiology is recognized, few imprinted genes have been investigated for their effects on brain function. Gnas is a complex imprinted locus whose gene products are involved in early postnatal adaptations and neuroendocrine functions. Gnas encodes the stimulatory G-protein subunit Gs␣ and two other imprinted protein-coding transcripts. Of these, the Nesp transcript, exp… Show more

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Cited by 134 publications
(115 citation statements)
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“…Such demand may be imposed either directly, through behaviors that solicit forms of investment as in Angelman syndrome, or indirectly, through selforiented, non-social behavior that precludes or delays physical independence, requiring mothers or others to provide longer-term, more highly-intensive care. This 18 hypothesis is concordant with several lines of evidence, including: (1) accelerated brain and body growth in young children with autism and increased relative effects from paternally-expressed imprinted genes (Crespi and Badcock 2008), (2) imprinted gene effects on reaction to novelty, and dispersal, in mice (Isles et al 2002;Plagge et al 2005), (3) a higher incidence of autism in males, who are more costly than females to rear (Gibson and Mace 2003;Rickard et al 2007;Tamimi et al 2003), (4) myriad reports of close and sustained, if atypical, relationships between mothers and their autistic children (e. g., Hoffman et al 2009), and (5) temperaments of autistic children that involve higher rates of activity, impulsivity, and non-compliance (e. g., Garon et al 2009).…”
Section: Autism and Attachmentsupporting
confidence: 66%
“…Such demand may be imposed either directly, through behaviors that solicit forms of investment as in Angelman syndrome, or indirectly, through selforiented, non-social behavior that precludes or delays physical independence, requiring mothers or others to provide longer-term, more highly-intensive care. This 18 hypothesis is concordant with several lines of evidence, including: (1) accelerated brain and body growth in young children with autism and increased relative effects from paternally-expressed imprinted genes (Crespi and Badcock 2008), (2) imprinted gene effects on reaction to novelty, and dispersal, in mice (Isles et al 2002;Plagge et al 2005), (3) a higher incidence of autism in males, who are more costly than females to rear (Gibson and Mace 2003;Rickard et al 2007;Tamimi et al 2003), (4) myriad reports of close and sustained, if atypical, relationships between mothers and their autistic children (e. g., Hoffman et al 2009), and (5) temperaments of autistic children that involve higher rates of activity, impulsivity, and non-compliance (e. g., Garon et al 2009).…”
Section: Autism and Attachmentsupporting
confidence: 66%
“…3 The open-field. The apparatus consisted of a square-shaped arena (750  750 mm 2 , length  width), constructed of white plastic and illuminated evenly at 15 lux 50 . Subjects were placed facing the centre of one of the walls and allowed to explore the apparatus for 10 min.…”
Section: Methodsmentioning
confidence: 99%
“…The maze, positioned 300 mm above the floor and illuminated evenly at 15 lux, was constructed of white Perspex and consisted of two exposed open arms (175  78 mm 2 , length  width) and two equally sized enclosed arms, which had 150-mm high walls 50 . Equivalent arms were arranged opposite to one another (Fig.…”
Section: Methodsmentioning
confidence: 99%
“…Mice carrying a maternally derived targeted allele of the gene Nesp showed a reduced propensity to explore a novel environment. Nesp is expressed only maternally, and is found in discrete locations in the brain including the noradrenergic locus coeruleus (Plagge et al 2005), a key brain area in the control of reactivity to novel stimuli (Sara et al 1995;Cole et al 1988). In mice at least, it appears that the paternal interest may be to limit risk-taking (by silencing the paternal copy of Nesp), while it is in the maternal interest to promote these behaviours.…”
Section: Sex-biased Dispersal Intragenomic Conflict and Social Behavmentioning
confidence: 99%
“…Although caution needs to be used when discussing a behavioural construct as complex as 'risktaking', a recent study by us suggests that imprinted genes may impact on one aspect of this behaviour, namely exploration of a novel environment (Plagge et al 2005). Mice carrying a maternally derived targeted allele of the gene Nesp showed a reduced propensity to explore a novel environment.…”
Section: Sex-biased Dispersal Intragenomic Conflict and Social Behavmentioning
confidence: 99%