Improve endothelialization of metallic cardiovascular stent via femtosecond laser induced micro/nanostructure dependent cells proliferation and drug delivery control

Liang, Chunyong; Tian, Yang; Zou, Xianrui; Hu, Yuecheng; Zhou, Huan; Yang, Lei; Wang, Hongshui

doi:10.1016/j.colsurfb.2022.112376

Cited by 11 publications

(4 citation statements)

References 38 publications

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“…Different surface patterns were created using femtosecond laser energies, influencing the drug-loading capacity and release profile. The rapamycin-eluting stent, with a specific surface pattern, showed promising potential for endothelialization and resistance to restenosis, offering a novel approach for vascular plaque management [ 37 ].…”

Section: Restenosismentioning

confidence: 99%

“…Nanoparticle therapy offers enhanced drug-delivery capabilities and theranostic applications for targeted treatment strategies. Additionally, innovative approaches utilizing drug-loaded coatings and femtosecond laser surface treatments [ 37 ] show potential for reducing restenosis risk and enhancing endothelialization. Non-invasive drug-delivery systems, including liposomes and nanoparticles, have demonstrated improvements in atherosclerotic lesions and restenosis rates following stenting.…”

Section: Restenosismentioning

confidence: 99%

“…Sirolimus nanoparticles have been investigated for their potential in reducing inflammation response and restenosis rates in lower extremity arteries after balloon injury [ 35 , 36 ]. Poly(lactic-co-glycolic acid) (PLGA)-coated stents loaded with antiproliferative agents enhance endothelialization and reduce restenosis risk after stent deployment [ 37 ]. Additionally, drug-loaded nanoparticles show promise in the treatment of severe and life-threatening atherosclerotic lesions in coronary heart disease (CHD) [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

2023

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Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally. Despite significant advancements in the development of pharmacological therapies, the challenges of targeted drug delivery to the cardiovascular system persist. Innovative drug-delivery systems have been developed to address these challenges and improve therapeutic outcomes in CVDs. This comprehensive review examines various drug delivery strategies and their efficacy in addressing CVDs. Polymeric nanoparticles, liposomes, microparticles, and dendrimers are among the drug-delivery systems investigated in preclinical and clinical studies. Specific strategies for targeted drug delivery, such as magnetic nanoparticles and porous stent surfaces, are also discussed. This review highlights the potential of innovative drug-delivery systems as effective strategies for the treatment of CVDs.

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Section: Restenosismentioning

confidence: 99%

Section: Restenosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

2023

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“…The advance of nanotechnology in biomaterials provides new tools for cell adhesion. Rapid re-endothelialization can be achieved via different nanotechnologies, such as the use of core-shell nano/micro particles as a multi-drug/bioactive molecules delivery system [290,291], creating different nanostructured stent surfaces (e.g., change of surface topography) [292,293], and by virtue of bioactive ligand-mediated cell adhesion [294].…”

Section: The Advance Of Cardiovascular Stent: Polymer-metal Stents En...mentioning

confidence: 99%

Polymer–Metal Composite Healthcare Materials: From Nano to Device Scale

et al. 2022

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Metals have been investigated as biomaterials for a wide range of medical applications. At nanoscale, some metals, such as gold nanoparticles, exhibit plasmonics, which have motivated researchers’ focus on biosensor development. At the device level, some metals, such as titanium, exhibit good physical properties, which could allow them to act as biomedical implants for physical support. Despite these attractive features, the non-specific delivery of metallic nanoparticles and poor tissue–device compatibility have greatly limited their performance. This review aims to illustrate the interplay between polymers and metals, and to highlight the pivotal role of polymer–metal composite/nanocomposite healthcare materials in different biomedical applications. Here, we revisit the recent plasmonic engineered platforms for biomolecules detection in cell-free samples and highlight updated nanocomposite design for (1) intracellular RNA detection, (2) photothermal therapy, and (3) nanomedicine for neurodegenerative diseases, as selected significant live cell–interactive biomedical applications. At the device scale, the rational design of polymer–metallic medical devices is of importance for dental and cardiovascular implantation to overcome the poor physical load transfer between tissues and devices, as well as implant compatibility under a dynamic fluidic environment, respectively. Finally, we conclude the treatment of these innovative polymer–metal biomedical composite designs and provide a future perspective on the aforementioned research areas.

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Optimising metallic coatings strategies for enhanced surface performance of bioresorbable polymeric stents

Sousa,

Amaro,

Piedade

2025

Applied Surface Science Advances

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Improve endothelialization of metallic cardiovascular stent via femtosecond laser induced micro/nanostructure dependent cells proliferation and drug delivery control

Cited by 11 publications

References 38 publications

Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

Polymer–Metal Composite Healthcare Materials: From Nano to Device Scale

Optimising metallic coatings strategies for enhanced surface performance of bioresorbable polymeric stents

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