Improved antitumor activity of epirubicin-loaded CXCR4-targeted polymeric nanoparticles in liver cancers

Sun, Da; Pan, Guozheng; Long, Hao; Zhang, Jian; Xue, Qingze; Wang, Peng; Yuan, Qing-Zhong

doi:10.1016/j.ijpharm.2015.12.066

Cited by 35 publications

(21 citation statements)

References 24 publications

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“…Nano-prodrugs with diameter larger than 200 nm are known to induce non-specific scavenging by monocytes and the reticuloendothelial system. 34 Hence, these results indicated that TSPCs-based self-assemblies may possess prolonged circulation time and enhance tumor accumulation in vivo.…”

Section: Stability Of Tspcs-based Self-assembliesmentioning

confidence: 83%

<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy</p>

Yang¹,

Du²,

Cui³

et al. 2019

IJN

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Background: Doxorubicin (DOX) is one of the most effective treatments for hepatocellular carcinoma (HCC), but is restricted by its poor pharmacokinetics. Herein, we exploited efficient targeted drug delivery systems and they have been found to be a worthy strategy for liver cancer therapy. Materials and methods: We investigated polymeric nanoparticles which were synthesized based on host-guest interaction between β-cyclodextrin and benzimidazole. The properties of nanoparticles with regard to size/shape, encapsulation efficiency, and drug release were investigated using conventional experiments. Cell proliferation assay in vitro, cell uptake assay, and cell apoptosis analysis were used to investigate cytotoxicity, uptake, and mechanism of targeted supramolecular prodrug complexes (TSPCs)-based self-assemblies and supramolecular prodrug complexes (SPCs)-based self-assemblies. Results: The pH-sensitive lactobionic acid (LA)-modified pH-sensitive self-assemblies were synthesized successfully. The results of in vitro released assay showed that the accelerated released of DOX from TSPCs-based self-assemblies with the decrease of pH value. When TSPCs-based self-assemblies were taken up by HepG2 cells, they demonstrated a faster release rate under acidic conditions and proved to have higher cytotoxicity than in the presence of LA. A mechanistic study revealed that TSPCs-based self-assemblies inhibited liver cell proliferation by inducing cell apoptosis. Conclusion: The pH-sensitive nanocomplex, as liver-targeted nanoparticles, facilitated the efficacy of DOX in HepG2 cells, offering an appealing strategy for the treatment of HCC.

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Section: Stability Of Tspcs-based Self-assembliesmentioning

confidence: 83%

<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy</p>

Yang¹,

Du²,

Cui³

et al. 2019

IJN

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“…Moreover, we compared the performance of the prepared epirubicin-capped silver NPs with other epirubicin-loaded systems. According to the data summarized in Table 2, our system exhibits superior cytotoxic activity with lower IC 50 values [28,29,30].…”

Section: Resultsmentioning

confidence: 99%

One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells

Ding

Chen

2019

Pharmaceutics

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Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag+ to Ag0. The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and infrared spectroscopy. The results showed that a layer of polymer epirubicin had formed around the silver nanoparticle, which was 30-40 nm in diameter. We further investigated the antitumor activity of the prepared epirubicin-capped silver nanoparticle, and the half maximal inhibitory concentration (IC50) against Hep G2 cells was 1.92 μg/mL, indicating a good antitumor property of the nanoparticle at low dosage.

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“… Di-Wen et al (2016) encapsulated epirubicin in polymeric nanoparticles and conjugated them to LFC 131 peptide on its surface. They developed a liver-targeted drug delivery system and investigated anti-tumor activity in vitro and in vivo ( Di-Wen et al, 2016 ). A linear type of FC131 peptide (D-Tyr-Arg-Arg-2-Nal-Gly) was used to target C-X-C receptor type 4 (CXCR4) that is overexpressed by hepatocellular carcinoma.…”

Section: Nanotechnology Involvement In the Delivery Of Antimicrobial mentioning

confidence: 99%

“…In vitro with human hepatic carcinoma cells (HepG2), the study found that the targeted nanoparticles had a threefold uptake compared to the uncoated. Further, in vivo a biodistribution of FC131 peptide-targeted epirubicin-loaded PLGA nanoparticles was compared to uncoated, showing a higher concentration of the drug in the liver even after 24 h ( Di-Wen et al, 2016 ), demonstrating the effectiveness of targeted delivery.…”

Section: Nanotechnology Involvement In the Delivery Of Antimicrobial mentioning

confidence: 99%

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

et al. 2018

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Antimicrobial peptides are sequences of amino acids, which present activity against microorganisms. These peptides were discovered over 70 years ago, and are abundant in nature from soil bacteria, insects, amphibians to mammals and plants. They vary in amino acids number, the distance between amino acids within individual peptide structure, net charge, solubility and other physical chemical properties as well as differ in mechanism of action. These peptides may provide an alternative treatment to conventional antibiotics, which encounter resistance such as the peptide nisin applied in treating methicillin resistant Staphylococcus aureus (MRSA) or may behave synergistically with known antibiotics against parasites for instance, nisin Z when used in synergy with ampicillin reported better activity against Pseudomonas fluorescens than when the antibiotic was alone. AMPs are known to be active against viruses, bacteria, fungi and protozoans. Nanotechnology is an arena which explores the synthesis, characterization and application of an array of delivery systems at a one billionth of meter scale. Such systems are implemented to deliver drugs, proteins, vaccines, and peptides. The role of nanotechnology in delivering AMPs is still at its early development stage. There are challenges of incorporating AMPs into drug delivery system. This review intends to explore in depth, the role of nanotechnology in delivering AMPs as well as presenting the current advances and accompanying challenges of the technology.

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Improved antitumor activity of epirubicin-loaded CXCR4-targeted polymeric nanoparticles in liver cancers

Cited by 35 publications

References 24 publications

<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy</p>

<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy</p>

One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

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Improved antitumor activity of epirubicin-loaded CXCR4-targeted polymeric nanoparticles in liver cancers

Cited by 35 publications

References 24 publications

<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on &beta;-cyclodextrin for liver cancer-targeted therapy</p>

<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on &beta;-cyclodextrin for liver cancer-targeted therapy</p>

One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

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<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy</p>

<p>pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy</p>