Improved Blood Glucose Control by Insulin Therapy in Type 2 Diabetic Patients Has No Effect on Lipoprotein(a) Levels

Wolffenbuttel, Bruce H. R.; Leurs, Paul; Sels, J. P. J. E.; Rondas-Colbers, G. J. W. M.; Menheere, P. P. C. A.; Kruseman, A. C. Nieuwenhuijzen

doi:10.1111/j.1464-5491.1993.tb00093.x

Cited by 21 publications

(11 citation statements)

References 33 publications

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“…On the other hand, Lp(a) concentrations were not significantly correlated with insulin sensitivity (HOMA-IR) which is consistent with existing literature [43][44].…”

Section: Discussionsupporting

confidence: 82%

Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study

Antonopoulos

Mylonopoulou²,

Angelidi

et al. 2017

Diabetes Research and Clinical Practice

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Antonopoulos, S.; Mylonopoulou, M.; Angelidi, A.M.; Kousoulis, A.A.; Tentolouris, N. (2017) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The detected Lp(a) and MGP association in CKD4 patients may also represent the key to the complicated mechanism of their coexisting accelerated atherosclerosis and vascular calcification. ASSOCIATION OF MATRIX γ-CARBOXYGLUTAMIC ACID PROTEIN LEVELS WITH INSULIN RESISTANCE AND Lp(a) IN DIABETES : A CROSS-SECTIONAL STUDY

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“…On the other hand, Lp(a) concentrations were not significantly correlated with insulin sensitivity (HOMA-IR) which is consistent with existing literature [43][44].…”

Section: Discussionsupporting

confidence: 82%

Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study

Antonopoulos

Mylonopoulou²,

Angelidi

et al. 2017

Diabetes Research and Clinical Practice

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“…Elevated serum Lp(a) levels have been reported in NIDDM patients in comparison with non-diabetic subjects [ 18,19,28], but not in all studies [29]. The reasons for the elevated Lp(a) levels remain unclear: we [30] and others [ 181 have shown no effect of improved glycaemic control by insulin therapy in this patient group. Moreover, the distribution frequency of apo(a) isoforms in such patients proved not to be altered [IS].…”

Section: Discussionmentioning

confidence: 73%

Lipoprotein(a) levels in relation to diabetic complications in patients with non‐insuIin‐dependent diabetes

Heesen¹,

Wolffenbuttel²,

Leurs³

et al. 1993

Eur J Clin Investigation

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Abstract.The relationship between serum levels of lipoprotein(a) (Lp(a)) and the presence of chronic diabetic complications was studied in 194 patients with non-insulin-dependent diabetes mellitus (NIDDM; 75 males, 119 females; age 6 6 k 1 1 years; duration of diabetes, 11 (range 1-35) years). They were taking various treatments (diet alone, oral hypoglycaemic agents and/or insulin). Metabolic status and prevalence of diabetic complications were assessed by detailed history, physical examination, laboratory analysis and ECG. Average metabolic control was moderate (HbAI, 8.2f 1.7%). Median serum Lp(a) level was 183 U 1-' (range 8-2600 U I-'), which was significantly higher than in control subjects of comparable age (median 101; range 8-1747 U I-'; P

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“…Similar results have also been reported by Wolffenbuttel et al . [27] They reported that Lp(a) levels were elevated in diabetics as compared to non-diabetic subjects of similar age but did not change with insulin and there was no correlation with the degree of metabolic control and changes in Lp(a) levels. However, Alagozlu et al .…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein (a) in type 2 diabetes mellitus: Relation to LDL:HDL ratio and glycemic control

Singla¹,

Kaur²,

Kaur³

et al. 2009

Int J Diab Dev Ctries

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BACKGROUND:Increased lipoprotein (a) [Lp (a)] concentrations are predictive of coronary artery disease (CAD). Type 2 diabetes mellitus also leads to dyslipidemia, like elevated triglyceride levels and low HDL levels, which are known risk factors for CAD. This study was designed to investigate the levels of Lp (a) in type 2 diabetic patients and their association with LDL: HDL ratio and glycemic control.MATERIALS AND METHODS:The study included 60 patients of type 2 diabetes and 50 age and sex matched controls. The Lp(a) levels in the diabetic group were compared with the control group and the relationship between the Lp(a) levels and LDL: HDL ratio was evaluated. Diabetic group was further divided into three subgroups according to levels of glycated hemoglobin. Lp(a) levels and glycated hemoglobin in controlled and uncontrolled diabetes mellitus were also compared to find out any correlation between them. Statistical analysis was done using the students ‘t’ test and Chi square test.RESULTS:Lp(a) levels were found to be significantly increased in the diabetic group as compared to the control group (P< 0.001). LDL: HDL ratio was also increased in the diabetic group as compared to the control group. Lp(a) levels showed no association with LDL: HDL ratio and degree of glycemic control in these patients.CONCLUSIONS:The results of the present study suggest that Lp(a) levels are increased in type 2 diabetic patients. The elevated Lp(a) levels do not reflect the glycemic status and are also independent of increase in LDL:HDL ratio suggesting different metabolic pathways and the genetic connection for LDL and Lp(a).

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Improved Blood Glucose Control by Insulin Therapy in Type 2 Diabetic Patients Has No Effect on Lipoprotein(a) Levels

Cited by 21 publications

References 33 publications

Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study

Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study

Lipoprotein(a) levels in relation to diabetic complications in patients with non‐insuIin‐dependent diabetes

Lipoprotein (a) in type 2 diabetes mellitus: Relation to LDL:HDL ratio and glycemic control

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