Improved bone-forming functionality on diameter-controlled TiO2 nanotube surface

Brammer, Karla S.; Oh, Seunghan; Cobb, Christine J.; Bjursten, Lars Magnus; Heyde, Henri van der; Jin, Sung‐Ho

doi:10.1016/j.actbio.2009.05.008

Cited by 561 publications

(504 citation statements)

References 33 publications

Supporting

Mentioning

426

Contrasting

Unclassified

Order By: Relevance

“…[48] Such spacing provided a distribution of binding sites which was ineffective for focal contact formation and the cells had to extend their filopodia in order to find more adsorbed proteins. [55,56] In contrast to the TNT surfaces, the cells on disordered TMS substrates had relatively uniform access to adsorbed proteins due to the homogeneous localization of proteins on the surface. When anchored, filopodia converts to the flat membrane protrusions called lamellipodia.…”

Section: Cell Morphologymentioning

confidence: 99%

The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration

Zhukova

Hiepen

Knaus

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Surface structuring of titanium-based implants is known to modulate the behavior of adherent cells, but the influence of different nanotopographies is poorly understood. The aim is to investigate preosteoblast proliferation, adhesion, morphology, and migration on surfaces with similar surface chemistry but distinct nanotopographical features. Sonochemical treatment and anodic oxidation are employed to fabricate disordered, mesoporous titania (TMS) and ordered titania nanotubular (TNT) topographies on titanium, respectively. Morphological evaluation reveals that cells are polygonal and well-spread on TMS, but display an elongated, fibroblast-like morphology on TNT surfaces, while they are much flatter on glass. Both nanostructured surfaces impair cell adhesion, but TMS is more favorable for cell growth due to its support of cell attachment and spreading in contrast to TNT. A quantitative wound healing assay in combination with live-cell imaging reveals that cell migration on TMS surfaces has a more collective character than on other surfaces, probably due to a closer proximity between neighboring migrating cells on TMS. The results indicate distinctly different cell adhesion and migration on ordered and disordered titania nanotopographies, providing important information that can be used in optimizing titanium-based scaffold design to foster bone tissue growth and repair while allowing for the encapsulation of drugs into porous titania layer

show abstract

Section: Cell Morphologymentioning

confidence: 99%

The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration

Zhukova

Hiepen

Knaus

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Nanotubular surfaces significantly improved bone bonding strength by as much as nine-fold compared with gritblasted surfaces, and histological analysis revealed greater bone-implant contact and collagen type I expression confirming the better in vivo behaviour of titania nanotubes (Bjursten et al, 2008;von Wilmowsky et al, 2008). It has been also shown that various nanomorphological features of titania nanotubes, such as length, diameter, wall thickness, have a major impact on the cellular reponses, providing the evidence that cells are susceptible to nanoscale dimesions (Brammer et al, 2009;Park et al, 2009). Besides, nanotubular structures on titanium provide a suitable infrastructure for loading and subsequent releasing of antibiotics (Aninwene et al, 2008;Popat et al, 2007b) or for immobilizing biosignalling molecules for better osseointegration (Balasundaram et al, 2007).…”

Section: Nanotopographical Modification Of Titanium Surfacesmentioning

confidence: 76%

Osseointegration and Bioscience of Implant Surfaces - Current Concepts at Bone-Implant Interface

Ramazanoğlu¹,

Oshida²

2011

Implant Dentistry - A Rapidly Evolving Practice

View full text Add to dashboard Cite

“…In another study, it was shown that the oxide layer adsorbed fibronectin promoted osteoblast attachment and osteointegration through binding of adsorbed fibronectin to surface-expressed osteoblast integrins [104]. Studies also reported the influence of surface nanotopography on the enhanced expression of osteogenic markers [105][106][107].…”

Section: Surface Modification Of 3d Printed Structuresmentioning

confidence: 93%

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Nune

Misra

2017

Sci. China Mater.

View full text Add to dashboard Cite

We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.

show abstract

Improved bone-forming functionality on diameter-controlled TiO2 nanotube surface

Cited by 561 publications

References 33 publications

The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration

The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration

Osseointegration and Bioscience of Implant Surfaces - Current Concepts at Bone-Implant Interface

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Contact Info

Product

Resources

About