Improved cardioprotective effects of hesperidin solid lipid nanoparticles prepared by supercritical antisolvent technology

Saad, Suma; Ahmad, Iqbal; Kawish, S.M.; Khan, Urooj A; Ahmad, Farhan Jalees; Ali, Asgar; Jain, Gaurav K.

doi:10.1016/j.colsurfb.2019.110628

Cited by 48 publications

(21 citation statements)

References 28 publications

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“…al., 2020;Lee, et.al., 2010) (Table 2). Both diosmin and hesperidin also reported for its activity to prevent and or suppress cardiac myocytes (Saad, et. al., 2020), hepatic cells (Tabeshpour, et.…”

Section: Resultsmentioning

confidence: 99%

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The Chemopreventive Potential of Diosmin and Hesperidin for COVID-19 and Its Comorbid Diseases

Utomo¹,

Ikawati

Putri³

et al. 2020

Indones J Cancer Chemoprevent

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The COVID-19 becomes worse with the existence of comorbid diseases such as cardiovascular diseases, metabolic syndromes, inflammation, degenerative diseases, as well as cancer. Therefore, a comprehension approach is needed to combat such comorbid conditions, not only focusing on the virus infection and replication but also directed to prevent the raising comorbid symptoms. This study analyzed the potential natural compounds, especially diosmin and hesperidin, as an anti-SARS-CoV-2 and chemopreventive agent against several COVID-19 comorbid diseases by using an in-silico method. Diosmin and hesperidin together with other natural compounds and existing viral drugs (lopinavir, nafamostat, and comastat) were docked into several proteins involved in SARS-CoV-2 infection and replication namely SARS-CoV-2 protease (PDB:6LU7), spike glycoprotein-RBD (PDB:6LXT), TMPRSS2, and PD-ACE2 (PDB:6VW1) using MOE software. The interaction properties were determined under docking score values. The result exhibited that diosmin and hesperidin performed superior interaction with all the four proteins compared to the other compounds, including the existing drugs. Moreover, under literature study, diosmin and hesperidin also elicit good chemopreventive properties against cardiovascular disorder, lung and kidney degeneration, as well as cancer development. In conclusion, diosmin and hesperidin possess high opportunity to be used for the COVID-19 and its the comorbid diseases as chemopreventive agents.Keywords: chemoprevention, COVID-19, diosmin, hesperidin, SARS-CoV-2 infection

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Section: Resultsmentioning

confidence: 99%

“…al., 2020 TNF-, COX-II and MPO and caspase-3 Shalkami, et. al., 2017 Cardioprotective creatine kinasemuscle/brain, cardiac troponin I and cardio histopathological scores Saad, et. al., 2020 Hepatoprotective Cardioprotective Nephroprotective IL-1 , IL-6, TNFand antioxidant enzymes Abdael-Daim, et.…”

Section: Resultsmentioning

confidence: 99%

The Chemopreventive Potential of Diosmin and Hesperidin for COVID-19 and Its Comorbid Diseases

Utomo¹,

Ikawati

Putri³

et al. 2020

Indones J Cancer Chemoprevent

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“…Different drug delivery systems have been developed to encapsulate hesperitin or hesperidin, such as polymeric nanoparticles [12,14] and lipid nanoparticles [28][29][30]. Even if in these studies using high-energy emulsification methods have been commonly reported the successful application of nanocarriers containing flavanones, low-energy methods are more rarely applied to produce lipid nanoparticles although low-energy approaches are considered simple and reproducible methods without using device and/or organic solvent.…”

Section: Lipid Nanoparticles Have Been Usually Produced By High-energy or Low-energymentioning

confidence: 99%

Preparation and cytotoxicity of lipid nanocarriers containing a hydrophobic flavanone

Simão

Honorato

Gobo

et al. 2020

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Hesperetin is a flavanone with recognized biological activities. However, such activities are limited due to its restricted aqueous solubility and stability. In this regard, the main aim of this study was to develop and characterize lipid nanocarriers containing hesperetin.Nanostructured lipid carriers (NLC) were prepared using phase inversion temperature method and characterized by size, polydispersity index (PdI), zeta potential, physical stability, TEM analysis, encapsulation efficiency, in vitro release, and in vitro cytotoxic effect in cell line. Lipid nanocarriers presented diameter below 80 nm, narrow PdI (< 0.2), and negative zeta potential (-20 mV). Accelerated stability studies of NLC demonstrated good physical stability for a period of 12 months. According to TEM, NLC were almost spherical with particle size < 100 nm and homogeneous size distribution. DSC curves showed that formulations presented lipid core with a higher degree of crystalline disorder.Lipid nanocarriers were able to entrap hesperitin with efficiency 72.7 % (±0.92). In vitro release studies confirmed that NLC could modulate hesperetin release during 72 h. In vitro cytotoxicity assay of hesperitin-loaded NLC on T98G glioblastoma grade IV cells presented significant cytotoxic effect. Therefore, NLC were able to encapsulate successfully hesperetin and demonstrated excellent in vitro cytotoxicity on glioblastoma cells.

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“…In the last few years, some studies have been published about hesperidin nanoparticles. Among the produced nanoparticles containing hesperidin are polysaccharide [15,16], nanocrystals [17], inorganic nanoparticles [18][19][20] nanoemulsions [21][22][23], liposomes [24], solid lipid nanoparticles [25], nanosuspensions [26], magnetic [27] and protein nanoparticles [11].…”

Section: Introductionmentioning

confidence: 99%

Optimized Chitosan-Coated Gliadin Nanoparticles Improved the Hesperidin Cytotoxicity over Tumor Cells

Filho

Machado

Diedrich

et al. 2021

Braz. arch. biol. technol.

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Hesperidin is a natural compound which is found in citric fruits and presents antitumor and antimicrobial activities. However, the in vivo efficacy of Hesperidin is reduced due to its low oral bioavailability. Protein-based nanoparticles have been applied to improve biological parameters of drugs and natural compounds. Gliadin is a monomeric protein present in wheat. In this study, gliadin-based nanoparticles containing hesperidin were obtained by desolvation technique and a Taguchi orthogonal array design was employed to optimize the formulation. The independent variables were set as concentration of CaCl2 (0.5; 1 or 2%) and stabilizing agent (Pluronic F68, Tween 80 or sodium caseinate). The dependent variables consisted of mean diameter, polydispersity index, zeta potential, and encapsulation efficiency. The results showed significant effects on the dependent variables when 1% CaCl2 and Pluronic F68 were used. The optimized formulation was coated with chitosan to increase the physical stability of the nanoparticles. The final nanoparticles presented a mean diameter of 321 nm and polydispersity index of 0.217, and spherical shape. After coating, the Zeta potential was +21 mV, and the encapsulation efficiency was 73 %. The in vitro release assay showed that about 98% of the drug was released from the nanoparticles after 48 h. Moreover, HIGHLIGHTS A Taguchi design optimized the development of hesperidin-loaded gliadin nanoparticles. A chitosan-coating was added to improve the physical stability of nanoparticles. Nanoparticles reduced the hesperidin cytotoxicity over healthy Vero cells. Nanoparticles improved the hesperidin cytotoxicity over tumor cells.

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Improved cardioprotective effects of hesperidin solid lipid nanoparticles prepared by supercritical antisolvent technology

Cited by 48 publications

References 28 publications

The Chemopreventive Potential of Diosmin and Hesperidin for COVID-19 and Its Comorbid Diseases

The Chemopreventive Potential of Diosmin and Hesperidin for COVID-19 and Its Comorbid Diseases

Preparation and cytotoxicity of lipid nanocarriers containing a hydrophobic flavanone

Optimized Chitosan-Coated Gliadin Nanoparticles Improved the Hesperidin Cytotoxicity over Tumor Cells

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