This contribution presents results of numerical simulations on a generic high-lift configuration. Properties of the computational grid are briefly described. The numerical simulations are performed with the DLR-TAU-Code at different angles of attack up to stall. The Menter-SST eddy viscosity turbulence model and the JHh-v2 Reynolds-Stress-Model are applied. Streamwise vortices arise at the edge of a slat, which is cut off in spanwise direction, and the corresponding edge of the clean nose. These vortices interact with the flow along the suction side of the wing. While proceeding downstream, a strong interaction between the vortices is observed for high angles of attack. The behavior of the vortex system and the influence on the high-lift performance of the configuration is characterized. In particular, the effect of the applied turbulence models of different types on the prediction of the vortex behavior is shown within this contribution.