Improved Classification of Urinary Tract Infection: Future Considerations

Smelov, Vitaly; Naber, Kurt G.; Johansen, Truls E. Bjerklund

doi:10.1016/j.eursup.2016.04.002

Cited by 77 publications

(76 citation statements)

References 38 publications

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“…Common symptoms of UTIs include burning sensation during urination, loss of bladder control, increased frequency of urination especially in small amounts, low back pain, cloudy and bloody or foul-smelling urine [7]. About 5% of girls and 2% of boys experience at least one incident of UTI up to the age of seven years [8,9]. Urinary tract infection is among the most prevailing infectious diseases with a consaiderable financial burden on society.…”

Section: Introductionmentioning

confidence: 99%

Bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among clinically suspected children attending at Felege-Hiwot Comprehensive and Specialized Hospital, Northwest Ethiopia. A prospective study

Fenta¹,

Dagnew

Belachew

et al. 2019

Preprint

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Background Urinary tract infection is one of the most common bacterial infections in children. Understanding the characteristics of uropathogens and their antimicrobial susceptibility pattern in a particular setting can provide evidence for appropriate management of cases. The aim of this study was to assess the bacterial profile of urinary tract infection, their antimicrobial susceptibility pattern and associated factors among clinically suspected children attending at Felege-Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia. Methods A hospital-based cross-sectional study was conducted from February-April, 2019. A systematic sampling technique was employed. A mid-stream urine sample was inoculated on cystine lactose electrolyte deficient media and incubated for 24-48 hours.Sub culturing was done on Mac-Conkey and blood agar. Antimicrobial susceptibility test was done on Muller-Hinton agar. A binary logistic regression model was used to see the association between dependent and independent factors.A p-value<0.05 at 95% CI was considered as statistically significant. Results The overall prevalence of urinary tract infection was 16.7% (95% CI 12.4-21.1). Both Gram-negative and Gram-positive bacterial isolates were recovered with the rate of 44/50 (88%) and 6 (12%) respectively. Among Gram-negative isolates, E.coli (56%) was the predominant while S. saprophyticus(6%) wasprevalent among Gram-positive bacterial isolates.Overall, a high level of resistance to ampicillin, Augmentin, and tetracycline was observed with the rate of 100%, 68.16%, 65.91% respectively. About 66% of multidrug resistance was observed (95% CI 52-78). Having a history of urinary tract infection (P-0.003, AOR 1.86-22.15) and male uncircumcision(p-0.00, AOR 5.5-65.35) were the independent variables that associate for urinary tract infections. Conclusion The prevalence of urinary tract infection among children was high and considerably a high proportion of multidrug resistance was observed in the present study. This result will have a significant impact on selection of appropriate antimicrobial agents for the treatment of urinary tract infection.

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Section: Introductionmentioning

confidence: 99%

Bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among clinically suspected children attending at Felege-Hiwot Comprehensive and Specialized Hospital, Northwest Ethiopia. A prospective study

Fenta¹,

Dagnew

Belachew

et al. 2019

Preprint

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“…The treatment of UTI can be classified into uncomplicated and complicated on the basis of their choice of treatment (Smelov et al, 2016;Sabra and Abdel-Fattah, 2012). Several studies (Gupta, 2003;Akoachere et al, 2012) haven shown geographic variations in aetiologic agents of UTIs and their resistance patterns to antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic susceptibility patterns of Uropathogenic Escherichia coli among patients with urinary tract infections in a tertiary care hospital in Maiduguri, North Eastern, Nigeria

Abdu¹,

Kachallah²,

Bolus³

2018

J. Biosci. Biotechnol. Discov.

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Escherichia coli (E. coli) has been identified as the most common uropathogenic bacterial pathogen with increasing resistance to antibiotics. Aetiology of urinary tract infections (UTI) and their antibiotic sensitivity patterns vary from time to time and across different areas. In Nigeria, studies on the prevalence and antimicrobial susceptibility patterns of clinical isolates from urinary tract infections are inadequate. Employing standardised microbiological methods, this study assessed the prevalence and antimicrobial susceptibility patterns of E. coli isolates from UTI in University of Maiduguri Teaching Hospital (a tertiary health care institution) in North Eastern, Nigeria. Uropathogenic E. coli (UPEC) accounted for 150 (62.50%) of 240 urine isolates. Lowest susceptibility was for Ampicillin 54 (36.0%), Ciprofloxacin 69 (46.0%) and Norfloxacin 72 (48.0%). More than 50% were susceptible to Levofloxacin and Streptomycin 71 (54.0%) each, Cefuroxime and Co-trimoxazole 78 (52.0%) each, while highest susceptibility was for Nitrofurantoin 117 (78.0%), Chloramphenicol 105 (70.0%) and Gentamicin 96 (64.0%). The isolates were commonly resistant to 9 (24.24%) of the ten (MARI of 0.9) classes of antimicrobial agents used in this study and all the isolates were multidrug-resistant. There is a need for proper surveillance and development of hospital specific antibiograms to inform appropriate empiric therapy of urinary tract infections.

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“…In order for NGS to become a routine form of diagnosis for infectious urological diseases, formal training in bioinformatics for clinical microbiologists would need to be considered, as would the development of secure, comprehensive databases, and the methodology of clinical reporting would have to be thought through clearly [24,25,26].…”

Section: Limitations Of Ngsmentioning

confidence: 99%

Metagenomics in diagnosis and improved targeted treatment of UTI

et al. 2019

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The genomic revolution has transformed our understanding of urinary tract infection (UTI). There has been a paradigm shift from the dogmatic statement that urine is sterile in healthy people, as we are becoming forever more familiar with the knowledge that bacterial communities exist within the urinary tracts of healthy people. Metagenomics can investigate broad populations of microbial communities, analyzing all the DNA present within a sample, providing comprehensive data regarding the state of the microenvironment of a patient's urinary tract. This permits medical practitioners to more accurately target organisms that may be responsible for disease-a form of 'precision medicine'. This paper explores the limitations of traditional methods of culture and sensitivity and delves into the recent studies involving new high-throughput genomic technologies in urological research, demonstrating the advances made in the role of urinary microbiome in a whole spectrum of pathologies from urinary tract infection, to prostate cancer. Finally, we discuss the challenges that must be overcome for such technology to become widely used in clinical practice.

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Improved Classification of Urinary Tract Infection: Future Considerations

Cited by 77 publications

References 38 publications

Bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among clinically suspected children attending at Felege-Hiwot Comprehensive and Specialized Hospital, Northwest Ethiopia. A prospective study

Bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among clinically suspected children attending at Felege-Hiwot Comprehensive and Specialized Hospital, Northwest Ethiopia. A prospective study

Antibiotic susceptibility patterns of Uropathogenic Escherichia coli among patients with urinary tract infections in a tertiary care hospital in Maiduguri, North Eastern, Nigeria

Metagenomics in diagnosis and improved targeted treatment of UTI

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