Improved control of long-term anticoagulant therapy.

Eastham, R. D.

doi:10.1136/bmj.2.5601.337

Cited by 10 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The therapeutic range of 50 to 70 seconds, based on the incidence of haemorrhage when soya bean and bentonite was used (Eastham, 1968), was found to correspond to 44-57 seconds when Bell and Alton phospholipid was used.…”

Section: Resultsmentioning

confidence: 96%

“…A time of 70 seconds, found to be critical in indicating potential risk of haemorrhage (Eastham, 1968), could be expressed as ratio values ranging between 1-6 and 2-1, wider than the therapeutic ranges chosen by Drs Pearce and Sekar (1973), depending on the normal control values found. Similar criticism can be levelled at the results of Drs Pearce and Sekar, their method of APTT estimation also having a wide normal range (26-40 seconds).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…(Eastham, 1968), was found to correspond to 44-57 seconds when Bell and Alton phospholipid was used.…”

mentioning

confidence: 99%

See 3 more Smart Citations

In defence of APTT control of long-term anticoagulant therapy.

Eastham¹

1973

J Clin Pathol

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…(Eastham, 1968), was found to correspond to 44-57 seconds when Bell and Alton phospholipid was used.…”

mentioning

confidence: 99%

See 2 more Smart Citations

In defence of APTT control of long-term anticoagulant therapy.

Eastham¹

1973

J Clin Pathol

View full text Add to dashboard Cite

“…The results for Thrombofax Activated are given in parallel with the 'standardized reagent'. Individual patient's blood Alderson, Poller, and Thomson (1970) (Hemker, Veltkamp, and Loeliger, 1968 Eastham (1968) has recommended the cephalin time as being more valuable than the Quick test in the regulation of long-term anticoagulant administration.…”

Section: Oral Anticoagulant Treatmentmentioning

confidence: 99%

The partial thromboplastin (cephalin) time test

Poller¹,

Thomson²

1972

J Clin Pathol

View full text Add to dashboard Cite

SYNOPSIS Nine partial thromboplastin (cephalin) reagents have been compared in a parallel investigation of groups of patients on 'long-term' anticoagulants, a group with moderate haemophilia, and patients on heparin infusion.Results with the seven commercial reagents and a human cephalin extract have been correlated with those of a specially prepared and standardized reference preparation of human brain origin. The comparison was similar in principle to that of the prothrombin time thromboplastin standardization using the British Comparative Thromboplastin (BCT).Results, which for comparative purposes were expressed as ratio of patients' cephalin times to control cephalin times, varied greatly in all three groups. In the oral anticoagulant group some of the commercial reagents were particularly insensitive to the 'intrinsic' clotting defect. The correlation between the 'standardized preparation' and the other reagents was not good and the use of a reference cephalin material for quality control of cephalin time tests does not appear promising.In moderate haemophilia the commercial reagents were either relatively poor 'at picking out the clotting defect compared with the 'standardized preparation' or gave such a bad endpoint that the results were not dependable. The poor endpoint also limited the dependability of the results of all but the 'standardized preparation' and two of the commercial reagents in controlling heparin administration.

show abstract

Die partielle Thromboplastinzeit

Averdunk

Braun

1972

Blut

View full text Add to dashboard Cite

Improved control of long-term anticoagulant therapy.

Cited by 10 publications

References 5 publications

In defence of APTT control of long-term anticoagulant therapy.

In defence of APTT control of long-term anticoagulant therapy.

The partial thromboplastin (cephalin) time test

Die partielle Thromboplastinzeit

Contact Info

Product

Resources

About