Improved delivery of cromolyn from oral proliposomal beads

Phospholipid-based solid drug formulations for oral bioavailability enhancement: A meta-analysis

“…Having an oral bioavailability of <1% in humans, cromoglicic acid was being formulated into proliposomal beads with DSPC, cholesterol and polysorbate 80 using spray-coating method by (Deshmukh et al, 2008). Consequently, the cumulative amounts of cromoglicic acid transported across time were increased by 3.5-and 7-fold in elevated rat sac and Caco-2 cells respectively.…”

Controlled release application of multilamellar vesicles: a novel drug delivery approach

“…The use of proliposomes represents an alternative to conventional liposomal formulations (Kumar et al, 2001;Brocks & Betageri 2002;Deshmukh et al, 2008). Proliposomes are a dry, freeflowing powder which forms a MLV suspension when it comes in contact with water (Payne et al, 1986).…”

Review of current trends in enhancing bioavailability of poorly water soluble drugs by liposomal interventions

“…For example, oral administration of protein-or polypeptide-loaded liposomes has been shown to give rise to enhanced absorption of active biomacromolecules [3], [6], [7]. Incorporation of poorly permeable small molecule drugs into liposomes also yielded improved oral absorption [8], [9], [10]. In particular, for poorly water-soluble drugs, substantial enhancement in bioavailability or in vivo efficacy has been observed following liposomal encapsulation [11], [12], [13].…”