Improved detection limits of protein optical fiber biosensors coated with gold nanoparticles

Lépinay, Sandrine; Staff, Alyssa; Ianoul, Anatoli; Albert, Jacques

doi:10.1016/j.bios.2013.08.058

Cited by 135 publications

(92 citation statements)

References 45 publications

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“…As for biosensing applications, different types of nanocoatings are deposited on the fiber as improved substrates for the implementation of the selective biolayer, such as titania-silica sol-gel-derived nm-thick films [19], thin film of atactic polystyrenes (PS) [30], graphene oxide (GO) films [31], composites of GO film and single-walled carbon nanotubes (SWNTs) [32], or gold nanoparticles [33] with the purpose of improving the performance of the sensor by leading to greater sensitivities and lower detection limits. Figure 3A details the flow chart of the manufacturing steps for coating a μm-thick EFBG with GO and SWNTs, whereas Figure 3B accounts for a SEM image of the proposed sensor.…”

Section: How Can Nanotechnology Meet Ofg-based Sensing Platforms?mentioning

confidence: 99%

“…Finally, a series of other BREs, based on biointeractions such as enzymatic processes [58,59], biotin/streptavidin affinity [18,33,[60][61][62], virus-specific recognition (bacteriophage T4/Escherichia coli bacteria) [63][64][65][66] and biomimetic affinity processes with molecularly imprinted polymers (MIPs) [67], have been implemented (Table 3). …”

Section: Applicationsmentioning

confidence: 99%

“…The biotin/streptavidin recognition experiments showed a LOD of 2 pm. TFBGs were also used by Lepinay et al [33], which functionalized the fiber surface with noble metal NPs either with gold nano-cages (AuNC) or gold nanospheres (AuNS). In this study, the immobilized BRE onto the NP was the avidin, while the analyte was biotin.…”

Section: Ofg-based Biosensing Based On Other Bresmentioning

confidence: 99%

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Biosensing with optical fiber gratings

et al. 2017

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Optical fiber gratings (OFGs), especially longperiod gratings (LPGs) and etched or tilted fiber Bragg gratings (FBGs), are playing an increasing role in the chemical and biochemical sensing based on the measurement of a surface refractive index (RI) change through a label-free configuration. In these devices, the electric field evanescent wave at the fiber/surrounding medium interface changes its optical properties (i.e. intensity and wavelength) as a result of the RI variation due to the interaction between a biological recognition layer deposited over the fiber and the analyte under investigation. The use of OFG-based technology platforms takes the advantages of optical fiber peculiarities, which are hardly offered by the other sensing systems, such as compactness, lightness, high compatibility with optoelectronic devices (both sources and detectors), and multiplexing and remote measurement capability as the signal is spectrally modulated. During the last decade, the growing request in practical applications pushed the technology behind the OFG-based sensors over its limits by means of the deposition of thin film overlays, nanocoatings, and nanostructures, in general. Here, we review efforts toward utilizing these nanomaterials as coatings for high-performance and low-detection limit devices. Moreover, we review the recent development in OFG-based biosensing and identify some of the key challenges for practical applications. While high-performance metrics are starting to be achieved experimentally, there are still open questions pertaining to an effective and reliable detection of small molecules, possibly up to single molecule, sensing in vivo and multi-target detection using OFG-based technology platforms.

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Section: How Can Nanotechnology Meet Ofg-based Sensing Platforms?mentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Ofg-based Biosensing Based On Other Bresmentioning

confidence: 99%

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Biosensing with optical fiber gratings

et al. 2017

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“…Metallic nanoparticles such as gold (Au) possess unique electronic and optical properties as well as chemical inertness and its ability for surface functionalisation which is due to the negative charge on its surface [112][113][114]. Gold's unique electronic and optical properties have resulted in its use in biosensors [115][116][117][118] and bioimaging [119][120][121][122][123] as well as photothermal therapy [121][122][123][124][125]. Gold's ease at functionalisation with organic molecules allows for conjugation with ligands, antibodies or drug molecules for active or passive drug delivery [126][127][128][129][130].…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

“…This review investigates other nanosystems such as metallic nanoparticles like gold (Au) [112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130] and silver (Ag) , bimetallic nanoparticles like iron cobalt (Fe-Co) [78][79][80][92][93][94][95][96][97]108,109] and iron platinum (Fe-Pt) [155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171][172] and metal oxides including titanium dioxide (TiO 2 ) [1...…”

Section: Introductionmentioning

confidence: 99%