Improved dissolution of ibuprofen after crystallization from polymeric solution: Correlation with crystal parameter

Abstract

The objective of the present work was to investigate the effect of various hydrophilic polymers like hydroxypropylmethyl cellulose, methyl cellulose, carboxymethyl cellulose and poly vinyl alcohol on the in vitro dissolution property of ibuprofen (IBU) crystallized from aqueous polymeric solutions. By using solvent-change technique, IBU crystal products were produced in presence of the selected polymers. Results showed that in presence of polymers; crystallization yield of IBU was higher than that of pure drug crystal (absence of polymer). SEM photographs revealed visible changes in the crystal morphology in the presence of polymers. The FTIR spectra of the crystallized IBU (polymer-treated) showed a shifting of the acid-dimer peak from 1718 cm-1 to 1721 cm-1 but absence of specific peaks for polymers. XRD study further confirmed absence of polymers in the crystallized IBU as no specific peaks were observed for the polymers. A higher percentage of cumulative drug release was reported for the polymeric-treated IBU crystals than that of plain IBU. Further in vivo studies are warranted to establish the in vitro-in vivo correlation for the future technology transfer of the formulation.

Aspirin-hydrogel ocular film for topical delivery and ophthalmic anti-inflammation

“…In vitro dissolution of aspirin of the films was carried out in the USP type II dissolution apparatus (Electolab, TDT06L, India) by utilizing 200 ml phosphate buffer (pH 6.8) as dissolution media at 34.0 ± 0.2 °C and 50 rpm for 6 h. 18,[31][32][33] A piece of film, weighing between 55-72 mg was cut and attached to the glass slide using cyanoacrylate glue and carefully placed it into the bottom of the vessel containing the dissolution medium. At different time intervals, 10 ml of the samples were withdrawn through a membrane filter (0.45 µm, syringe driven) and the same volume was replaced in each vessel with fresh medium.…”