Improved Drug Loading and Sustained Release of Entecavir‐loaded PLGA Microsphere Prepared by Spray Drying Technique

Kim, Dae Jung; Ho, Myoung Jin; Choi, Young Wook; Kang, Myung Joo

doi:10.1002/bkcs.11682

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…Recently, Kim et al ( 2019a , b ) described a formulation composed by bupivacaine-loaded PLGA MPs (BPC-PLGA-MPs) and fibrin glue (FG), to reduce and control postoperative pain. Currently, the patients affected by post-surgical pain are treated with long-term oral and/or patch treatments, which often cause systemic toxicity.…”

Section: Drug Encapsulation and In Vitro And In Vivo Releasementioning

confidence: 99%

“…Interestingly, only the animals treated with FG_BPC-PLGA-MPs but not with control formulations, showed an intense increase in paw withdrawal threshold (PWT) during the entire testing period (10 days) due to longer drug release. Considering that the actual approved formulation of bupivacaine is active for only 72 h, this approach could eliminate multiple daily injections of bupivacaine improving patient compliance (Kim et al 2019a , b ).…”

Section: Drug Encapsulation and In Vitro And In Vivo Releasementioning

confidence: 99%

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Recent advances in the formulation of PLGA microparticles for controlled drug delivery

et al. 2020

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Polymeric microparticles (MPs) are recognized as very popular carriers to increase the bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different kinds of polymers, poly-(lactic-co-glycolic acid) (PLGA) is one of the most accepted materials for this purpose, because of its biodegradability (due to the presence of ester linkages that are degraded by hydrolysis in aqueous environments) and safety (PLGA is a Food and Drug Administration (FDA)-approved compound). Moreover, its biodegradability depends on the number of glycolide units present in the structure, indeed, lower glycol content results in an increased degradation time and conversely a higher monomer unit number results in a decreased time. Due to this feature, it is possible to design and fabricate MPs with a programmable and time-controlled drug release. Many approaches and procedures can be used to prepare MPs. The chosen fabrication methodology influences size, stability, entrapment efficiency, and MPs release kinetics. For example, lipophilic drugs as chemotherapeutic agents (doxorubicin), anti-inflammatory non-steroidal (indomethacin), and nutraceuticals (curcumin) were successfully encapsulated in MPs prepared by single emulsion technique, while water-soluble compounds, such as aptamer, peptides and proteins, involved the use of double emulsion systems to provide a hydrophilic compartment and prevent molecular degradation. The purpose of this review is to provide an overview about the preparation and characterization of drug-loaded PLGA MPs obtained by single, double emulsion and microfluidic techniques, and their current applications in the pharmaceutical industry. Graphic abstract

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Section: Drug Encapsulation and In Vitro And In Vivo Releasementioning

confidence: 99%

Section: Drug Encapsulation and In Vitro And In Vivo Releasementioning

confidence: 99%

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

et al. 2020

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“…PLGA is an ideal carrier because of its stability, low toxicity, controllable biodegradation and good biocompatibility. 20 Therefore, the double emulsion solvent evaporation method 21 was used to prepare TB@PLGA NPs ( Figure S1 ) to prevent the aggregation of TB. Different volume ratios of the TB and PLGA solutions were investigated to optimize the preparation conditions.…”

Section: Resultsmentioning

confidence: 99%

TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation

Yang¹,

Tang²,

Liu³

et al. 2021

IJN

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Background: Phototherapy has significant potential as an effective treatment for cancer. However, the application of a multifunctional nanoplatform for photodynamic therapy (PDT) and photothermal therapy (PTT) at a single excitation wavelength remains a challenge. Materials and Methods: The double emulsion solvent evaporation method was used to prepare toluidine blue@poly lactic-co-glycolic acid (TB@PLGA) nanoparticles (NPs). The biocompatibility of TB@PLGA NPs was evaluated, and a 660 nm luminescence was used as the light source. The photothermal effect, photothermal stability, and singlet oxygen yield of NPs in an aqueous solution verified the feasibility of NPs as a PTT/PDT synergistic therapy drug. Results: TB@PLGA NPs were successfully prepared and characterized. In vitro experiments demonstrated that TB@PLGA NPs can cause massive necrosis of tumor cells and induce apoptosis through a photodynamic mechanism under 660 nm laser irradiation. The TB@PLGA NPs also achieved optimal tumor inhibition effect in vivo. Conclusion:The TB@PLGA NPs prepared in this study were applied as a dual-mode phototherapeutic agent under single laser irradiation. Both in vitro and in vivo experiments demonstrated the good potential of PTT/PDT for tumor inhibitors.

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“…Therefore, polylactic acid‐glycolic acid (PLGA) has widespread applications as a drug carrier in tissue engineering 36 . The PLGA microsphere size and release profile can be flexibly regulated by the lactide/glycolide ratio and the polymer molecular weight 37,38 . Our previous study involved much effort to enrich BMP‐2 plasmid with polyethylenimine (PEI) and encapsulate it with PLGA microspheres to achieve the sustained release of pBMP‐2/PEI nanoparticles and it was finally confirmed to have a good osteogenesis potential through in vitro and in vivo experiments 39…”

Section: Introductionmentioning

confidence: 99%

Construction of a BMP‐2 gene delivery system for polyetheretherketone bone implant material and its effect on bone formation in vitro

Qin

Gan

et al. 2022

J Biomed Mater Res

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Polyetheretherketone (PEEK) has been widely investigated for improving its biological inert to enable it to achieve stronger osteogenic capability and to be a promising material in implant fields. The most important mechanism that makes a successful implantation is osteointegration. Surface modification is an appropriate method to maintain the excellent mechanical properties of PEEK and simultaneously endow PEEK certain biological characters. In this work, we attempted to shape the nanotopography of PEEK surface by nitrogen low-temperature plasma and polydopamine coating on the surface as a secondary reaction platform to bond the aminated poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating the BMP-2 gene for enhancing the biological activity. Scanning electron microscope, atomic force microscopy, X-ray photoelectron spectroscopy and water contact angle (CA) measurements were applied to characterize the surface of modified or untreated PEEK. Surface characterization showed that the modification was successfully performed on PEEK including a rougher and more hydrophilic surface with nanotopographic features. The influence on cell adhesion, proliferation and differentiation was evaluated by culturing of rat bone marrow mesenchymal stem cells on different modified PEEK substrates in vitro. The biological results indicated that the low-temperature plasma treatment and PDA-coating on PEEK significantly promoted cell adhesion and proliferation. And the osteogenic differentiation was effectively improved by BMP-2 gene releasing from PLGA-NH 2 microspheres. The results showed that this novel biological surface modification endowed PEEK with outstanding bioactivity and osteogenic ability, providing a theoretical basis for application in the field of implantation. K E Y W O R D S biomaterial, improved cell adhesion, PLGA-NH 2 microspheres, promoted osteogenic differentiation 1 | INTRODUCTION For repairing bone defects resulting from surgery, trauma, diseases, and congenital malformations, titanium-based alloys have become the Shuang Qin and Zhengkuan Lu contributed equally to this work

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Improved Drug Loading and Sustained Release of Entecavir‐loaded PLGA Microsphere Prepared by Spray Drying Technique

Cited by 11 publications

References 31 publications

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation

Construction of a BMP‐2 gene delivery system for polyetheretherketone bone implant material and its effect on bone formation in vitro

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