Improved in vitro antioxidant properties and hepatoprotective effects of a fermented Inula britannica extract on ethanol-damaged HepG2 cells

Inula britannica Inhibits Adipogenesis of 3T3-L1 Preadipocytes via Modulation of Mitotic Clonal Expansion Involving ERK 1/2 and Akt Signaling Pathways

“…In response to increasing awareness of personal health, dietary polyphenols are garnering interest in the prevention and improvement of various disorders as an alternative medicine based on their biological functionalities [ 19 ]. Nutritional, clinical, and epidemiological studies have supported the evidence that appropriate dosage of dietary phenolic compounds improves human health by decreasing the risk and preventing the development of degenerative disorders with reduced adverse effects [ 20 , 21 ].…”

“…Nutritional, clinical, and epidemiological studies have supported the evidence that appropriate dosage of dietary phenolic compounds improves human health by decreasing the risk and preventing the development of degenerative disorders with reduced adverse effects [ 20 , 21 ]. Medicinal herbs are an abundant source of diverse dietary polyphenols exhibiting prophylactic properties and therapeutic efficacy in various diseases including inflammatory- and obesity-associated disorders [ 19 , 22 ]. Inula britannica is a flowering wild plant distributed in eastern Asia and is used for medicinal purposes based on traditional applications.…”

“…Inula britannica is a flowering wild plant distributed in eastern Asia and is used for medicinal purposes based on traditional applications. The flower of I. britannica exhibits neuroprotective, antimicrobial, anti-tumor, and anti-inflammatory properties [ 19 , 23 , 24 ], which are potentially attributable to its bio-active compounds such as flavonoids, sesquiterpene lactones, and polysaccharides [ 25 , 26 , 27 , 28 ]. For example, polysaccharides derived from the flower of I. britannica demonstrated hypoglycemic and anti-hyperlipidemic properties in an alloxan-induced diabetic mouse model [ 29 ].…”

Integrated Pharmaco-Bioinformatics Approaches and Experimental Verification To Explore the Effect of Britanin on Nonalcoholic Fatty Liver Disease

“…Recently, growing interest in Oriental medicine has prompted a surge in research on natural compounds that exhibit potential for treating inflammatory diseases. Inula japonica Thunb, a frequently utilized medicinal plant in traditional Chinese medicine, has gained recognition for its ability to regulate spleen, liver, lung, and stomach function, as well as its potential in preventing abortion. , Britanin (Bri) is a bioactive sesquiterpene lactone mainly found in plants like Inula britannica, Inula japonica, and Inula lineariifolia Turcz., and it belongs to the category of pharmacologically active phytochemicals. , Inula britannica extract has shown antioxidant and hepatoprotective properties in vitro . Moreover, Wu et al reported that Britanin functions as a protective phytochemical against ischemic brain injury in a rat model of middle cerebral artery occlusion-reperfusion (MCAO/R) .…”

“… 17 , 18 Inula britannica extract has shown antioxidant and hepatoprotective properties in vitro. 19 Moreover, Wu et al reported that Britanin functions as a protective phytochemical against ischemic brain injury in a rat model of middle cerebral artery occlusion-reperfusion (MCAO/R). 20 Kim et al demonstrated that Britanin mitigates airway inflammation induced by ovalbumin in a murine model of asthma.…”