As a new type of jamming, the interrupted sampling repeater jamming (ISRJ) derived from the digital radio frequency memory (DRFM) technology, can generate coherent multiple false targets after pulse compression. At present, the traditional interference suppression method and its improved methods have insufficient characteristics and poor detection performance under the condition of low signal-to-noise ratio (SNR). Aiming at addressing this defect, this paper proposes an interference suppression method for ISRJ based on singular spectrum entropy function (SSEF) from the aspects of singular value decomposition (SVD) and information entropy theories. In this method, firstly, considering the local fine characteristics and extraction efficiency, an adaptive multi-scale segmentation (AMS) method is proposed. The purpose of this processing is to extend the salient characteristics while to smooth the similar ones. In AMS, the segmentation criterion based on average energy of segments and the constraint of minimum segmentation is also proposed, then the improved delay embedded matrix is established from the improved trajectory matrix by AMS and delay embedded mapping. Secondly, the singular spectrum of the improved delay embedded matrix is extracted by SVD. Thirdly, because the recognition algorithms based on singular spectrum analysis (SSA), classical SSE and other characteristics fail at low SNR, this paper proposes a characteristic named as SSEF retrieved from the Shannon entropy model. The following proposed entropy-based threshold detection is carried out on the echo signal to realize the band-pass filtering and interference suppression. Finally, experiment results show that in comparison with other interference suppression approaches, SSEF can increase the probability of target detection and the peak-to-side-lobe ratio (PSR) after pulse compression, which validates its stability to noise and jamming especially in the condition of low SNRs.