Improved liquid–liquid extraction by modified magnetic nanoparticles for the detection of eight drugs in human blood by HPLC-MS

Yang, Feifei; Ma, Ke; Cao, Yu; Ni, Chunfang

doi:10.1039/d1ra01530c

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Functionalized MNPs could be used for drug detection in various biological fluids. Yang et al developed a TiO 2 -modified mesoporous magnetite nanoparticle for the detection of commonly used drugs in human blood [ 104 ] using a liquid–liquid extraction procedure. The authors concluded that the proposed procedure using modified magnetic nanoparticles has some advantages, among them being the minimization of blood matrix effects during analysis.…”

Section: Diagnostic Application Of Mnpsmentioning

confidence: 99%

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

et al. 2023

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In the last few decades, point-of-care (POC) sensors have become increasingly important in the detection of various targets for the early diagnostics and treatment of diseases. Diverse nanomaterials are used as building blocks for the development of smart biosensors and magnetite nanoparticles (MNPs) are among them. The intrinsic properties of MNPs, such as their large surface area, chemical stability, ease of functionalization, high saturation magnetization, and more, mean they have great potential for use in biosensors. Moreover, the unique characteristics of MNPs, such as their response to external magnetic fields, allow them to be easily manipulated (concentrated and redispersed) in fluidic media. As they are functionalized with biomolecules, MNPs bear high sensitivity and selectivity towards the detection of target biomolecules, which means they are advantageous in biosensor development and lead to a more sensitive, rapid, and accurate identification and quantification of target analytes. Due to the abovementioned properties of functionalized MNPs and their unique magnetic characteristics, they could be employed in the creation of new POC devices, molecular logic gates, and new biomolecular-based biocomputing interfaces, which would build on new ideas and principles. The current review outlines the synthesis, surface coverage, and functionalization of MNPs, as well as recent advancements in magnetite-based biosensors for POC diagnostics and some perspectives in molecular logic, and it also contains some of our own results regarding the topic, which include synthetic MNPs, their application for sample preparation, and the design of fluorescent-based molecular logic gates.

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Section: Diagnostic Application Of Mnpsmentioning

confidence: 99%

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

et al. 2023

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“…Yang et al (2021) used magnetic‐modified nanoparticles for the detection of eight drugs in human blood, obtaining recovery rates of 79.5%–99.9% and LOQs of 0.14–1.03 ng/mL (Yang et al, 2021). Polypyrrole/magnetic nanoparticles composite was evaluated as a sorbent for dispersive micro‐solid‐phase extraction of antidepressant drugs from biological fluids in the work of Asgharinezhad et al (2015).…”

Section: Green Sorbentsmentioning

confidence: 99%

“…This technique prevents the formation of agglomerates that may reduce the surface area, thus the adsorption capacity (Agarwal et al, 2019;Ghaemi et al, 2015;Jadhav et al, 2019;Weldegebrieal, 2020). Yang et al (2021) used magnetic-modified nanoparticles for the detection of eight drugs in human blood, obtaining recovery rates of 79.5%-99.9% and LOQs of 0.14-1.03 ng/mL (Yang et al, 2021). Polypyrrole/magnetic nanoparticles composite was evaluated as a sorbent for dispersive micro-solid-phase extraction of antidepressant drugs from biological fluids in the work of Asgharinezhad et al (2015).…”

Section: Nanoparticlesmentioning

confidence: 99%

Green chemistry: Developments and perspectives for sample treatment in forensic methodologies

Birk

Santos

Schwarz

et al. 2023

WIREs Forensic Science

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In recent years, the environmental implications of advancements in various scientific fields, including analytical chemistry, have become a subject of increasing concern. As a result, the concept of “Green Analytical Chemistry” has been developed, comprising a set of practices designed to reduce the use of toxic chemicals. In the field of analytical, minimizing chemical usage presents a significant challenge, as several sample preparation methods inherently require the utilization of large quantities of solvents. However, this challenge can be addressed through the implementation of both single and combined strategies. One of these strategies is the miniaturization of methods applying the principles of classic liquid–liquid and solid phase extractions in a smaller scale of reagents and samples. In addition, the conventional reagents used in sample preparation can be replaced with green solvents and sorbents. The utilization of miniaturized techniques in forensic toxicology has been widely adopted. Despite this, there remain numerous unexplored applications due to the vast diversity of analytes and biological matrices available. Therefore, implementing green chemistry practices can provide numerous benefits, including enhanced worker safety, reduced waste, and cost savings.This article is categorized under: Toxicology > Analytical Toxicology > Drug Analysis Toxicology > Post‐Mortem

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“…Therefore, in recent years, several attempts were made to replace the mentioned routine methods with new and efficient approaches [5]. Up to now, different sample preparation methods like dispersive liquid-liquid microextraction [6], liquid-phase microextraction [7], solid-phase extraction [8,9], solid-phase microextraction [10], magnetic solid-phase extraction [11], liquid-liquid extraction [12,13], and dispersive solid-phase extraction (DSPE) [14,15] were used as the sample preparation methods before drug analysis. Among the mentioned methods, DSPE has some features such as simplicity, easiness, and inexpensiveness.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the use of nanomaterials as the sorbents in DSPE has been widely investigated due to their unique physical and chemical properties including high thermal resistance, high surface area, and good mechanical strength [11]. Furthermore, the use of magnetic nanomaterials that are collected by an external magnet without the need for centrifugation reduces adsorption and desorption times [13]. Different magnetic nanoparticles were prepared based on carbonnanotubes [16], graphene [17], graphene oxide [18,19], silica [20], metal organic frameworks (MOFs), etc.…”

Section: Introductionmentioning

confidence: 99%

Selective extraction of apixaban from plasma by dispersive solid‐phase microextraction using magnetic metal organic framework combined with molecularly imprinted polymer nanocomposite

Fathi

Mogaddam

Sorouraddin

et al. 2023

J of Separation Science

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This research aims to synthesize a specific and efficient sorbent to use in the extraction of apixaban from human plasma samples and its determination by high‐performance liquid chromatography‐tandem mass spectrometry. High specific surface area of metal‐organic framework, magnetic property of iron oxide nanoparticles, selectively of molecular imprinted polymer toward the analyte, and the combination of dispersive solid‐phase extraction method with a sensitive analysis system provided an efficient analytical method. In this study, first, a molecularly imprinted polymer combined with magnetic metal organic framework nanocomposite was prepared and then characterized using different techniques. Then the sorbent particles were used for selective extraction of the analyte from plasma samples. The efficiency of the method was improved by optimizing effective parameters. According to the validation results, wide linear range (1.02–200 ng mL−1), acceptable coefficient of determination (0.9938), low limit of detection (0.32 ng mL−1) and limit of quantification (1.02 ng mL−1), high extraction recovery (78%), and good precision (relative standard deviations ≤ 2.9% for intra‐ (n = 6) and interday (n = 6) precisions) were obtainable using the proposed method. These outcomes showed the high potential of the proposed method for screening apixaban in the human plasma samples.

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Improved liquid–liquid extraction by modified magnetic nanoparticles for the detection of eight drugs in human blood by HPLC-MS

Abstract: High-performance magnetic Fe3O4@TiO2, nanospheres with mesoporous structures was synthesized for cleanup phosphatidic acid and fatty acids in blood sample for 8 drugs test with HPLC-MS.

Cited by 5 publications

References 29 publications

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

Green chemistry: Developments and perspectives for sample treatment in forensic methodologies

Selective extraction of apixaban from plasma by dispersive solid‐phase microextraction using magnetic metal organic framework combined with molecularly imprinted polymer nanocomposite

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