Improved metabolism and body composition beyond normal levels following gastric bypass surgery: a longitudinal study

Abstract

Subjects who underwent RYGB and reached a postobese state demonstrated a beneficial body composition, slightly increased insulin sensitivity as indirectly measured by HOMA-IR and higher insulin clearance, lower atherogenic lipid/lipoprotein levels and benign adipocyte morphology compared with control subjects who had never been obese. In line with previous results, our findings may in part explain why RYGB confers long-term protection against metabolic complications.

Body fat mass and distribution as predictors of metabolic outcome and weight loss after Roux-en-Y gastric bypass

“…Our findings concerning supra-normality metabolic and WAT findings after RYGB have been validated in an additional study including a matched control group. In this study, patients were matched two years after RYGB and insulin sensitivity was also measured by clamp 175 . This study confirmed higher HOMA-IR and more hyperplastic adipose tissue in the postobese state, although clamp values did not differ significantly between groups.…”

Long‐term changes in adipose tissue gene expression following bariatric surgery

“…All these factors may contribute to increasing the risk of T2D [6]. We have previously shown that in obese subjects undergoing Roux‐en‐Y gastric bypass (RYGB) surgery, WAT function is improved 2 years postsurgery and further improved at a 5‐year follow‐up despite significant weight regain [7,8]. However, the mechanisms underlying these long‐term improvements in WAT phenotype remain unclear.…”

Metabolic Impact of Body Fat Percentage Independent of Body Mass Index in Women with Obesity Remission After Gastric Bypass

“…Weight loss induces favorable changes including improvement of metabolic parameters and adipose tissue function. Following RYGB, these improvements have been reported not only to be a normalization, but rather to reach "supranormal" levels [15,16]. Weight loss-independent metabolic improvements are seen after RYGB, mediated by factors such as gut hormones and bile acids [17].…”