Improved method for determination of sulfonamides in milk and tissues

Tishler, Frederick; Sutter, Juli; Bathish, J. N.; Hagman, Herbert E.

doi:10.1021/jf60155a003

Cited by 44 publications

(22 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To separate the sulfa drug from biological components and from other drugs in the sample which react with the B.M. reagent, a clean up procedure with a solvent system (Fellig and Westheimer, 1968;Tishler et al, 1968) or thin layer chromatography (Phillips, 1975) were reported. By this method, a large amount of specimens was needed to detect the 0.1 p.p.m.…”

Section: ) Clearance In Eggsmentioning

confidence: 99%

Clearance of Sulfamethoxazole in Eggs and Tissues of Chickens

1977

View full text Add to dashboard Cite

Clearance of sulfamethoxazole (SMX, or sulfisomezole) in eggs and tissues of chicken after withdrawal of the drug which was medicated feed additively (at 0.2 or 0.4%) or administered intramuscularly (100 mg./kg., twice daily) for 5 successive days was determined using a fluorescamine reagent. Clearance patterns of SMX were found to be different between albumen and yolk. SMX level in albumen diminished linearly to below 0.1 p.p.m. (sensitivity level) by 5 days after the cessation of medication. On the other hand, SMX level in yolk remained at a plateau until 4 days, and thereafter decreased linearly to below 0.1 p.p.m. by 10 days. SMX levels in most tissues diminished below 0.1 p.p.m. by 3 days and those in kidney and skin by 4 days. Clearance patterns in tissue were quite similar to those in egg albumen. Proportion of acetylated-SMX to total-one in both albumen and yolk tended to increase up to 10% with the lapse of time after drug withdrawal. Acetylation was high in liver (36.5-43.6%), spleen skin and fat, but low in breast muscle and kidney (3.7-11%) in the groups of feed addition; while acetylation was low in liver of the group of intramuscular injection.

show abstract

Section: ) Clearance In Eggsmentioning

confidence: 99%

Clearance of Sulfamethoxazole in Eggs and Tissues of Chickens

1977

View full text Add to dashboard Cite

show abstract

“…Several publications (3,(5)(6)(7) reported the recoveries of sulfonamides utilizing the colorimetric assays, and all reported values of 7546%. Only Houston and Umstead (7) reported on sulfamethazine, and these results were a combination of sulfamethazine-sulfathiazole residues in milk.…”

Section: Discussionmentioning

confidence: 99%

High-Pressure Liquid Chromatographic Determination of Sulfamethazine Residue in Bovine Tissue

Johnson

Jeter

Claiborne

1975

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…The use of medicated feed additives is controlled by the Food and Drug Administration (FDA). Other feed additives such as larvacides are controlled by the Environmental Protection Agency (EPA) since they are not absorbed and have no direct physiological impact on the animal (Tishler et al, 1990).…”

Section: Major Drugs Used In Beef Cattlementioning

confidence: 99%

“…Sulfonamides are generally used to treat a wide variety of bacterial and coccidial infections in food producing animals especially, in poultry and are used as growth promoters in swine. Consequently, drug manufacturers were not required to submit data on tissues residues following their use in food producing animals (Tishler et al, 1990).…”

Section: Drug Residues In Meatmentioning

confidence: 99%

Drug Residues in Foods of Animal Origin and Their Impact on Human Health: Review

2021

FSQM

View full text Add to dashboard Cite

The safety of human food is threatened by various agents including pathogenic microorganisms, and antimicrobial agents. Antibiotics are natural products of a micro-organism, or similar semi-synthetic products that inhibit the growth or destroy microorganisms. Residues of veterinary medicines are defined as pharmacologically active substances, principles, or degradation products and their metabolites, which remain in foodstuffs obtained from animals that have been administered the veterinary medicine. The most common causes for the presence of antibiotic residues in food of animal origin are violation of withdrawal periods, overdosing of antibiotics and use of inaccurate routes of administration of drugs. Drug residues concentrations vary from tissue to tissue and are generally observed to be higher in tissues of storage such as body fat or in organs that actively metabolize and excrete them. Probably the most common way milk is contaminated by penicillin is through intra-mammary infusion of the drug in the treatment of mastitis. The presence of antibiotics or their metabolites in food is potentially hazardous to health as it may cause allergic reactions in people and antibiotic resistance in pathogenic microorganisms. Some antibiotics like streptomycin, neomycin and gentamicin has been reported to cause damage to the kidney and to hearing. Allergic reaction to the human body mostly resulted from β-Lactam antibiotics. Anaphylactic reactions are reported to result from consumption of beef or pork containing penicillin. Drugs in which their residues induce cancer in humans or consumers are: nitrofurans, nitroimdazoles, etc. Antibiotics are invariably administered to dairy cattle, but their indiscriminate use, without adequate technical and veterinary control, can lead to a series of negative consequences at all levels of the dairy productive chain. Many antibacterial and anticoccidial drugs are licensed for use in poultry for treatment of enteric and respiratory disease. Potential adverse effects of drugs that appear as residues in food animals are: carcinogenic, allergic, toxic, neurologic disorder and microbiological effects.

show abstract

Improved method for determination of sulfonamides in milk and tissues

Cited by 44 publications

References 2 publications

Clearance of Sulfamethoxazole in Eggs and Tissues of Chickens

Clearance of Sulfamethoxazole in Eggs and Tissues of Chickens

High-Pressure Liquid Chromatographic Determination of Sulfamethazine Residue in Bovine Tissue

Drug Residues in Foods of Animal Origin and Their Impact on Human Health: Review

Contact Info

Product

Resources

About