Improved methodologies for synthesis of prenylated xanthones by microwave irradiation and combination of heterogeneous catalysis (K10 clay) with microwave irradiation

Structural modifications of coumarin derivatives: Determination of antioxidant and lipoxygenase (LOX) inhibitory activity

“…Therefore, in order to further examine the bioactivity of the prenyloxy analogues, we synthesised three new coumarin derivatives, compounds 8, 9 and 10, through the alkylation of the appropriate coumarin by prenyl bromide. 23 The general method for the synthesis of these prenyloxy coumarins is outlined in Scheme 3.…”

1-Hydroxy-3-(3-methylbut-2-enyloxy)xanthone

“…We have looked for an alternative method to obtain prenylated xanthones. The title compound was the first example of a prenylated xanthone synthesized by the microwave irradiation method (Castanheiro et al, 2009). In fact, microwave-assisted heating under controlled conditions is an invaluable technology for medicinal chemistry because it often dramatically reduces reaction times.…”

“…For background literature and synthesis of prenylated xanthones, see: Pinto et al (2005); Epifano et al (2007); Castanheiro et al (2007). For the synthesis of the title compound using microwave radiation, see: Castanheiro et al (2009). For analysis of related structures of xanthone derivatives, see: Gales et al (2001Gales et al ( , 2005a; Castanheiro et al (2007).…”

New chiral stationary phases based on xanthone derivatives for liquid chromatography

“…Xanthone derivatives comprise an important class of oxygenated heterocycles, many of which possess a broad spectrum of biological/pharmacological activities . In recent years, the synthesis of new bioactive xanthone derivatives using different synthetic methodologies, including chiral derivatives of xanthones (CDXs), has been an area of great interest in our group …”

“…[19][20][21][22][23] In recent years, the synthesis of new bioactive xanthone derivatives using different synthetic methodologies, including chiral derivatives of xanthones (CDXs), 24,25 has been an area of great interest in our group. [26][27][28][29] The CDXs, when anchored to a chromatographic support by covalent linkage through a spacer, possess all the necessary attributes to constitute chromatographic selectors. 30 The 3D quasi-planar structure and peculiar electronic properties of the xanthone scaffold, 31 associated with a diversity of functional groups and chiral moieties, constitute structural characteristics affording the establishment of different types of interactions, as well as contributing threedimensionality factors that influence the enantioselectivity.…”