2023
DOI: 10.1016/j.jpeds.2023.113483
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Improved Neurodevelopmental Outcomes at 5.5 Years of Age in Children Who Received Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula Through 12 Months: A Randomized Controlled Trial

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Cited by 17 publications
(7 citation statements)
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“…For instance, in a randomized controlled trial (RCT), infants fed an experimental low-energy, low-protein formula supplemented with bovine MFGM until 6 months of age demonstrated several positive outcomes, including improved performance in the cognitive domain of the Bayley Scales of Infant and Toddler Development 3rd Edition at 12 months of age [ 84 ]. Similarly, children who received MFGM-supplemented infant formula until 12 months of age exhibited enhanced cognitive outcomes in multiple domains at 5.5 years of age, including measures of intelligence and executive function [ 56 ]. Studies indicated that supplementation of formula with bovine MFGM can help bridge the cognitive development gap between breastfed infants and formula-fed infants [ 55 , 85 , 86 , 87 ].…”
Section: Interfacial Properties Of Mfgm and Its Applications In Food ...mentioning
confidence: 99%
“…For instance, in a randomized controlled trial (RCT), infants fed an experimental low-energy, low-protein formula supplemented with bovine MFGM until 6 months of age demonstrated several positive outcomes, including improved performance in the cognitive domain of the Bayley Scales of Infant and Toddler Development 3rd Edition at 12 months of age [ 84 ]. Similarly, children who received MFGM-supplemented infant formula until 12 months of age exhibited enhanced cognitive outcomes in multiple domains at 5.5 years of age, including measures of intelligence and executive function [ 56 ]. Studies indicated that supplementation of formula with bovine MFGM can help bridge the cognitive development gap between breastfed infants and formula-fed infants [ 55 , 85 , 86 , 87 ].…”
Section: Interfacial Properties Of Mfgm and Its Applications In Food ...mentioning
confidence: 99%
“…In term infants, HMO exposure is positively associated with cognitive, language, and motor skill domains between 18 and 24 months of age, however, this effect was not seen in preterm infants [ 41 ]. A recent RCT showed improved cognitive function at 5.5 years of age in MFGM-supplemented term infants receiving formula milk [ 42 ]. However, another RCT comparing human donor milk to formula feeding in preterm infants unable to receive sufficient mothers’ milk did not show differences in neurocognitive outcome at 2 years of age [ 43 ].…”
Section: Modulating Gut Microbiota For Neurodevelopmentmentioning
confidence: 99%
“…Frontiers in Pharmacology frontiersin.org characteristics, LF has been incorporated into infant formula (Colombo et al, 2023) and utilized in adjunct anti-infective treatment (Jiang et al, 2014).…”
Section: Definitions Biological Functions and Areas Of Applicationmentioning
confidence: 99%