Improved operation of simulated moving bed processes through cyclic modulation of feed flow and feed concentration

Schramm, H.; Kienle, Achim; Kaspereit, Malte; Seidel‐Morgenstern, A.

doi:10.1016/j.ces.2003.08.015

Cited by 78 publications

(44 citation statements)

References 21 publications

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“…Another improved SMB process using a dynamic parameter variation is the "ModiCon" concept [31,[33][34][35][36]. This approach is characterized by variation of the feed concentration during each switching interval, which can be achieved, for example, by using a gradient mixing device at the feed port together with two reservoirs, one containing a higher concentrated and the other a lower concentrated feed mixture.…”

Section: A2 Modulation Of Feed Concentrations (Modicon)mentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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Chromatographic separation processes are widely used to isolate and purify value added products. Most frequently, such separation processes are performed exploiting the principles of injecting samples of the feed mixture in a repetitive periodic manner and collecting the target products batchwise. In the early 1960s, an alternative operation principle based on using several columns connected in series and exploiting a continuous countercurrent movement between the mobile and stationary phases initiated significant improvements in performing specific separation processes in the petrochemical and sugar industries. In the last decade, the so-called simulated moving bed (SMB) chromatography has rapidly entered the pharmaceutical industry. In particular enantioseparations using chiral stationary phases have become a strong driving force to develop more sophisticated concepts of continuous chromatography. Currently, the growing interest in efficient methods for the downstream processing of biomolecules enhances interest in SMB processes. This paper gives a brief overview of the new suggestions and trends. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [accessed July 4, 2008

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Section: A2 Modulation Of Feed Concentrations (Modicon)mentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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“…Until now, several strategies for enhancing the SMB performance have been reported in the literature [8][9][10][11][12][13][14][15][16][17]. Among them, the partial-discard strategy [15] was known to be highly effective in improving product purity in a four-zone SMB for binary separation.…”

Section: Introductionmentioning

confidence: 99%

Partial port-closing strategy for obtaining high throughput or high purities in a four-zone simulated moving bed chromatography for binary separation

Mun

2010

Journal of Chromatography A

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“…Therefore, preparative chromatographic resolution of racemates is being used increasingly in the pharmaceutical industry for rapidly accessing enantiomerically pure materials. [1][2][3][4][5] Most frequently used modes of preparative chromatography for chiral resolution include simulated moving bed (SMB), steady-state recycling (SSR), batch high performance liquid chromatography (HPLC), and supercritical fluid chromatography (SFC). SMB is a continuous process and almost always requires less solvent to separate a given quantity of racemate.…”

Section: Introductionmentioning

confidence: 99%

The application of preparative batch HPLC, supercritical fluid chromatography, steady‐state recycling, and simulated moving bed for the resolution of a racemic pharmaceutical intermediate

Yan¹,

Orihuela²,

Swanson³

2007

Chirality

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This article discusses the chromatographic resolution of a racemic pharmaceutical intermediate. Preparative batch high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC), steady-state recycling (SSR), and simulated moving bed (SMB) were used to resolve a total of 12.2 kg of a racemic pharmaceutical intermediate. In this study, a first batch of 0.8 kg of racemate was separated on the preparative batch HPLC and SFC, and subsequently another 5.9 kg of racemate was separated on the SSR. Lastly, a third batch of 5.5 kg was separated on the SMB. The separation conditions and results of these techniques are discussed. The productivities and solvent costs of SFC versus HPLC are compared. The productivities and solvent costs of SMB, SSR, and HPLC are also compared. The analytical method development and process optimization of these processes are also discussed in this article.

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Improved operation of simulated moving bed processes through cyclic modulation of feed flow and feed concentration

Cited by 78 publications

References 21 publications

New Developments in Simulated Moving Bed Chromatography

New Developments in Simulated Moving Bed Chromatography

Partial port-closing strategy for obtaining high throughput or high purities in a four-zone simulated moving bed chromatography for binary separation

The application of preparative batch HPLC, supercritical fluid chromatography, steady‐state recycling, and simulated moving bed for the resolution of a racemic pharmaceutical intermediate

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