Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma

Liu, C L; Fan, Sheung‐Tat; Lo, Chung Mau; Tso, WK; Lam, Chi‐Ming; Wong, John

doi:10.1002/bjs.5482

Cited by 73 publications

(44 citation statements)

References 26 publications

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“…Japanese high volume centers in which combined caudate lobe resection is routinely performed report relatively high curative resection rate (59-87%) and 5 year survival rate (33-44%) [74,87,124,127,[142][143][144][145][146][147][148]. Several reports from other countries also showed the benefits of this procedure for hilar/upper bile duct carcinoma [149][150][151][152][153][154]. These results indicate that combined caudate lobe resection should be performed in most cases of hilar or upper bile duct carcinoma for increasing curative resection rate and better prognosis.…”

Section: Cq16: What Are Considered As Unresectable Factors In Biliarymentioning

confidence: 85%

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Miyazaki

Yoshitomi

Miyakawa³

et al. 2015

J Hepato Biliary Pancreat

237

165

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Background The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for the management of biliary tract and ampullary carcinomas in 2008. Novel treatment modalities and handling of clinical issues have been proposed after the publication. New approaches for editing clinical guidelines, such as the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, also have been introduced for better and clearer grading of recommendations. Methods Clinical questions (CQs) were proposed in seven topics. Recommendation, grade of recommendation and statement for each CQ were discussed and finalized by evidencebased approach. Recommendation was graded to grade 1 (strong) and 2 (weak) according to the concept of GRADE system. Results The 29 CQs covered seven topics: (1) prophylactic treatment, (2) diagnosis, (3) biliary drainage, (4) surgical treatment, (5) chemotherapy, (6) radiation therapy, and (7) pathology. In 27 CQs, 19 recommendations were rated strong and 11 recommendations weak. Each CQ included the statement of how the recommendation was graded. Conclusions This guideline provides recommendation for important clinical aspects based on evidence. Future collaboration with cancer registry will be a key for assessment of the guidelines and establishment of new evidence. Free full-text articles and a mobile application of this guideline are available via

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Section: Cq16: What Are Considered As Unresectable Factors In Biliarymentioning

confidence: 85%

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Miyazaki

Yoshitomi

Miyakawa³

et al. 2015

J Hepato Biliary Pancreat

237

165

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“…Major hepatectomy with systematic nodal dissection is associated with a good chance of prolonged survival in patients with carcinoma involving the hepatic hilus, including those with advanced disease [47,48] . Extended hemihepatectomy, with or without pancreatoduodenectomy, plus extrahepatic bile duct resection and regional lymphadenectomy has recently been recognized as the standard curative treatment for hilar bile duct cancer.…”

Section: Operationmentioning

confidence: 99%

Diagnosis and initial management of cholangiocarcinoma with obstructive jaundice

Tajiri¹,

Yoshida²,

Mamada³

et al. 2008

WJG

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“…In a recent publication by Liu et al [42], a group of 142 patients is described with hilar cholangiocarcinoma in the period 1989–2004. For comparison of outcome, patients were divided between two groups: period 1, 1989–1998, and period 2, 1999–2004.…”

Section: Effects Of Blood Loss and Blood Transfusion In Cholangiocarcmentioning

confidence: 99%

Impact of Blood Loss on Outcome after Liver Resection

Boer¹,

Molenaar²,

Porte³

2007

Dig Surg

139

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Partial liver resections are the treatment of choice for patients with a malignant liver or bile duct tumor. The most frequent indications for partial liver resections are colorectal metastasis, hepatocellular carcinoma (HCC) and cholangiocarcinoma. Liver resection is the only therapy with a chance for cure in these patients. Refinements in surgical technique and increasing experience have contributed to a reduction in perioperative morbidity and mortality in recent years. Despite these improvements, partial liver resections remain a major surgical procedure and carry the risk for excessive blood loss and a subsequent need for blood transfusion. Blood transfusions have been associated with systemic side effects, such as depression of the immune system. Several studies have suggested that perioperative blood loss or transfusions have a negative impact on postoperative outcome. However, it has been debated whether this is due to a real cause-effect relationship or merely the result of more complicated surgery. We have reviewed the literature concerning studies focusing on the relationship between blood loss and blood transfusion during liver surgery for malignant tumors and postoperative outcome. Most studies were based on a retrospective analysis of single center experiences, using uni- and multivariate statistical methods. Most studies have demonstrated a significant and clinically relevant association between blood transfusion and postoperative mortality and morbidity, especially postoperative infectious complications. The effect of blood transfusions on tumor recurrence and more long-term mortality is much less clear and evidence varies depending on the type of malignancy. The strongest indication that blood transfusion may have an impact on tumor recurrence has been found for patients with early stages of HCC. However, overall, no such effect could be demonstrated for patients undergoing partial liver resection for late stages of HCC, colorectal liver metastasis or cholangiocarcinoma.

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Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma

Abstract: An aggressive surgical approach was associated with improved operative and survival outcomes for patients with hilar cholangiocarcinoma.

Cited by 73 publications

References 26 publications

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Diagnosis and initial management of cholangiocarcinoma with obstructive jaundice

Impact of Blood Loss on Outcome after Liver Resection

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Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma

Abstract: An aggressive surgical approach was associated with improved operative and survival outcomes for patients with hilar cholangiocarcinoma.

Cited by 73 publications

References 26 publications

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition

Diagnosis and initial management of cholangiocarcinoma with obstructive jaundice

Impact of Blood Loss on Outcome after Liver Resection

Contact Info

Product

Resources

About

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition