Improved osteogenesis and angiogenesis of theranostic ions doped calcium phosphates (CaPs) by a simple surface treatment process: A state-of-the-art study

Kermani, Farzad; Mollazadeh, Sahar; Kargozar, Saeid; Khakhi, J. Vahdati

doi:10.1016/j.msec.2021.112082

Cited by 23 publications

(11 citation statements)

References 47 publications

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“…4 displays the FTIR spectra of the synthesized MBGs before and after immersion in SBF. The marked bands in the range of 553–680 cm −1 and the broadband around 1100 cm −1 are related to P-O bonds [29] . The bands around 800 cm −1 and 870 cm −1 are associated with structural groups of the silicate glass [28] .…”

Section: Resultsmentioning

confidence: 95%

“…The particle size analysis ( Table 2 ) indicates that the addition of Fe 2 O 3 significantly hinders the particle growth (size decrease from 110 to 11 nm), which is in line with other reported experiments on different glass compositions [28] . It should be mentioned that the net negative surface charge of the particles ( Table 2 ) (about −30 mV) could be beneficial for enhancing the biological performance of the MBGs [29] .…”

Section: Discussionmentioning

confidence: 99%

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Iron (Fe)-doped mesoporous 45S5 bioactive glasses: Implications for cancer therapy

Kermani

Vojdani-Saghir

Mollazadeh

et al. 2022

Translational Oncology

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Iron (Fe)-doped mesoporous 45S5 bioactive glasses: Implications for cancer therapy

Kermani

Vojdani-Saghir

Mollazadeh

et al. 2022

Translational Oncology

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“…The FTIR spectra of the SBF-immersed MBGs after 7 days are shown in Figure 5 B. The marked bands (553–663) cm −1 , and (1000–1100) cm −1 are related to P-O bands [ 27 ]. The observed broad bands in the range of (1460–1560) cm −1 are connected with carbonated groups of the hydroxycarbonate apatite (HCA) layer [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Figure 9 displays the BET/BJH outcomes of the borate MBGs. Given the results and based on Brunauer–Deming–Deming–Teller theory (BDDT) classification, the glass samples belong to category IV and are closely attributed to the H4 class of mesoporous particles according to [ 27 ]. This class is related to irregular and broad-sized and/or ordered mesoporous particles.…”

Section: Resultsmentioning

confidence: 99%

Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing

et al. 2022

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In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (Tg). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol–gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns.

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“…HAp, with the chemical formula of Ca 10 (PO 4 ) 6 (OH) 2 , is considered to be the most stable calcium phosphate (CaP) biomaterial in the biological environment [ 19 , 20 , 21 , 22 ]. It should be noted that the biological response of HAp mainly relies on physicochemical properties, such as particle size, crystallinity degree, surface area, morphology, and surface charge [ 23 , 24 , 25 ]. For instance, a lower degree of crystallinity will result in a high dissolution rate.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

Kargozar

Mollazadeh

Kermani

et al. 2022

JFB

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Beyond their well-known applications in bone tissue engineering, hydroxyapatite nanoparticles (HAp NPs) have also been showing great promise for improved cancer therapy. The chemical structure of HAp NPs offers excellent possibilities for loading and delivering a broad range of anticancer drugs in a sustained, prolonged, and targeted manner and thus eliciting lower complications than conventional chemotherapeutic strategies. The incorporation of specific therapeutic elements into the basic composition of HAp NPs is another approach, alone or synergistically with drug release, to provide advanced anticancer effects such as the capability to inhibit the growth and metastasis of cancer cells through activating specific cell signaling pathways. HAp NPs can be easily converted to smart anticancer agents by applying different surface modification treatments to facilitate the targeting and killing of cancer cells without significant adverse effects on normal healthy cells. The applications in cancer diagnosis for magnetic and nuclear in vivo imaging are also promising as the detection of solid tumor cells is now achievable by utilizing superparamagnetic HAp NPs. The ongoing research emphasizes the use of HAp NPs in fabricating three-dimensional scaffolds for the treatment of cancerous tissues or organs, promoting the regeneration of healthy tissue after cancer detection and removal. This review provides a summary of HAp NP applications in cancer theranostics, highlighting the current limitations and the challenges ahead for this field to open new avenues for research.

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Improved osteogenesis and angiogenesis of theranostic ions doped calcium phosphates (CaPs) by a simple surface treatment process: A state-of-the-art study

Cited by 23 publications

References 47 publications

Iron (Fe)-doped mesoporous 45S5 bioactive glasses: Implications for cancer therapy

Iron (Fe)-doped mesoporous 45S5 bioactive glasses: Implications for cancer therapy

Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

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