Improved Production of Pharmacologically-active Sclerotiorin by &lt;i&gt;Penicillium sclerotiorum&lt;/i&gt;

Lucas, Esther Maria Ferreira; Machado, Yuri; Ferreira, Anderson A.; Dolabella, Luiza M.P.; Takahashi, Jacqueline Aparecida

doi:10.4314/tjpr.v9i4.58930

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…Contrary to this, in our case the effect of Mg on metabolite yield was significant. Similar inference was also made on the production of sclerotiorin by P. sclerotiorum [8]. Temperature and pH affect the regulation of molecules like ATP which in turn influence the regulation of metabolic pathways, coupled reactions and functional yields at the membrane and cell wall level [39].…”

Section: Discussionmentioning

confidence: 73%

“…Medium pH, temperature [35] and peptone [36] have been reported to be some of the most important experimental parameters influencing bioactive secondary metabolite production by Penicillium species. Dextrose and peptone were found to be important also in the production of sclerotiorin from P. sclerotiorum [8]. However Brian et al [30] reported that glucose was the best carbon source for wortmannin synthesis from P. wortmanni while glycerol was most favourable for mevastatin production by P. citrinum [37].…”

Section: Discussionmentioning

confidence: 99%

“…Fungi, particularly the filamentous ones, are highly potential reservoirs of products with excellent antagonistic activity against human pathogens [5]. A variety of secondary metabolites including antimicrobial substances is reported to have been produced by the fermentation of Penicillium species [6–8]. Their production depends upon the nutrition and cultivation conditions of the strains [9].…”

Section: Introductionmentioning

confidence: 99%

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Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation

Talukdar

Buragohain

et al. 2016

BMC Microbiol

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BackgroundMicroorganisms are a rich source of structurally diverse secondary metabolites that exert a major impact on the control of infectious diseases and other medical conditions. The biosynthesis of these metabolites can be improved by manipulating the nutritional or environmental factors. This work evaluates the effects of fermentation parameters on the production of a lactone compound effective against Candida albicans by Penicillium verruculosum MKH7 under submerged fermentation. Design–Expert version8.0 software was used for construction of the experimental design and statistical analysis of the experimental data.ResultsThe important factors influencing antibiotic production selected in accordance with the Plackett–Burman design were found to be initial pH, temperature, peptone, MgSO4.7H2O. Orthogonal central composite design and response surface methodology were adopted to further investigate the mutual interaction between the variables and identify the optimum values that catalyse maximum metabolite production. The determination coefficient (R2) of the fitted second order model was 0.9852. The validation experiments using optimized conditions of initial pH 7.4, temperature 27 °C, peptone 9.2 g/l and MgSO4.7H2O 0.39 g/l resulted in a significant increase (almost 7 fold from 30 to 205.5 mg/l) in the metabolite production which was in agreement with the prediction (211.24 mg/l). Stability of the compound was also assessed on the basis of its response to physical and chemical stresses.ConclusionsSo far as our knowledge goes, till date there are no reports available on the production of antibiotics by Penicillium verruculosum through media optimization using RSM. Optimization not only led to a 7 fold increase in metabolite yield but the same was achieved at much lesser time (8–10 days compared to the earlier 12–15 days). The enhanced yield of the antibiotic strongly suggests that the fungus P. verruculosum MKH7 can be efficiently used for antibiotic production on a large scale.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation

Talukdar

Buragohain

et al. 2016

BMC Microbiol

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“…Additionally, fungal endophytes residing in rare or endangered plants, rare ecological niches and extreme habitats have high economic value instead of the rich and diverse reserve of novel bioactive compounds. Some of the important pigments from endophytic fungi (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) are listed in Table 1 and soil fungi (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49) in Table 2. The chemical structures of prominent pigments from endophytic and soil fungi are depicted in Supplementary Tables 1 and 2 respectively.…”

Section: Biodiversity Of Fungal Endophytes In the Western Ghatsmentioning

confidence: 99%

Multifarious pigment producing fungi of Western Ghats and their potential

Sivakumar

Rao²,

Poornamath³

et al. 2022

Plant Sci. Today

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Concerns about the negative impacts of synthetic colorants on both consumers and the environment have sparked a surge of interest in natural colorants. This has boosted the global demand for natural colorants in the food, cosmetics and textile industries. Pigments and colorants derived from plants and microorganisms are currently the principal sources used by modern industry. When compared to the hazardous effects of synthetic dyes on human health, natural colors are quickly degradable and have no negative consequences. In fact, fungal pigments have multidimensional bioactivity spectra too. Western Ghats, a biodiversity hotspot has a lot of unique ecological niches known to harbor potential endophytic pigment-producing fungi having enumerable industrial and medical applications. Most of the fungi have coevolved with the plants in a geographical niche and hence the endophytic associations can be thought to bring about many mutually beneficial traits. The current review aims to highlight the potential of fungal pigments found in the Western ghats of India depicting various methods of isolation and screening, pigment extraction and uses. There is an urgent need for bioprospecting for the identification and characterization of extremophilic endophytic fungi to meet industry demands and attain sustainability and balance in nature, especially from geographic hotspots like the Western Ghats.

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“…The fungus usually produces distinctive bright orange pigments, some of which have been identified as carotenoids (4). It also makes several xylanases (5, 6), as well as sclerotiorin, a secondary metabolite that has been used in anti-acne creams and as an inhibitor of aldose reductase (7–10). Furthermore, it has biotechnological potential for producing calcium malate from glucose (11).…”

Section: Genome Announcementmentioning

confidence: 99%

Genome Sequencing and Analysis of the Filamentous Fungus Penicillium sclerotiorum 113, Isolated after Hurricane Sandy

et al. 2016

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Improved Production of Pharmacologically-active Sclerotiorin by <i>Penicillium sclerotiorum</i>

Cited by 12 publications

References 20 publications

Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation

Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation

Multifarious pigment producing fungi of Western Ghats and their potential

Genome Sequencing and Analysis of the Filamentous Fungus Penicillium sclerotiorum 113, Isolated after Hurricane Sandy

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