Improved Reactive Oxygen Species Generation by Chiral Co₃O₄ Supraparticles under Electromagnetic Fields

Abstract

One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease.T he aim of this treatment was to initiate the lysis of fibrin;h owever,t here are many side-effects associated with this form of treatment. Herein, we fabricated chiral Co 3 O 4 supraparticles (SPs) with ag-factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that d-SPs degraded blood clot within 8hours under MF.C ompared to l-SPs, d-SPs exhibited muchs tronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 %inthe 25 dofobservation. The results of mechanism study showed that under MF,t he level of reactive oxygen species (ROS) produced by d-SPs were 1.5 times higher than that of l-SPs,w hichm ight be attributed to the chiral-induced spin selectivity effects. Scheme 1. A) Illustration of chiral Co 3 O 4 SPs@PM preparation process and B) underlying mechanism of thrombolysis therapy by chiral Co 3 O 4 SPs@PM.

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