Improved thrombogenicity on oxygen etched Ti6Al4V surfaces

Riedel, Nicholas; Smith, Barbara; Williams, John D.; Popat, Ketul C.

doi:10.1016/j.msec.2012.03.008

Cited by 13 publications

(11 citation statements)

References 36 publications

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“…The scans were completed using an ESCA Systems X-ray Photoelectron Spectrometer 5800 with a monochromatic Al-K α -X-ray spot source at 1486.6 eV. [38]…”

Section: Methodsmentioning

confidence: 99%

Antibacterial activity on superhydrophobic titania nanotube arrays

Bartlet

Movafaghi

Dasi

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Bacterial infections are a serious issue for many implanted medical devices. Infections occur when bacteria colonize the surface of an implant and form a biofilm, a barrier which protects the bacterial colony from antibiotic treatments. Further, the anti-bacterial treatments must also be tailored to the specific bacteria that is causing the infection. The inherent protection of bacteria in the biofilm, differences in bacteria species (gram-positive vs. gram-negative), and the rise of antibiotic-resistant strains of bacteria makes device-acquired infections difficult to treat. Recent research has focused on reducing biofilm formation on medical devices by modifying implant surfaces. Proposed methods have included antibacterial surface coatings, release of antibacterial drugs from surfaces, and materials which promote the adhesion of non-pathogenic bacteria. However, no approach has proven successful in repelling both gram-positive and gram-negative bacteria. In this study, we have evaluated the ability of superhydrophobic surfaces to reduce bacteria adhesion regardless of whether the bacteria are gram-positive or gram-negative. Although superhydrophobic surfaces did not repel bacteria completely, they had minimal bacteria attached after 24 h and more importantly no biofilm formation was observed.

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“…The scans were completed using an ESCA Systems X-ray Photoelectron Spectrometer 5800 with a monochromatic Al-K α -X-ray spot source at 1486.6 eV. [38]…”

Section: Methodsmentioning

confidence: 99%

Antibacterial activity on superhydrophobic titania nanotube arrays

Bartlet

Movafaghi

Dasi

et al. 2018

Colloids and Surfaces B: Biointerfaces

Self Cite

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“…The manufacturers of the Heartmate‐II and other continuous flow VADs currently use a polished titanium alloy (Ti6Al4V) as the blood contacting surface due to its desirable mechanical properties, resistance to corrosion, and tolerable blood compatibility . However, in vitro studies have shown that this alloy exhibited elevated acute thrombogenicity compared to other coated surfaces (e.g., polyethylene glycol and diamond‐like coatings) or related alloys (Ti6Al7Nb) . This study was therefore conducted to perform a systematic side‐by‐side comparison of six candidate biomaterials currently being considered for application in continuous‐flow blood pumps.…”

Section: Introductionmentioning

confidence: 99%

“…11 However, in vitro studies have shown that this alloy exhibited elevated acute thrombogenicity compared to other coated surfaces (e.g., polyethylene glycol and diamond-like coatings) or related alloys (Ti6Al7Nb). 2,5,12,13 This study was therefore conducted to perform a systematic side-by-side comparison of six candidate biomaterials currently being considered for application in continuous-flow blood pumps. However, since these materials are opaque, traditional methods for real time visualization of platelet deposition, such as fluorescent microscopy utilizing whole blood, are not readily applicable.…”

Section: Introductionmentioning

confidence: 99%

Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces

Jamiolkowski

Woolley

Kameneva

et al. 2014

J. Biomed. Mater. Res.

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Although the thrombogenic nature of the surfaces of cardiovascular devices is an important aspect of blood biocompatibility, few studies have examined platelet deposition onto opaque materials used for these devices in real time. This is particularly true for the metallic surfaces used in current ventricular assist devices (VADs). Using hemoglobin depleted red blood cells (RBC ghosts) and long working distance optics to visualize platelet deposition, we sought to perform such an evaluation. Fluorescently labeled platelets mixed with human RBC ghosts were perfused across 6 opaque materials (a titanium alloy (Ti6Al4V), silicon carbide (SiC), alumina (Al2O3), 2-methacryloyloxyethyl phosphorylcholine polymer coated Ti6Al4V (MPC-Ti6Al4V), yttria partially stabilized zirconia (YZTP), and zirconia toughened alumina (ZTA)) for 5 min at wall shear rates of 400 and 1000 sec−1. Ti6Al4V had significantly increased platelet deposition relative to MPC-Ti6Al4V, Al2O3, YZTP, and ZTA at both wall shear rates (P <0.01). For all test surfaces, increasing the wall shear rate produced a trend of decreased platelet adhesion. The described system can be a utilized as a tool for comparative analysis of candidate blood-contacting materials with acute blood contact.

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“…In general, the biocompatibility is modulated by the biomaterial surface (interfacial) or structural properties. Although biocompatible, titanium exhibits a thrombogenicity that can generate the formation of a blood clot [18]. The modification of its surface can modulate not only its integration into the body but also bacterial adhesion [19], [20], or even make it bioactive.…”

Section: Discussionmentioning

confidence: 99%

PEM Anchorage on Titanium Using Catechol Grafting

et al. 2012

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BackgroundThis study deals with the anchorage of polyelectrolyte films onto titanium surfaces via a cathecol-based linker for biomedical applications.MethodologyThe following study uses a molecule functionalized with a catechol and a carboxylic acid: 3-(3,4-dihydroxyphenyl)propanoic acid. This molecule is anchored to the TiO2 substrate via the catechol while the carboxylic acid reacts with polymers bearing amine groups. By providing a film anchorage of chemisorption type, it makes possible to deposit polyelectrolytes on the surface of titanium.Principal FindingsInfrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), contact angle and atomic force microscopy (AFM) measurements show that the different steps of grafting have been successfully performed.ConclusionsThis method based on catechol anchorage of polyelectrolytes open a window towards large possibilities of clinical applications.

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Improved thrombogenicity on oxygen etched Ti6Al4V surfaces

Cited by 13 publications

References 36 publications

Antibacterial activity on superhydrophobic titania nanotube arrays

Antibacterial activity on superhydrophobic titania nanotube arrays

Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces

PEM Anchorage on Titanium Using Catechol Grafting

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