Improved understanding of the pathophysiology of atrial fibrillation through the lens of discrete pathological pathways

Balouch, Muhammad; Kolek, Matthew J.; Darbar, Dawood

doi:10.5339/gcsp.2014.5

Cited by 14 publications

(14 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Valvular abnormalities, hypertension, and diabetes have been associated to AF. Actually, genetics and molecular pathways are deeply involved in the development of the disease [101]. …”

Section: Methodsmentioning

confidence: 99%

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Pérez-Hernández

Aptilon-Duque

Nostroza-Hernández

et al. 2016

Korean J Intern Med

View full text Add to dashboard Cite

Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.

show abstract

“…Valvular abnormalities, hypertension, and diabetes have been associated to AF. Actually, genetics and molecular pathways are deeply involved in the development of the disease [101]. …”

Section: Methodsmentioning

confidence: 99%

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Pérez-Hernández

Aptilon-Duque

Nostroza-Hernández

et al. 2016

Korean J Intern Med

View full text Add to dashboard Cite

show abstract

“…Polidoro (24)(25)(26). Cross-sectional studies have shown that patients with prevalent AF have higher levels of CRP than age-matched controls (27,28). Longitudinal studies have shown that individuals with high levels of CRP are at risk for developing de novo incident AF (29).…”

Section: Implications Of Frailty For Af Carementioning

confidence: 97%

Implications of Frailty in Elderly Patients With Electrophysiological Conditions

Bibas¹,

Levi²,

Touchette³

et al. 2016

JACC: Clinical Electrophysiology

View full text Add to dashboard Cite

A growing number of complex older adults are referred for electrophysiological conditions and age alone is insufficient to guide management decisions such as implantable cardioverter-defibrillator (ICD) implantation or atrial fibrillation anticoagulation. The concept of frailty has emerged as a geriatric vital sign to gain insight into physiological reserve and prognostic risk beyond chronological age and comorbidities. To date, a number of published studies have evaluated frailty in patients with electrophysiological conditions. These studies collectively demonstrate that frail patients have an increased prevalence of atrial fibrillation, lower use of oral anticoagulation, higher risk of bleeding complications from oral anticoagulation, and higher risk of stroke and mortality. A paucity of studies have explored frailty in the setting of device implantation, with a signal suggesting that frail heart failure patients may have a lower likelihood of being considered for ICD and cardiac resynchronization therapy devices, and a higher risk of fatal and nonfatal events after ICD and cardiac resynchronization therapy implantation. Whether frailty modulates the risks and benefits of these devices is a critical knowledge gap for which further study is clearly warranted. (J Am Coll Cardiol EP 2016;2:288-94)

show abstract

“…[12][13][14] Despite the importance of both genetic predisposition and atrial fibrosis in the pathophysiology of AF, little is known about how these two factors relate or interact with one another. 15,16 For example, it is unknown if genetic variants promote substrate changes, such as atrial fibrosis. Furthermore, it is unknown whether atrial fibrosis is associated with higher risk of recurrent AF in patients with and without genetic predisposition to AF.…”

mentioning

confidence: 99%

Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation

Choi

Baek

Roh

et al. 2019

Cardiovasc electrophysiol

View full text Add to dashboard Cite

Introduction Little is known about how genetic predisposition and fibrosis relate in atrial fibrillation (AF). Hence, we sought to determine whether the genetic variants and biomarkers for fibrosis enhance prediction of outcomes after catheter ablation. Methods and Results Consecutive patients who underwent catheter ablation of AF (paroxysmal, 158; nonparoxysmal, 137) or supraventricular tachycardia without AF (n = 70) were studied retrospectively. Plasma levels of transforming growth factor β1 (TGF‐β1), tissue inhibitor of metalloproteinase 1 (TIMP‐1), and 4q25 single‐nucleotide polymorphisms (SNPs) (rs10033464 and rs220073) were measured. Mean plasma levels of both TGF‐β1 and TIMP‐1 were higher in patients with AF than in the control (all P < .001). Plasma levels of TIMP‐1 were higher in patients with recurrence compared with those without recurrence (P = .039). Patients with variant alleles of rs10033464 showed increased recurrence after catheter ablation in patients with paroxysmal AF including after adjustment (P = .027). Patients with TIMP‐1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF. Inclusion of biomarkers and genotype improved discrimination of AF recurrence in patients with paroxysmal AF (C‐statistic .499 vs .600). Conclusions The combination of plasma TIMP‐1 concentrations less than 107 ng/mL and the absence of a variant allele at rs10033464 was associated with lower recurrence rates in patients with paroxysmal AF. This study suggests that 4q25 SNPs and biomarkers for fibrosis may provide additive value in risk stratification for AF recurrence after catheter ablation.

show abstract

Improved understanding of the pathophysiology of atrial fibrillation through the lens of discrete pathological pathways

Cited by 14 publications

References 124 publications

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Implications of Frailty in Elderly Patients With Electrophysiological Conditions

Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation

Contact Info

Product

Resources

About