SummaryVisit-to-visit variability (VVV) in blood pressure (BP) has been shown to be a predictor of cardiovascular events. It is unknown whether CR can improve VVV in BP as well as reducing BP. We enrolled 84 patients who had cardiovascular disease (CVD) and participated in a 3-month CR program. We measured systolic and diastolic BP (SBP and DBP), pulse pressure (PP), and heart rate (HR) before exercise training at each visit and determined VVV in BP or HR expressed as the standard deviation of the average BP or HR. Patients who had uncontrolled BP at baseline and who did not change their antihypertensive drugs throughout the study period showed a significant reduction of both SBP and DBP with a decrease in PP after 3 months. Patients who did not change their antihypertensive drugs were divided into larger (L-) and smaller (S-) VVV in the SBP groups and L-and S-VVV in the DBP groups according to the average value of VVV in SBP or DBP. In the L-VVV in the SBP and DBP groups, VVV in SBP and DBP in the 1st month was significantly decreased after the 3rd month in both groups. HR at baseline was significantly decreased after 3 months. In addition, CR induced a significant increase in the level of high-density lipoprotein cholesterol (HDL-C) in blood. In conclusion, CR improved VVV in BP in patients with L-VVV in BP and evoked a significant reduction in HR and an increase in HDL-C. These effects due to the CR program may be cardioprotective. (Int Heart J 2016; 57: 607-614) Key words: Cardioprotection, Heart rate, High-density lipoprotein cholesterol C ardiac rehabilitation (CR) is designed to help patients recovering from a heart attack, other various cardiovascular diseases, (CVD) or cardiac surgery. CR is a comprehensive therapy and can improve physical activity and psychological function, quality of life, and the prognosis in patients with CVD.
1-7)The prognostic value of blood pressure (BP) is based mainly on measurements obtained in a clinical setting. 7) High BP is a major risk factor for the onset and progression of CVD,8) and exercise training has been shown to reduce BP in patients with hypertension (HTN).9,10) A recent report indicated that visit-to-visit variability (VVV) in BP is reproducible and not a random phenomenon.11) The Anglo-Scandinavian Cardiac Outcomes Trial Blood Pressure Lowering Arm reported that VVV in systolic BP (SBP) and maximum SBP were significantly associated with future risks of stroke and other CVD events independent of mean BP and other cardiovascular risk factors.12) Moreover, others have also indicated that VVV in BP is a predictor of the development of atherosclerotic diseases including stroke and myocardial infarction, and cardiovascular and all-cause mortality.12-15) Nonetheless, there is no recommendation on how to manage patients with CVD regarding the optimal control of VVV in BP.