Improvement in endothelium-dependent brachial artery flow-mediated vasodilation with low-density lipoprotein cholesterol levels &lt;100 mg/dl

Shechter, Michael; Sharir, Michael; Labrador, Maura J. Paul; Forrester, James S.; Merz, C. Noel Bairey

doi:10.1016/s0002-9149(00)01214-5

Cited by 24 publications

(15 citation statements)

References 19 publications

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“…For subjects with T2DM mediated vasodilation flow ranged from 0.75 to 12%, confirming our findings, showing that the subjects in our research were initially with endothelial dysfunction, being restored after six weeks of exercise 23 . Our study is in agreement with the literature 24 , mainly standardizing occlusion location (upper arm) and duration of occlusion (five minutes), annulling possible differences due to technical aspects.…”

Section: Discussionsupporting

confidence: 92%

Effect of High-Intensity Exercise on Endothelial Function in Patients With T2dm

Silva

Vasconcelos-Filho

Serafim³

et al. 2016

Rev Bras Med Esporte

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Introduction: Diabetes mellitus is the most common metabolic disease worldwide. Endothelial dysfunction characteristic of these patients is one of the major risk factors for atherosclerosis. Early diagnosis of endothelial dysfunction is essential for the treatment especially of non-invasive manner, such as flow mediated dilation. Physical exercise is capable of generating beneficial adaptations may improve endothelial function. Objective: Identify the effect of physical exercise, using the clinical technique of ultrasound in the assessment of the endothelial function of patients with metabolic syndrome or type 2 diabetes mellitus. Methods: Thirty-one patients with type 2 diabetes mellitus or metabolic syndrome were studied, with a mean age (± SD) of 58±6 years, randomized into three groups. The training was performed for 50 minutes, four times a week. Before and after six weeks of training, subjects performed the endurance test and a study of the endothelial function of the brachial artery by high-resolution ultrasound. Results: After hyperemia, the percentage of arterial diameter was significantly higher for the high-intensity group (HI before = 2.52±2.85mm and after = 31.81±12.21mm; LI before = 3.23±3.52mm and after = 20.61±7.76mm; controls before = 3.56±2.33mm and after = 2.43±2.14mm; p<0.05). Conclusions: The high-intensity aerobic training improved the vasodilatation response-dependent endothelium, recorded by ultrasound, in patients with metabolic syndrome and type 2 diabetes.

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Section: Discussionsupporting

confidence: 92%

Effect of High-Intensity Exercise on Endothelial Function in Patients With T2dm

Silva

Vasconcelos-Filho

Serafim³

et al. 2016

Rev Bras Med Esporte

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“…1 A common feature of proatherosclerotic states, including hypercholesterolemia, hypertension, and diabetes mellitus, is the ROSmediated loss of homeostatic functions of the vascular endothelium, which normally acts to promote vasodilatation and to inhibit inflammation and thrombosis. 2 Endothelial dysfunction has been associated with risk factors for the development of atherosclerosis 3,4 and identified as a predictor of adverse cardiovascular events. 5 …”

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confidence: 99%

Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

Loukogeorgakis

Sofat

et al. 2010

Circulation

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Background-Reactive oxygen species have been implicated in the pathogenesis of ischemia/reperfusion (IR) injury. Recent studies suggest that NADPH oxidase may be a source of ROS during IR. Using an in vivo model of endothelial IR injury in the arm, we compared the response to IR in healthy volunteers with that in patients with chronic granulomatous disease. These patients have a molecular lesion in a subunit of NADPH oxidase that renders the enzyme inactive. Methods and Results-Flow-mediated dilatation was used to assess endothelial function in patients with X-linked (NOX2) or autosomal (p47) chronic granulomatous disease. IR injury was induced by 20 minutes of upper limb ischemia followed by reperfusion. Flow-mediated dilatation was determined before IR and after 20 minutes of reperfusion. The response to IR in chronic granulomatous disease patients was compared with that in age-and sex-matched healthy control subjects. Flow-mediated dilatation was expressed as mean and compared statistically with mixed linear models. IR caused a significant reduction in flow-mediated dilatation in control subjects (Ϫ5.1%; 95% confidence interval, 6.3 to 3.%; PϽ0.001; nϭ11). IR had no effect on endothelial function in NOX2-chronic granulomatous disease patients (Ϫ0.9; 95% confidence interval, Ϫ2.1 to 0.3; Pϭ0.12; nϭ11). Similarly, IR-induced reduction in flow-mediated dilatation was not observed in p47-chronic granulomatous disease patients (Ϫ1.5%; 95% confidence interval, Ϫ3.1 to 0.2; Pϭ0.08; nϭ6) in contrast to healthy control subjects (Ϫ6.5%; 95% confidence interval, Ϫ8.2 to Ϫ4.9%; PϽ0.001; nϭ6). Conclusions-These data indicate, for the first time in humans in vivo, that reactive oxygen species produced by NADPH oxidase are determinants of endothelial function after IR injury in humans. These findings have implications for the design of strategies to limit clinical IR injury. (Circulation. 2010;121:2310-2316.)

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“…All measurements were made at end diastole to avoid possible errors resulting from variable arterial compliance [26]. The internal diameter was calculated by a single cardiologist (MS) blinded to both patient and control status, with PC Prosound software (USC, California) using a Horita data translation image processing board (DT2862-60 Hz) [23]. The diameter change caused by endothelium-dependent flow-mediated vasodilatation (%FMD) and endothelium-independent percent change from baseline in nitroglycerin-mediated vasodilation (%NTG), were expressed as the percent change relative to that at the initial resting scan.…”

Section: Discussionmentioning

confidence: 99%

“…Endothelial function in the form of endotheliumdependent brachial artery FMD was measured at 06:30 am as previously described [12,23,24]. Briefly, FMD was assessed in the subject's right arm in the recumbent position in a temperature-controlled room (22°C) after a 10 min equilibration period by a single ultrasonographer.…”

Section: Vascular Function Protocolmentioning

confidence: 99%