Background-Magnesium blocks many of the physiological actions of calcium. Nevertheless, the impact of magnesium supplementation on endothelial function and exercise tolerance in stable coronary artery disease (CAD) patients has not been assessed. Methods and Results-In a randomized, double-blind, placebo-controlled trial, 50 stable CAD patients (41 men and 9 women, meanϮSD age 67Ϯ11 years, age range 42 to 82 years) were randomized to receive either magnesium (nϭ25) (30 mmol/d Magnosolv-Granulat; Asta Medica Company, Inc) or placebo (nϭ25) for 6 months. Before and after 6 months, endotheliumdependent brachial artery flow-mediated vasodilation (FMD) and endothelium-independent NTG-mediated vasodilation were assessed with high-resolution (10-MHz) ultrasound. Exercise stress testing was performed with use of the Bruce protocol. Intracellular magnesium concentrations ([Mg

No abstract

No abstract