Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

Shechter, Michael; Sharir, Michael; Labrador, Maura J. Paul; Forrester, James S.; Silver, Burton B.; Merz, C. Noel Bairey

doi:10.1161/01.cir.102.19.2353

Cited by 244 publications

(194 citation statements)

References 39 publications

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“…Magnesium-induced favorable vascular effects have been demonstrated in many organ systems and previously discussed [12,13,26]. Therefore, these could explain how magnesium may have potential therapeutic effect in some diseases associated with perfusion abnormality via local microcirculatory disturbances and decreased blood flow such as NTG.…”

Section: Putative Therapeutic Effect In Glaucomamentioning

confidence: 88%

“…Endothelium-dependent vasodilation mediated by NO is induced with magnesium by modifying formation and release of NO [9][10][11]. Indeed, magnesium therapy may improve endothelial function in patients with diabetes and coronary artery diseases [12,13]. Magnesium tends to increase blood flow, and decreases vascular resistance in various vascular beds [6,9,12,14].…”

Section: Introductionmentioning

confidence: 99%

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Magnesium: Effect on ocular health as a calcium channel antagonist

Korkmaz

Ekici²,

Tufan³

et al. 2013

J Clin Exp Invest

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ÖZETMagnezyum hücre zar fonksiyonlarını, düz kas kontraksiyonlarını ve enzimatik reaksiyonları etkileyerek pek çok metabolik sürece katılan fizyolojik bir kalsiyum kanal blokörüdür. Magnezyumun Endothelin-1 (ET-1) ve Nitrik Oksit (NO) yolakları vasıtasıyla endotel fonksiyonları-nı modifiye ederek dokulara kan akımında artışa neden olduğu gösterilmiştir. Magnezyum aynı zamanda N-metil-D-aspartat (NMDA) reseptör ilişkili kalsiyum içe akımı-nı bloke ederek ve glutamat serbestleşmesini önleyerek nöroprotektif rol oynamakta ve hücreleri oksidatif stres ve apoptoza karşı korumaktadır. Hem kan akımında artışa neden olması hem de nöroprotektif etkileri magnezyumu glokom çalışmaları için iyi bir hedef molekül yapmaktadır. Magnezyumun retinada oksidatif stresi ve apoptozu azalttığı ve ganglion koruyucu etkileri olduğu gösterilmiştir. Bir takım çalışmalarda aynı zamanda magnezyumun diabetik hastalarda insulin resistansını azalttığı, glisemik kontrolü kolaylaştırdığı ve retinopatiyi önlediği gösterilmiştir. Magnezyumun lensteki iyon dengesinin sağlanmasında kritik önemi belirlenmiştir. Magnezyum eksikliğinin lentiküler oksidatif stresi arttırdığı ve iyon dengesini bozarak katarakt oluşumuna neden olduğu gösterilmiştir.Anahtar kelimeler: Magnezyum, kalsiyum kanal blokajı, glokom, nöroproteksiyon, diabetik retinopati, katarakt ABSTRACTMagnesium is the physiologic calcium channel blocker, involving in many different metabolic processes by maintaining cell membrane function, modulating smooth muscle contraction and influencing enzymatic activities. Magnesium has been shown to increase blood flow to tissues by modifying endothelial function via endothelin-1 (ET-1) and nitric Oxide (NO) pathways. Magnesium also exhibits neuroprotective role by blocking N-methyl-D-aspartate (NMDA) receptor related calcium influx and by inhibiting the release of glutamate, hence protects the cell against oxidative stress and apoptosis. Both increase in blood flow and its neuroprotective effect make magnesium a good candidate for glaucoma studies. Magnesium has been shown to decrease oxidative stress and apoptosis in retinal tissue and to have retinal ganglion cell sparing effect. A series of studies has been conducted about magnesium could decrease insulin resistance in diabetic patients, ease glycemia control and prevent diabetic retinopathy. Magnesium is found to be critically important in maintaining normal ionic homeostasis of lens. Magnesium deficiency has been shown to cause increased lenticular oxidative stress and ionic imbalance in the lens so trigger cataractogenesis. J Clin Exp Invest 2013; 4 (2): 244-251

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Section: Putative Therapeutic Effect In Glaucomamentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Magnesium: Effect on ocular health as a calcium channel antagonist

Korkmaz

Ekici²,

Tufan³

et al. 2013

J Clin Exp Invest

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“…Mg kalsiyum antagonisti olduğu için eksikliğinde kalsiyum yükü artar. Bu durum endotel fonksiyonlarında bozulmaya neden olur (17). Bu sebeple Mg miyokard enfarktüsü gibi kardiyak olaylarda koruyucu etkiye sahiptir (18 …”

Section: Kalp üZerine Olan Etkilerunclassified

The Unknown Miracle of the Forgotten Element: “Magnesium and Immunity”

Demirtürk¹,

Esen²

2017

tybdd

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47ÖZ Bu derleme magnezyumun pek çok kullanım alanına ek olarak kritik hastada enflamasyon sürecine etkisi, immün sisteme olan katkısını göstermeyi amaçlamıştır. Magnezyum insan vücudunda ekstrasellüler alanda dördüncü sırada, intrasellüler olarak da ikinci olarak en sık bulunan katyonu olup; nükleik asit ve protein sentezi gibi birçok temel reaksiyonda enzim kofaktörü olarak rol alması, hücre membran stabilizasyonunu sağlaması gibi görevleri göz önüne alındığında son derece önemli bir elementtir. Diğer pek çok elektrolite kıyasla en önemli özelliği immün sisteme ve canlı immünitesine olan etkisidir. Yoğun bakımda yatan immünosüpresif ya da immünokompetan olan her grup hastada magnezyum eksikliği desteklenmeli ve pek çok yararına ek olarak magnezyumun immmün sisteme katkısı akılda tutulmalıdır. Anahtar Kelimeler: Magnezyum, immünite, inflamasyon ABSTRACT This review aims to demonstrate the relation between magnesium and the immune system and their effect on inflammatory process in the critical patient, in addition to many other clinical uses of magnesium. Magnesium is the fourth most commonly found cation in the extracellular space in the human body and the second most common cation in the cell. Magnesium is an extremely important element when considering its role as an enzyme cofactor in many basic reactions, such as nucleic acid, protein synthesis and cell membrane stabilization. The most important features compared to other electrolytes is its effect on the immune system and living immunity. For each group of immunosuppressive or immunocompenent patients in intensive care unit, magnesium deficiency should be supported and in addition to other clinical benefits, the contribution of magnesium to the immune system should be kept in mind.

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“…showed that cocoa flavan-3-ols modulated the secretion and transcription of IL-1β and TNF-α in peripheral blood mononuclear cells (PBMCs) collected from healthy volunteers [73,74]. In an animal study, Morrison et al showed that pure epicatechin supplementation prevented diet-induced activation of aortic NF-κB in ApoE*3-Leiden mice fed an atherogenic diet [75].…”

Section: Molecular Mechanisms Of Epicatechin and Quercetinmentioning

confidence: 99%

“…Effects of magnesium on vascular function are unclear with two RCTs reporting that magnesium improved FMD [72,73], and another reporting no change [74]. Theobromine could contribute to the cardioprotective effects of cocoa by reducing arterial stiffness and central blood pressure [9].…”

Section: Of Cocoamentioning

confidence: 99%

Dietary epicatechnin and quercetin in cardiovascular health and disease

Dower¹

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Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

Cited by 244 publications

References 39 publications

Magnesium: Effect on ocular health as a calcium channel antagonist

Magnesium: Effect on ocular health as a calcium channel antagonist

The Unknown Miracle of the Forgotten Element: “Magnesium and Immunity”

Dietary epicatechnin and quercetin in cardiovascular health and disease

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