Improvement in hemocompatibility of chitosan/soy protein composite membranes by heparinization

Preliminary investigation on hemocompatibility of poly(vinylidene fluoride) membrane grafted with acryloylmorpholine via ATRP

“…Red blood cells hemolyse when they are in contact with an implant material. The release of adenosine diphosphate within the broken red blood cells can strengthen the assembly of blood platelets, which accelerates the formation of clotting and thrombus . The hemolysis test results of the pristine PVDF and PVDF ‐g‐ PACMO membranes are also shown in Figure .…”

“…The release of adenosine diphosphate within the broken red blood cells can strengthen the assembly of blood platelets, which accelerates the formation of clotting and thrombus. 39 The hemolysis test results of the pristine PVDF and PVDF-g-PACMO membranes are also shown in Figure 10. The hemolysis rate (HR) of the PVDF membrane is about 4.8%, which is close to the value reported in the literature.…”

Protein-based materials: from sources to innovative sustainable materials for biomedical applications

“…168 Hitherto, soy proteins have been exploited for the elaboration of blends and composite materials with different plasticizers, surfactants, biodegradable polymers, lipids and essential oils, and llers. 9,168 For example, defatted soy our (DSF) has been used to prepare biocomposites of kenaf bre, 167 elastomer composites, 171 and composites with polypropylene; 172 soy protein concentrate (SPC) has been utilized to fabricate blends and composites with gelling agents, 146 Eastar™ Bio copolyester, 173 poly(butylene adipate-co-terephthalate), 174 PLA, 175 maleated PLA, 163 stearic acid/palmitic acid, 176 halloysite nanotubes, 166 etc., whereas soy protein isolate (SPI) has been extensively studied for the preparation of blends and composites with cellulose, 177 wheat-bran cellulose, 149 chitosan, 178,179 woven ax fabric, 164 corn our, 159 PLA, 160,180 polyurethane, 161,181 montmorillonite nanoclay, 158 TiO 2 , 182 silver NPs, 183 among many others. 168 Representative examples of the ongoing research in the eld of SP blends and composites include the work of Zhang et al 181 on blend lms of a poly(butylene adipate) based waterborne polyurethane (WPU) with SPI.…”

“…SP has also been used together with natural biopolymers as pointed out e.g. by the study of Wang et al 179 on a series of heparinized chitosan/SPI composite membranes. The resulting membranes prepared via blending of chitosan, SPI and heparin displayed a higher hemocompatibility, which was assumed to be due to heparinization, and are expected to widen the application of chitosan and SPI based biomaterials that might involve contact with blood.…”

Films based on soy protein-agar blends for wound dressing: Effect of different biopolymer proportions on the drug release rate and the physical and antibacterial properties of the films

“…11 To overcome this limitation, SP has been blended with other proteins and polysaccharides. 12–17 Some blends have demonstrated to have potential in wound healing. Chitosan/SP membranes produced by solvent casting have been shown to promote low in vitro activation of human polymorphonuclear neutrophils isolated from circulating blood, decreasing the healing time period of partial-thickness skin wounds.…”